RNA14_CRYNJ
ID RNA14_CRYNJ Reviewed; 1064 AA.
AC P0CO12; Q55XQ2; Q5KM87;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=mRNA 3'-end-processing protein RNA14;
GN Name=RNA14; OrderedLocusNames=CNB02560;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Component of the cleavage factor IA (CFIA) complex, which is
CC involved in the endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Nucleus and/or cytoplasm. {ECO:0000250}.
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DR EMBL; AE017342; AAW41872.1; -; Genomic_DNA.
DR RefSeq; XP_569179.1; XM_569179.1.
DR AlphaFoldDB; P0CO12; -.
DR SMR; P0CO12; -.
DR STRING; 5207.AAW41872; -.
DR PaxDb; P0CO12; -.
DR EnsemblFungi; AAW41872; AAW41872; CNB02560.
DR GeneID; 3255985; -.
DR KEGG; cne:CNB02560; -.
DR VEuPathDB; FungiDB:CNB02560; -.
DR eggNOG; KOG1914; Eukaryota.
DR HOGENOM; CLU_007630_0_0_1; -.
DR InParanoid; P0CO12; -.
DR OMA; WSVYLDY; -.
DR OrthoDB; 331411at2759; -.
DR Proteomes; UP000002149; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:InterPro.
DR GO; GO:0031123; P:RNA 3'-end processing; IBA:GO_Central.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045243; Rna14-like.
DR InterPro; IPR008847; Suf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR19980; PTHR19980; 1.
DR Pfam; PF05843; Suf; 1.
DR SMART; SM00386; HAT; 6.
DR SUPFAM; SSF48452; SSF48452; 2.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..1064
FT /note="mRNA 3'-end-processing protein RNA14"
FT /id="PRO_0000238522"
FT REPEAT 327..364
FT /note="HAT 1"
FT REPEAT 377..412
FT /note="HAT 2"
FT REPEAT 423..456
FT /note="HAT 3"
FT REPEAT 673..706
FT /note="HAT 4"
FT REPEAT 777..811
FT /note="HAT 5"
FT REGION 34..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..903
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..968
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1045
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1064
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1064 AA; 116928 MW; 853F848BE1EA47F4 CRC64;
MSHEHPAEIV HQLQSIDSIQ QDLADTAAAV VDAASQSLPP QHAAQDQKSH STLLDNAEAM
ESILESAIPA APGSSSTAAA SDAIGDNNFT ASGPPPISNT VVAPSAADDE TGDVIVVESE
TPTTTNVVEA VVNPENDGDV PIESTEQSSG QPAEQPTEQP TEQPTEQPAE QPAVETPQAP
QSTPAAPAAS AVESIPTTLE ETHLEQIVQA PAPTVHTEPL TPVVDIKMEE KPMIEHVAWI
PPQGIHSDVF LPEGLTEYSP SVSQNGELIR SWRADPSNPT LLLSLFNWAV QKTEVEDARA
WYRVLAVDNP TAAQPLLALI NLELALSNFA EVEAIFASTL KGSAGITTAA DVSIWAAYLH
YIRRQNPLTE GSANAADVRS TITEAYEFAL RECGFDRESG DIWDEYIKFV ASGPATNQWD
TQAKNDNLRK IYQRAVCIPL NNIEALWKSY DNFESSLNKL TAKKYLAEKS PAYMTARTAL
RELRALSDPI PKPILPPYPT FTEQDRQVVG AWKACLRWEE GNPLVIENHE LLQSRIGYAL
RKCLGEMRHF PELWHYAASY YSKLGKQDEA AEILEAGVNA CPKSFLLTFA YAELQEERKA
FPTCHSLYTT LISKLNPEVD ELRQNVAREI DIARGPPIPG SEKAAVAAAV GDSIDADGND
ISDIQRLVEE REQRGALVAQ RRGKDIEELM VGISVVWIMY MRFARRAEGI KAARGVFGKA
RKSPHLTWQV FEASALMEYH TNKDAAVAIR IFELGLKQFS EDVDYVIKYL QFLLSINDDN
NARALFERSV VRIMGDKARP LWDAWARYEY TYGDLSAVHK LEARMSEVFP EDAPLKRFAQ
RWSYNGIDQI AIRDLGFNRA RMGVAAPPAF AIAPVLPPVH ASIPAPIAVP TPVQPPQESY
KRPAPEDIPP RRPSSAEFSR SPKRHRAQSP PRRYPERDDR PPPGRYRDSL PPVKAPSSIP
PPPLAGPAYA TPSSGAYGGD KDRSGLEKPL AWFMAQLPNA RSFDGPVFRP DDIMKLFGGL
SLPGAGMPPA PPISRGPPPP PMQSRGYYEP ERDRRYGGHG SGRY
