RNAS1_BOVIN
ID RNAS1_BOVIN Reviewed; 150 AA.
AC P61823; A6QPW8; P00656; Q9TSF2;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Ribonuclease pancreatic;
DE EC=4.6.1.18;
DE AltName: Full=RNase 1;
DE AltName: Full=RNase A;
DE Flags: Precursor;
GN Name=RNASE1; Synonyms=RNS1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2838818; DOI=10.1093/nar/16.12.5491;
RA Carsana A., Confalone E., Palmieri M., Libonati M., Furia A.;
RT "Structure of the bovine pancreatic ribonuclease gene: the unique
RT intervening sequence in the 5' untranslated region contains a promoter-like
RT element.";
RL Nucleic Acids Res. 16:5491-5502(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal pancreas;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 23-150, AND FUNCTION.
RX PubMed=7479688; DOI=10.1093/protein/8.3.261;
RA Delcardayre S.B., Ribo M., Yokel E.M., Quirk D.J., Rutter W.J.,
RA Raines R.T.;
RT "Engineering ribonuclease A: production, purification and characterization
RT of wild-type enzyme and mutants at Gln11.";
RL Protein Eng. 8:261-273(1995).
RN [4]
RP PROTEIN SEQUENCE OF 27-150, AND DISULFIDE BONDS.
RC TISSUE=Pancreas;
RX PubMed=13989651;
RA Smyth D.G., Stein W.H., Moore S.;
RT "The sequence of amino acid residues in bovine pancreatic ribonuclease:
RT revisions and confirmations.";
RL J. Biol. Chem. 238:227-234(1963).
RN [5]
RP PROTEIN SEQUENCE OF 27-150.
RC TISSUE=Pancreas;
RX PubMed=14235531;
RA Plummer T.H. Jr., Hirs C.H.W.;
RT "On the structure of bovine pancreatic ribonuclease B. Isolation of a
RT glycopeptide.";
RL J. Biol. Chem. 239:2530-2538(1964).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-150.
RX PubMed=8587129; DOI=10.1007/bf00173164;
RA Confalone E., Beintema J.J., Sasso M.P., Carsana A., Palmieri M.,
RA Vento M.T., Furia A.;
RT "Molecular evolution of genes encoding ribonucleases in ruminant species.";
RL J. Mol. Evol. 41:850-858(1995).
RN [7]
RP ACTIVE SITE.
RX PubMed=14342316;
RA Heinrikson R.L., Stein W.H., Crestfield A.M., Moore S.;
RT "The reactivities of the histidine residues at the active site of
RT ribonuclease toward halo acids of different structures.";
RL J. Biol. Chem. 240:2921-2934(1965).
RN [8]
RP ACTIVE SITE.
RX PubMed=5801478; DOI=10.1016/0022-2836(69)90389-1;
RA Shall S., Barnard E.A.;
RT "Heavy atom-labelled derivatives of bovine pancreatic ribonuclease. I.
RT Specific reactions of ribonuclease with N-acetylhomocysteine thiolactone
RT and silver ion.";
RL J. Mol. Biol. 41:237-251(1969).
RN [9]
RP GLYCATION AT LYS-27; LYS-33; LYS-63 AND LYS-67.
RX PubMed=4030761; DOI=10.1016/s0021-9258(19)85131-1;
RA Watkins N.G., Thorpe S.R., Baynes J.W.;
RT "Glycation of amino groups in protein. Studies on the specificity of
RT modification of RNase by glucose.";
RL J. Biol. Chem. 260:10629-10636(1985).
RN [10]
RP DNA-BINDING.
RX PubMed=3961503; DOI=10.1126/science.3961503;
RA McPherson A., Brayer G., Cascio D., Williams R.;
RT "The mechanism of binding of a polynucleotide chain to pancreatic
RT ribonuclease.";
RL Science 232:765-768(1986).
RN [11]
RP GLYCOSYLATION AT ASN-60.
