ID   RN2LT_RANLT             Reviewed;          28 AA.
AC   C0HLX8;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 1.
DT   03-AUG-2022, entry version 3.
DE   RecName: Full=Ranatuerin-2LT {ECO:0000303|PubMed:27071218};
OS   Rana latastei (Italian agile frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=151453;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR
RP   LOCATION, TISSUE SPECIFICITY, AND DISULFIDE BOND.
RX   PubMed=27071218; DOI=10.1002/rcm.7436;
RA   Samgina T.Y., Tolpina M.D., Trebse P., Torkar G., Artemenko K.A.,
RA   Bergquist J., Lebedev A.T.;
RT   "LTQ Orbitrap Velos in routine de novo sequencing of non-tryptic skin
RT   peptides from the frog Rana latastei with traditional and reliable manual
RT   spectra interpretation.";
RL   Rapid Commun. Mass Spectrom. 30:265-276(2016).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250|UniProtKB:P86161}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27071218}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:27071218}.
CC   -!- MASS SPECTROMETRY: Mass=2892.57; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:27071218};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Ranatuerin subfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   Pfam; PF08023; Antimicrobial_2; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           1..28
FT                   /note="Ranatuerin-2LT"
FT                   /id="PRO_0000454218"
FT   DISULFID        23..28
FT                   /evidence="ECO:0000269|PubMed:27071218"
FT   UNSURE          2
FT                   /note="Assigned by comparison with orthologs"
FT                   /evidence="ECO:0000305|PubMed:27071218"
FT   UNSURE          6
FT                   /note="Assigned by comparison with orthologs"
FT                   /evidence="ECO:0000305|PubMed:27071218"
FT   UNSURE          13
FT                   /note="Assigned by comparison with orthologs"
FT                   /evidence="ECO:0000305|PubMed:27071218"
FT   UNSURE          18
FT                   /note="Assigned by comparison with orthologs"
FT                   /evidence="ECO:0000305|PubMed:27071218"
FT   UNSURE          21
FT                   /note="Assigned by comparison with orthologs"
FT                   /evidence="ECO:0000305|PubMed:27071218"
SQ   SEQUENCE   28 AA;  2896 MW;  B5964EE47C50A5A2 CRC64;
     GLMDVLKGAA KNLFASALDK LKCKVTGC