ID   RN26_HAEIN              Reviewed;         272 AA.
AC   P44012;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Probable ribonuclease HI_0526;
DE   Flags: Precursor;
GN   OrderedLocusNames=HI_0526;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SIMILARITY: Belongs to the RNase T2 family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22192.1; -; Genomic_DNA.
DR   PIR; C64009; C64009.
DR   RefSeq; NP_438684.1; NC_000907.1.
DR   RefSeq; WP_005694129.1; NC_000907.1.
DR   AlphaFoldDB; P44012; -.
DR   SMR; P44012; -.
DR   STRING; 71421.HI_0526; -.
DR   PRIDE; P44012; -.
DR   EnsemblBacteria; AAC22192; AAC22192; HI_0526.
DR   KEGG; hin:HI_0526; -.
DR   PATRIC; fig|71421.8.peg.545; -.
DR   eggNOG; COG3719; Bacteria.
DR   HOGENOM; CLU_069375_0_0_6; -.
DR   OMA; GLWPQNA; -.
DR   PhylomeDB; P44012; -.
DR   BioCyc; HINF71421:G1GJ1-539-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0033897; F:ribonuclease T2 activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006401; P:RNA catabolic process; IBA:GO_Central.
DR   Gene3D; 3.90.730.10; -; 1.
DR   InterPro; IPR001568; RNase_T2-like.
DR   InterPro; IPR036430; RNase_T2-like_sf.
DR   InterPro; IPR018188; RNase_T2_His_AS_1.
DR   InterPro; IPR033130; RNase_T2_His_AS_2.
DR   PANTHER; PTHR11240; PTHR11240; 1.
DR   Pfam; PF00445; Ribonuclease_T2; 1.
DR   SUPFAM; SSF55895; SSF55895; 1.
DR   PROSITE; PS00530; RNASE_T2_1; 1.
DR   PROSITE; PS00531; RNASE_T2_2; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..272
FT                   /note="Probable ribonuclease HI_0526"
FT                   /id="PRO_0000030963"
FT   ACT_SITE        148
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        195
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        199
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   272 AA;  31482 MW;  9D580FF9C2CEB392 CRC64;
     MKKLTSILSL IVLVILAIWQ YFTDTTKTKH QSSSPVIEQT KQTKVSEPKF EPKFEPKFEP
     KFEPQFETKR TDIEKSAVKN PDVFANYDVI MRNDHIGQNA KAPVDYYMLA LSWSPGFCDI
     QREKYGDQLP YSSQYQCGNN RTFGWVVHGL WPQNANARAV SDHPRFCKGD LPALPKGLLA
     QYLAISPGEK LLQGEWEKHG SCAFDSAQQY FAKEQELFNA LKLPNQKLSR DELFGWMKQH
     NPQLKNAYLR ASRNELFICY DKKWQVMNCQ SK