RX PubMed=19358553; DOI=10.1021/ac900231w;
RA Thaysen-Andersen M., Mysling S., Hojrup P.;
RT "Site-specific glycoprofiling of N-linked glycopeptides using MALDI-TOF MS:
RT strong correlation between signal strength and glycoform quantities.";
RL Anal. Chem. 81:3933-3943(2009).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RX PubMed=5460889; DOI=10.1016/s0021-9258(18)63395-2;
RA Wyckoff H.W., Tsernoglou D., Hanson A.W., Knox J.R., Lee B., Richards F.M.;
RT "The three-dimensional structure of ribonuclease-S. Interpretation of an
RT electron density map at a nominal resolution of 2 A.";
RL J. Biol. Chem. 245:305-328(1970).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RX PubMed=4835726; DOI=10.1016/0022-2836(74)90125-9;
RA Carlisle C.H., Palmer R.A., Mazumdar S.K., Gorinsky B.A., Yeates D.G.R.;
RT "The structure of ribonuclease at 2.5-A resolution.";
RL J. Mol. Biol. 85:1-18(1974).
RN [14]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RX PubMed=6276380; DOI=10.1016/s0021-9258(19)68195-0;
RA Wlodawer A., Bott R., Sjoelin L.;
RT "The refined crystal structure of ribonuclease A at 2.0-A resolution.";
RL J. Biol. Chem. 257:1325-1332(1982).
RN [15]
RP X-RAY CRYSTALLOGRAPHY (1.26 ANGSTROMS).
RX PubMed=3401445; DOI=10.1021/bi00408a010;
RA Wlodawer A., Svensson L.A., Sjoelin L., Gilliland G.L.;
RT "Structure of phosphate-free ribonuclease A refined at 1.26 A.";
RL Biochemistry 27:2705-2717(1988).
RN [16]
RP X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
RX PubMed=9154942; DOI=10.1021/bi9700330;
RA Leonidas D.D., Shapiro R., Irons L.I., Russo N., Acharya K.R.;
RT "Crystal structures of ribonuclease A complexes with 5'-diphosphoadenosine
RT 3'-phosphate and 5'-diphosphoadenosine 2'-phosphate at 1.7-A resolution.";
RL Biochemistry 36:5578-5588(1997).
RN [17]
RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 2-125 OF MUTANT GLY-67.
RX PubMed=11087402; DOI=10.1021/bi001862f;
RA Kelemen B.R., Schultz L.W., Sweeney R.Y., Raines R.T.;
RT "Excavating an active site: the nucleobase specificity of ribonuclease A.";
RL Biochemistry 39:14487-14494(2000).
RN [18]
RP X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF MUTANTS ALA-38 AND ALA-145.
RX PubMed=11305910; DOI=10.1021/bi0100182;
RA Park C., Schultz L.W., Raines R.T.;
RT "Contribution of the active site histidine residues of ribonuclease A to
RT nucleic acid binding.";
RL Biochemistry 40:4949-4956(2001).
RN [19]
RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOG.
RX PubMed=11513604; DOI=10.1021/bi010888j;
RA Jardine A.M., Leonidas D.D., Jenkins J.L., Park C., Raines R.T.,
RA Acharya K.R., Shapiro R.;
RT "Cleavage of 3',5'-pyrophosphate-linked dinucleotides by ribonuclease A and
RT angiogenin.";
RL Biochemistry 40:10262-10272(2001).
RN [20]
RP X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF MUTANTS ALA-120; PHE-120 AND
RP TRP-120.
RX PubMed=11742124; DOI=10.1110/ps.31102;
RA Chatani E., Hayashi R., Moriyama H., Ueki T.;
RT "Conformational strictness required for maximum activity and stability of
RT bovine pancreatic ribonuclease A as revealed by crystallographic study of
RT three Phe120 mutants at 1.4 A resolution.";
RL Protein Sci. 11:72-81(2002).
