RNA14_KLULA
ID RNA14_KLULA Reviewed; 661 AA.
AC Q6CII8;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=mRNA 3'-end-processing protein RNA14;
GN Name=RNA14; OrderedLocusNames=KLLA0F26290g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the cleavage factor IA (CFIA) complex, which is
CC involved in the endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Nucleus and/or cytoplasm. {ECO:0000250}.
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DR EMBL; CR382126; CAG98959.1; -; Genomic_DNA.
DR RefSeq; XP_456251.1; XM_456251.1.
DR PDB; 4E6H; X-ray; 2.30 A; A=18-661.
DR PDB; 4E85; X-ray; 3.00 A; A/B=18-661.
DR PDB; 4EBA; X-ray; 3.30 A; A/B/C/D/E/F=18-661.
DR PDBsum; 4E6H; -.
DR PDBsum; 4E85; -.
DR PDBsum; 4EBA; -.
DR AlphaFoldDB; Q6CII8; -.
DR SMR; Q6CII8; -.
DR STRING; 28985.XP_456251.1; -.
DR EnsemblFungi; CAG98959; CAG98959; KLLA0_F26290g.
DR GeneID; 2894835; -.
DR KEGG; kla:KLLA0_F26290g; -.
DR eggNOG; KOG1914; Eukaryota.
DR HOGENOM; CLU_007630_0_1_1; -.
DR InParanoid; Q6CII8; -.
DR OMA; PKRQYFK; -.
DR Proteomes; UP000000598; Chromosome F.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR GO; GO:0005849; C:mRNA cleavage factor complex; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:EnsemblFungi.
DR GO; GO:0006378; P:mRNA polyadenylation; IEA:EnsemblFungi.
DR GO; GO:0098789; P:pre-mRNA cleavage required for polyadenylation; IEA:EnsemblFungi.
DR GO; GO:0072423; P:response to DNA damage checkpoint signaling; IEA:EnsemblFungi.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045243; Rna14-like.
DR InterPro; IPR008847; Suf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR19980; PTHR19980; 1.
DR Pfam; PF05843; Suf; 1.
DR SMART; SM00386; HAT; 7.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; mRNA processing; Nucleus; Reference proteome;
KW Repeat.
FT CHAIN 1..661
FT /note="mRNA 3'-end-processing protein RNA14"
FT /id="PRO_0000238526"
FT REPEAT 62..94
FT /note="HAT 1"
FT REPEAT 99..133
FT /note="HAT 2"
FT REPEAT 143..179
FT /note="HAT 3"
FT REPEAT 190..223
FT /note="HAT 4"
FT REPEAT 264..296
FT /note="HAT 5"
FT REPEAT 305..337
FT /note="HAT 6"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT TURN 23..26
FT /evidence="ECO:0007829|PDB:4E85"
FT HELIX 33..43
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 48..60
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 64..77
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 82..93
FT /evidence="ECO:0007829|PDB:4E6H"
FT TURN 94..97
FT /evidence="ECO:0007829|PDB:4E85"
FT HELIX 101..111
FT /evidence="ECO:0007829|PDB:4E6H"
FT STRAND 114..116
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 121..134
FT /evidence="ECO:0007829|PDB:4E6H"
FT TURN 138..140
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 141..158
FT /evidence="ECO:0007829|PDB:4E6H"
FT TURN 159..162
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 164..166
FT /evidence="ECO:0007829|PDB:4E85"
FT HELIX 167..178
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 185..202
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 210..224
FT /evidence="ECO:0007829|PDB:4E6H"
FT TURN 226..228
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 229..253
FT /evidence="ECO:0007829|PDB:4E6H"
FT TURN 254..256
FT /evidence="ECO:0007829|PDB:4E6H"
FT STRAND 263..265
FT /evidence="ECO:0007829|PDB:4E6H"
FT TURN 270..272
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 281..295
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 303..320
FT /evidence="ECO:0007829|PDB:4E6H"
FT TURN 321..323
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 325..338
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 344..355
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 360..372
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 376..400
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 405..430
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 432..444
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 445..448
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 452..462
FT /evidence="ECO:0007829|PDB:4E6H"
FT TURN 463..465
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 469..482
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 486..499
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 502..512
FT /evidence="ECO:0007829|PDB:4E6H"
FT TURN 513..515
FT /evidence="ECO:0007829|PDB:4E6H"
FT STRAND 516..518
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 521..535
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 540..552
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 558..565
FT /evidence="ECO:0007829|PDB:4E6H"
FT HELIX 573..577
FT /evidence="ECO:0007829|PDB:4E6H"
FT TURN 628..633
FT /evidence="ECO:0007829|PDB:4EBA"
FT HELIX 648..650
FT /evidence="ECO:0007829|PDB:4EBA"
FT TURN 651..656
FT /evidence="ECO:0007829|PDB:4EBA"
SQ SEQUENCE 661 AA; 77593 MW; B6596DAEEAF147CC CRC64;
MSDGTATPDP LPSSSNTSTS LRPTSRVRDE SDVIGKLNDM IEEQPTDIFL YVKLLKHHVS
LKQWKQVYET FDKLHDRFPL MANIWCMRLS LEFDKMEELD AAVIEPVLAR CLSKELGNND
LSLWLSYITY VRKKNDIITG GEEARNIVIQ AFQVVVDKCA IFEPKSIQFW NEYLHFLEHW
KPVNKFEEQQ RVQYIRKLYK TLLCQPMDCL ESMWQRYTQW EQDVNQLTAR RHIGELSAQY
MNARSLYQDW LNITKGLKRN LPITLNQATE SNLPKPNEYD VQQLLIWLEW IRWESDNKLE
LSDDLHKARM TYVYMQAAQH VCFAPEIWFN MANYQGEKNT DSTVITKYLK LGQQCIPNSA
VLAFSLSEQY ELNTKIPEIE TTILSCIDRI HLDLAALMED DPTNESAINQ LKSKLTYVYC
VYMNTMKRIQ GLAASRKIFG KCRRLKKLVT PDIYLENAYI EYHISKDTKT ACKVLELGLK
YFATDGEYIN KYLDFLIYVN EESQVKSLFE SSIDKISDSH LLKMIFQKVI FFESKVGSLN
SVRTLEKRFF EKFPEVNKLE EFTNKYKVLD VNYLQRLELD YMVRDVMPEA IALDRGSNNL
KRTMREEEDG QAFKKFKANE DPIPPEIVEL LKVLPKRQYF KVTIFEAHAF SEFLSDKVTI
Q
