ID   RN2PA_LITPI             Reviewed;          70 AA.
AC   Q8QFQ3;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Ranatuerin-2Pa;
DE   Flags: Precursor;
OS   Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8404;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skin;
RX   PubMed=12413397; DOI=10.1042/bj20021343;
RA   Chen T., Farragher S.M., Bjourson A.J., Orr D.F., Rao P., Shaw C.;
RT   "Granular gland transcriptomes in stimulated amphibian skin secretions.";
RL   Biochem. J. 371:125-130(2003).
CC   -!- FUNCTION: Antimicrobial peptide. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000305}.
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DR   EMBL; AJ427748; CAD20747.1; -; mRNA.
DR   AlphaFoldDB; Q8QFQ3; -.
DR   SMR; Q8QFQ3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   Pfam; PF08023; Antimicrobial_2; 1.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
PE   2: Evidence at transcript level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Cleavage on pair of basic residues; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..39
FT                   /id="PRO_0000003469"
FT   PEPTIDE         40..68
FT                   /note="Ranatuerin-2Pa"
FT                   /id="PRO_0000003470"
FT   DISULFID        62..68
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   70 AA;  7679 MW;  F490C439BC4DD9F8 CRC64;
     MFTLKKSLLL LFFLGTISLS LCQREADDDQ GEVQQEVKRG FLSTVKNLAT NVAGTVIDTI
     KCKVTGGCRK