RN [21]
RP STRUCTURE BY NMR.
RX PubMed=2775743; DOI=10.1021/bi00440a033;
RA Robertson A.D., Purisima E.O., Eastman M.A., Scheraga H.A.;
RT "Proton NMR assignments and regular backbone structure of bovine pancreatic
RT ribonuclease A in aqueous solution.";
RL Biochemistry 28:5930-5938(1989).
RN [22]
RP STRUCTURE BY NMR.
RX PubMed=2776756; DOI=10.1111/j.1432-1033.1989.tb21092.x;
RA Rico M., Bruix M., Santoro J., Gonzalez C., Neira J.L., Nieto J.L.,
RA Herranz J.;
RT "Sequential 1H-NMR assignment and solution structure of bovine pancreatic
RT ribonuclease A.";
RL Eur. J. Biochem. 183:623-638(1989).
RN [23]
RP STRUCTURE BY NMR.
RX PubMed=1841699; DOI=10.1007/bf01875521;
RA Rico M., Santoro J., Gonzalez C., Bruix M., Neira J.L., Nieto J.L.,
RA Herranz J.;
RT "3D structure of bovine pancreatic ribonuclease A in aqueous solution: an
RT approach to tertiary structure determination from a small basis of 1H NMR
RT NOE correlations.";
RL J. Biomol. NMR 1:283-298(1991).
CC -!- FUNCTION: Endonuclease that catalyzes the cleavage of RNA on the 3'
CC side of pyrimidine nucleotides. Acts on single-stranded and double-
CC stranded RNA. {ECO:0000269|PubMed:7479688}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-
CC phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].; EC=4.6.1.18;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'-
CC phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].; EC=4.6.1.18;
CC -!- SUBUNIT: Interacts with and forms tight 1:1 complexes with RNH1.
CC Dimerization of two such complexes may occur. Interaction with RNH1
CC inhibits this protein (By similarity). Monomer. {ECO:0000250,
CC ECO:0000269|PubMed:11513604}.
CC -!- INTERACTION:
CC P61823; Q80UW2: Fbxo2; Xeno; NbExp=2; IntAct=EBI-908364, EBI-2314714;
CC P61823; P17967: PDI1; Xeno; NbExp=2; IntAct=EBI-908364, EBI-13012;
CC P61823; P13489: RNH1; Xeno; NbExp=3; IntAct=EBI-908364, EBI-1237106;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Pancreas.
CC -!- MISCELLANEOUS: Ribonuclease can destabilize or unwind the DNA helix by
CC complexing with single-stranded DNA; this complex arises by an extended
CC multisite cation-anion interaction between the lysine and arginine
CC residues of the enzyme and the phosphate groups of the nucleotides.
CC -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Worthington enzyme manual;
CC URL="https://www.worthington-biochem.com/RNASE/";
CC -!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
CC Note=RNase A;
CC URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_oth_other_805";
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DR EMBL; X07283; CAA30263.1; -; Genomic_DNA.
DR EMBL; BC149529; AAI49530.1; -; mRNA.
DR EMBL; BC149636; AAI49637.1; -; mRNA.
DR EMBL; S80747; AAB35594.1; -; mRNA.
DR EMBL; S81740; AAB36134.1; -; Genomic_DNA.
DR PIR; S00897; NRBO.
DR RefSeq; NP_001014408.2; NM_001014386.4.
DR RefSeq; XP_005211519.1; XM_005211462.2.
DR PDB; 1A2W; X-ray; 2.10 A; A/B=27-150.
DR PDB; 1A5P; X-ray; 1.60 A; A=27-150.
DR PDB; 1A5Q; X-ray; 2.30 A; A=27-150.
DR PDB; 1AFK; X-ray; 1.70 A; A/B=27-150.
DR PDB; 1AFL; X-ray; 1.70 A; A/B=27-150.
DR PDB; 1AFU; X-ray; 2.00 A; A/B=27-150.
