RNA14_ASPFU
ID RNA14_ASPFU Reviewed; 1029 AA.
AC Q4WXX4;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=mRNA 3'-end-processing protein rna14;
GN Name=rna14; ORFNames=AFUA_3G11020;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Component of the cleavage factor IA (CFIA) complex, which is
CC involved in the endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Nucleus and/or cytoplasm. {ECO:0000250}.
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DR EMBL; AAHF01000002; EAL92479.1; -; Genomic_DNA.
DR RefSeq; XP_754517.1; XM_749424.1.
DR AlphaFoldDB; Q4WXX4; -.
DR SMR; Q4WXX4; -.
DR STRING; 746128.CADAFUBP00003734; -.
DR EnsemblFungi; EAL92479; EAL92479; AFUA_3G11020.
DR GeneID; 3511720; -.
DR KEGG; afm:AFUA_3G11020; -.
DR VEuPathDB; FungiDB:Afu3g11020; -.
DR eggNOG; KOG1914; Eukaryota.
DR HOGENOM; CLU_007630_1_1_1; -.
DR InParanoid; Q4WXX4; -.
DR OMA; WSVYLDY; -.
DR OrthoDB; 331411at2759; -.
DR Proteomes; UP000002530; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:InterPro.
DR GO; GO:0031123; P:RNA 3'-end processing; IBA:GO_Central.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045243; Rna14-like.
DR InterPro; IPR008847; Suf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR19980; PTHR19980; 1.
DR Pfam; PF05843; Suf; 1.
DR SMART; SM00386; HAT; 6.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..1029
FT /note="mRNA 3'-end-processing protein rna14"
FT /id="PRO_0000238518"
FT REPEAT 281..313
FT /note="HAT 1"
FT REPEAT 315..346
FT /note="HAT 2"
FT REPEAT 357..392
FT /note="HAT 3"
FT REPEAT 406..439
FT /note="HAT 4"
FT REPEAT 469..509
FT /note="HAT 5"
FT REPEAT 521..553
FT /note="HAT 6"
FT REGION 1..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..918
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1020
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1029 AA; 115313 MW; E5BC2DB088F65EB2 CRC64;
MAEEDAEKAF FQAQTMNAES VDYKAVEEHG ADSSDSDDYD PSKTLQDQYS SSMTDLKQSE
NVSSSASPEP NPTEQNSVQP DHDPSQPDGA SYPSQTPPRD ESRTSTMVPT SGTSVQPKTR
TIGGFVVEDE DEDDAGDADY EPPAVLGVED MNTVATNVPQ QSVSGNENEA SSTPDVSLDD
AAQQSASLNN VSHNSYSPAP AVAPKSDVAV AAGQSLYNSH ALQSGNVQDS ATATPTPDSP
STSKGRLPHD RVGILEDRIQ EDPRGDIPAW LELINEHRSR NRFDSARDVF ERFLKVFPFA
AEQWVAYAKM ESELNDLYRL EQIFNRTLLT IPDVQLWSVY LDYVRRRNPL TTDTTGQARR
IISSAYELAF QHIGVDKDSG SIWSDYVQFI KSGPGNVGGS GWQDQQKMDL LRKAYQKAIC
VPTQAVNTLW KEYDQFEMGL NKLTGRKFLQ EQSPAYMTAR SSYTELQNIT RDLIRTTLPR
LPPVPGSDGD IEFTQQVDIW KRWIKWEKGD PLVLKEEDPA AFKGRVVYVY KQALMALRFL
PEMWFDAAEF CFLNDLESEG NEFLKQGMEA NPESCLLAFK RADRLEITSE SEQDPIKRGA
KVREPYDKLL DALYDLIAKA RTREAQDVAR LEETFAKMNA DNPPAKTDDD DDDQSESKAR
ESVKNAQIDA VRKAHAIQIG ILSKTISFAW IALMRAMRRI QGKGKPGETP GSRQVFADAR
KRGRITSDVY IASALIEYHC YKDPAATKIF ERGAKLFPDD ENFALEYLKH LIDINDIINA
RAVFEMTVRK LASNPDNVHK TKPIFAFLHE YESRYGDLVQ VINLENRMRE LFPEDPTLEQ
FAHRYSAPTF DPTAVRPIIS PSQMRPKAVF PTSEQPMSRH GTPTPRYPGS VTDSPKRPLE
DFDDDYNRPR KFVRAESPLK TSQRRQLDQQ KRSQLSNVQT GSQFRSQGSP APLPRDIVHL
LSIIPPASAY TAGRFSPEKL VDLIRRIEMP SSISQIPLPQ SARGLGTTQT PMQPFSGKAS
PSLSVRAVY
