RNA14_NEUCR
ID RNA14_NEUCR Reviewed; 1167 AA.
AC Q7S1Y0;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=mRNA 3'-end-processing protein rna-14;
GN Name=rna-14; ORFNames=NCU09435;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Component of the cleavage factor IA (CFIA) complex, which is
CC involved in the endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Nucleus and/or cytoplasm. {ECO:0000250}.
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DR EMBL; CM002242; EAA29351.1; -; Genomic_DNA.
DR RefSeq; XP_958587.1; XM_953494.2.
DR AlphaFoldDB; Q7S1Y0; -.
DR SMR; Q7S1Y0; -.
DR STRING; 5141.EFNCRP00000009229; -.
DR PRIDE; Q7S1Y0; -.
DR EnsemblFungi; EAA29351; EAA29351; NCU09435.
DR GeneID; 3874734; -.
DR KEGG; ncr:NCU09435; -.
DR VEuPathDB; FungiDB:NCU09435; -.
DR HOGENOM; CLU_007630_1_1_1; -.
DR InParanoid; Q7S1Y0; -.
DR OMA; WSVYLDY; -.
DR Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:InterPro.
DR GO; GO:0031123; P:RNA 3'-end processing; IBA:GO_Central.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045243; Rna14-like.
DR InterPro; IPR008847; Suf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR19980; PTHR19980; 1.
DR Pfam; PF05843; Suf; 1.
DR SMART; SM00386; HAT; 5.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..1167
FT /note="mRNA 3'-end-processing protein rna-14"
FT /id="PRO_0000238527"
FT REPEAT 277..309
FT /note="HAT 1"
FT REPEAT 311..342
FT /note="HAT 2"
FT REPEAT 352..387
FT /note="HAT 3"
FT REPEAT 401..434
FT /note="HAT 4"
FT REPEAT 471..504
FT /note="HAT 5"
FT REPEAT 518..550
FT /note="HAT 6"
FT REGION 1..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..137
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1167 AA; 128491 MW; CB784B80FD403681 CRC64;
MSDDYDPTNI NAASWEEQED YGEADGSEQY GEAEGSEQQD IQHSSEHQEA EYSVESNPND
LGDHPSQDGN TDDVGDDYDP ASVVTSSVPA PPSAPAQEDS KTAPQPAAPV AKKPRTAGGF
LVGDSDDEDE DGDDDGEPQQ QQQQQQQQQP HQVVHKETGS GASSSGGSAP APASASATAA
PQSHSPAPQT ATLTVQDNAG ATTFNAPPVP QQVSHQSGAT TAAVPTTPSS AAPAVDPTPV
TQPAPDRVAI YEDQIRDDPR GAMNAWLELM KEKRARNDID GARQVYERFL AIFPQAADIW
VEYLDLELSL NNFPQAEGIF AKCLMTTPNV NLWTRYLDYI RRRNDLNDST GQARQTVSQA
YEFVIDNIGL DKDSGKIWAE YIQFIKFGPG TVGGSQWQDQ QKMDQLRKAY QRAICVPISN
VNTLWKEYDQ FEMGLNKLTG RKYLSEKSPS YMSAKSANTA LEHITRGLNR TNLPRLPPAP
GFDGDQEFME QVEIWKKWIA WEKSDPLDLK DDKDQPGLYQ KRILYVYNQA LMALRFWPEM
WVDAAQWCFD NNITTVENKV TKDGNANGVE FLIRGIEANP ESVLLAFKHA DHIESTYPIE
ENDEAKIQRG EAVKAPYNKV LDTLYAMIKS LKEKEAAQIA KLQEMTAAQE SKAGSDNEDG
DGAADNIKKA PIEAIQKGYA AQTQLLSRMI SFVWIALIRA MRRVQGKGGL NVPLGGMRKA
FHDARARGRL TSDVYAAVAQ LEWTIYKDPA GGKIFDRGAK LFPEDENFTL ENIKYLHSRD
DHTNARVLFE TVVNRLTQKP ELVHKAKPLY QYFHKYESQF GELAQVTKLE KRMAELFPED
PKLAAFTARY ASDKFDPITA RIIVSPTTQL RPKNMIMPSI EQQQPQLPMS QRDTPAAGFS
PRPQGLKSPS AGPGAPFAPY AAKRPLDDRD YDDHPRKIAR SEHDPFVRGA SPLKGAAGRR
LDQQRRMGGA AGAYSGSGAG SQVAPIARDI TFLLSQIPRV EFYDSHRLNP SRMVSLLQNV
KVPEYLDWKR ERERMQQMQQ MQGDGYGGYG GGGGGGGGGG YQGGGHARNI SQDYAYRESP
GPLGGRPLSP FTGGPGSRLA SATAAYRQAP VGRPESSGSY EPPPAAQYGV PPPAQYDGGW
AQQQQQQQYG QPPAPQGYRY GNPPPPY