DR PDB; 1AQP; X-ray; 2.00 A; A=27-150.
DR PDB; 1B6V; X-ray; 2.00 A; A/B=27-150.
DR PDB; 1BEL; X-ray; 1.60 A; A=27-150.
DR PDB; 1BZQ; X-ray; 2.80 A; A/B/C/D=27-150.
DR PDB; 1C0B; X-ray; 1.90 A; A=23-150.
DR PDB; 1C0C; X-ray; 2.00 A; A=23-150.
DR PDB; 1C8W; X-ray; 1.80 A; A=27-150.
DR PDB; 1C9V; X-ray; 1.70 A; A=27-150.
DR PDB; 1C9X; X-ray; 1.80 A; A=27-150.
DR PDB; 1CJQ; X-ray; 3.00 A; A=27-41, B=50-150.
DR PDB; 1CJR; X-ray; 2.30 A; A=27-41, B=50-150.
DR PDB; 1D5D; X-ray; 2.25 A; A=27-41, B=50-150.
DR PDB; 1D5E; X-ray; 2.25 A; A=27-41, B=50-150.
DR PDB; 1D5H; X-ray; 2.25 A; A=27-41, B=50-150.
DR PDB; 1DFJ; X-ray; 2.50 A; E=27-150.
DR PDB; 1DY5; X-ray; 0.87 A; A/B=27-150.
DR PDB; 1EIC; X-ray; 1.40 A; A=27-150.
DR PDB; 1EID; X-ray; 1.40 A; A=27-150.
DR PDB; 1EIE; X-ray; 1.40 A; A=27-150.
DR PDB; 1EOS; X-ray; 2.00 A; A/B=27-150.
DR PDB; 1EOW; X-ray; 2.00 A; A=27-150.
DR PDB; 1F0V; X-ray; 1.70 A; A/B/C/D=27-150.
DR PDB; 1FEV; X-ray; 2.25 A; A=27-41, B=50-150.
DR PDB; 1FS3; X-ray; 1.40 A; A=27-150.
DR PDB; 1GV7; X-ray; 2.10 A; A=84-99.
DR PDB; 1IZP; X-ray; 1.50 A; A=27-150.
DR PDB; 1IZQ; X-ray; 1.80 A; A=27-150.
DR PDB; 1IZR; X-ray; 1.50 A; A=27-150.
DR PDB; 1J7Z; X-ray; 2.25 A; A=27-41, B=47-150.
DR PDB; 1J80; X-ray; 2.10 A; A=27-41, B=47-150.
DR PDB; 1J81; X-ray; 2.20 A; A=27-41, B=47-150.
DR PDB; 1J82; X-ray; 2.30 A; A=27-41, B=47-150.
DR PDB; 1JN4; X-ray; 1.80 A; A/B=27-150.
DR PDB; 1JS0; X-ray; 2.20 A; A/B/C=27-150.
DR PDB; 1JVT; X-ray; 2.05 A; A/B=27-150.
DR PDB; 1JVU; X-ray; 1.78 A; A/B=27-150.
DR PDB; 1JVV; X-ray; 2.20 A; A/B=27-150.
DR PDB; 1KF2; X-ray; 1.10 A; A=27-150.
DR PDB; 1KF3; X-ray; 1.05 A; A=27-150.
DR PDB; 1KF4; X-ray; 1.10 A; A=27-150.
DR PDB; 1KF5; X-ray; 1.15 A; A=27-150.
DR PDB; 1KF7; X-ray; 1.15 A; A=27-150.
DR PDB; 1KF8; X-ray; 1.15 A; A=27-150.
DR PDB; 1KH8; X-ray; 2.00 A; A=27-150.
DR PDB; 1LSQ; X-ray; 1.90 A; A/B=27-150.
DR PDB; 1O0F; X-ray; 1.50 A; A/B=27-150.
