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RN225_HUMAN
ID   RN225_HUMAN             Reviewed;         329 AA.
AC   M0QZC1;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   29-OCT-2014, sequence version 2.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=RING finger protein 225 {ECO:0000312|HGNC:HGNC:51249};
GN   Name=RNF225 {ECO:0000312|HGNC:HGNC:51249};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
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DR   EMBL; AC012313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471135; EAW72584.1; -; Genomic_DNA.
DR   CCDS; CCDS74477.1; -.
DR   RefSeq; NP_001182064.1; NM_001195135.1.
DR   RefSeq; XP_006723391.1; XM_006723328.3.
DR   AlphaFoldDB; M0QZC1; -.
DR   STRING; 9606.ENSP00000470441; -.
DR   iPTMnet; M0QZC1; -.
DR   PhosphoSitePlus; M0QZC1; -.
DR   BioMuta; RNF225; -.
DR   MassIVE; M0QZC1; -.
DR   PaxDb; M0QZC1; -.
DR   PeptideAtlas; M0QZC1; -.
DR   PRIDE; M0QZC1; -.
DR   DNASU; 646862; -.
DR   Ensembl; ENST00000601382.3; ENSP00000470441.2; ENSG00000269855.3.
DR   GeneID; 646862; -.
DR   KEGG; hsa:646862; -.
DR   MANE-Select; ENST00000601382.3; ENSP00000470441.2; NM_001195135.2; NP_001182064.1.
DR   UCSC; uc021vcz.1; human.
DR   CTD; 646862; -.
DR   GeneCards; RNF225; -.
DR   HGNC; HGNC:51249; RNF225.
DR   HPA; ENSG00000269855; Tissue enhanced (esophagus, skin, vagina).
DR   neXtProt; NX_M0QZC1; -.
DR   OpenTargets; ENSG00000269855; -.
DR   VEuPathDB; HostDB:ENSG00000269855; -.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00940000163974; -.
DR   HOGENOM; CLU_1013832_0_0_1; -.
DR   InParanoid; M0QZC1; -.
DR   OMA; WVFNAAV; -.
DR   OrthoDB; 1337075at2759; -.
DR   BioGRID-ORCS; 646862; 11 hits in 182 CRISPR screens.
DR   GenomeRNAi; 646862; -.
DR   Pharos; M0QZC1; Tdark.
DR   PRO; PR:M0QZC1; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; M0QZC1; protein.
DR   Bgee; ENSG00000269855; Expressed in esophagus mucosa and 27 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Membrane; Metal-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..329
FT                   /note="RING finger protein 225"
FT                   /id="PRO_0000431309"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         64..112
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          122..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..181
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        248..264
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        290..304
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  34789 MW;  32B366C4EF36284D CRC64;
     MPCPRPFWLR HSRAPQGSGP SSPGSLSAPR SPSRGEDQEE EEEEEGDGSP GSGPILPPAS
     PVECLICVSS FDGVFKLPKR LDCGHVFCLE CLARLSLATA GGGNAVACPV CRAPTRLAPR
     RGLPALPTQS GLLPRDARAP PSRQGSVRFD RRRGLLYLRP PPPPPGPRKA RAPPPPPPLR
     LGRPLSRRLS LASPAWVFNA AVALAVLVAA GLVVSGVYIF FLIPHATSSG PPRPQLVALA
     PAPGFSWFPP RPPPGSPWAP AWTPRPTGPD LDTALPGTAE DALEPEAGPE DPAEAERTLD
     RRSDGTWGTE AGPGWAPWPR GARRLWGSQ
 
 
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