ID   RN224_MOUSE             Reviewed;         156 AA.
AC   Q3UIW8;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=RING finger protein 224;
GN   Name=Rnf224; Synonyms=Gm757;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Amnion;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AK146725; BAE27388.1; -; mRNA.
DR   EMBL; BC147425; AAI47426.1; -; mRNA.
DR   EMBL; BC147426; AAI47427.1; -; mRNA.
DR   RefSeq; NP_001028582.1; NM_001033410.2.
DR   AlphaFoldDB; Q3UIW8; -.
DR   SMR; Q3UIW8; -.
DR   iPTMnet; Q3UIW8; -.
DR   PhosphoSitePlus; Q3UIW8; -.
DR   PaxDb; Q3UIW8; -.
DR   PRIDE; Q3UIW8; -.
DR   Antibodypedia; 69700; 51 antibodies from 11 providers.
DR   Ensembl; ENSMUST00000091318; ENSMUSP00000145470; ENSMUSG00000089953.
DR   Ensembl; ENSMUST00000205192; ENSMUSP00000145127; ENSMUSG00000089953.
DR   GeneID; 329360; -.
DR   KEGG; mmu:329360; -.
DR   UCSC; uc008iqu.1; mouse.
DR   CTD; 643596; -.
DR   MGI; MGI:2685603; Rnf224.
DR   VEuPathDB; HostDB:ENSMUSG00000089953; -.
DR   eggNOG; ENOG502S2Y1; Eukaryota.
DR   GeneTree; ENSGT00510000050587; -.
DR   InParanoid; Q3UIW8; -.
DR   OMA; ANEQRWI; -.
DR   OrthoDB; 1337075at2759; -.
DR   PhylomeDB; Q3UIW8; -.
DR   TreeFam; TF331690; -.
DR   BioGRID-ORCS; 329360; 1 hit in 44 CRISPR screens.
DR   PRO; PR:Q3UIW8; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q3UIW8; protein.
DR   Bgee; ENSMUSG00000089953; Expressed in yolk sac and 10 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR027370; Znf-RING_LisH.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF13445; zf-RING_UBOX; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..156
FT                   /note="RING finger protein 224"
FT                   /id="PRO_0000412183"
FT   ZN_FING         23..70
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   156 AA;  17382 MW;  49D0144248ADDB40 CRC64;
     MLQPEGLYAL EEGTALTASR NDCIICYSAY DLSVHLPRRL YCGHTFCQAC MQRLDMPAHE
     QHWIPCPQCR QSTPVPRGGV TMLDLDLAAF LAVKAEREPS KIEPRSSVPL KISTTITQQP
     AGLYPTLGPQ PHFPQPGCCC WGWGRLCWYP PGNPEV