DR PDB; 1O0H; X-ray; 1.20 A; A/B=27-150.
DR PDB; 1O0M; X-ray; 1.50 A; A/B=27-150.
DR PDB; 1O0N; X-ray; 1.50 A; A/B=27-150.
DR PDB; 1O0O; X-ray; 1.20 A; A/B=27-150.
DR PDB; 1QHC; X-ray; 1.70 A; A/B=27-150.
DR PDB; 1RAR; X-ray; 1.90 A; A=28-150.
DR PDB; 1RAS; X-ray; 1.70 A; A=28-150.
DR PDB; 1RAT; X-ray; 1.50 A; A=27-150.
DR PDB; 1RBB; X-ray; 2.50 A; A/B=27-150.
DR PDB; 1RBC; X-ray; 2.00 A; A=47-150, S=27-41.
DR PDB; 1RBD; X-ray; 1.70 A; A=47-150, S=27-41.
DR PDB; 1RBE; X-ray; 1.75 A; A=47-150, S=27-41.
DR PDB; 1RBF; X-ray; 1.80 A; A=47-150, S=27-41.
DR PDB; 1RBG; X-ray; 1.80 A; A=47-150, S=27-41.
DR PDB; 1RBH; X-ray; 1.70 A; A=47-150, S=27-41.
DR PDB; 1RBI; X-ray; 1.80 A; A=47-150, S=27-41.
DR PDB; 1RBJ; X-ray; 2.70 A; A=27-150.
DR PDB; 1RBN; X-ray; 2.10 A; A=27-150.
DR PDB; 1RBW; X-ray; 1.69 A; A=27-150.
DR PDB; 1RBX; X-ray; 1.69 A; A=27-150.
DR PDB; 1RCA; X-ray; 1.90 A; A=27-150.
DR PDB; 1RCN; X-ray; 2.32 A; E=27-150.
DR PDB; 1RHA; X-ray; 1.80 A; A=27-150.
DR PDB; 1RHB; X-ray; 1.50 A; A=27-150.
DR PDB; 1RNC; X-ray; 1.50 A; A=27-150.
DR PDB; 1RND; X-ray; 1.50 A; A=27-150.
DR PDB; 1RNM; X-ray; 2.00 A; E=27-150.
DR PDB; 1RNN; X-ray; 1.80 A; E=27-150.
DR PDB; 1RNO; X-ray; 1.90 A; A=27-150.
DR PDB; 1RNQ; X-ray; 2.00 A; A=27-150.
DR PDB; 1RNU; X-ray; 1.60 A; A=27-150.
DR PDB; 1RNV; X-ray; 1.60 A; A=27-150.
DR PDB; 1RNW; X-ray; 1.80 A; A=27-150.
DR PDB; 1RNX; X-ray; 1.90 A; A=27-150.
DR PDB; 1RNY; X-ray; 2.00 A; A=27-150.
DR PDB; 1RNZ; X-ray; 1.90 A; A=27-150.
DR PDB; 1ROB; X-ray; 1.60 A; A=27-150.
DR PDB; 1RPF; X-ray; 2.20 A; A=27-150.
DR PDB; 1RPG; X-ray; 1.40 A; A=27-150.
DR PDB; 1RPH; X-ray; 2.20 A; A=27-150.
DR PDB; 1RSM; X-ray; 2.00 A; A=27-150.
DR PDB; 1RTA; X-ray; 2.50 A; E=27-150.
DR PDB; 1RTB; X-ray; 2.50 A; A=27-150.
DR PDB; 1RUV; X-ray; 1.25 A; A=27-150.
DR PDB; 1SRN; X-ray; 1.80 A; A=27-144, B=137-150.
DR PDB; 1SSA; X-ray; 2.00 A; A=27-144, B=137-150.
DR PDB; 1SSB; X-ray; 2.00 A; A=27-144, B=137-150.
DR PDB; 1SSC; X-ray; 2.00 A; A=27-138, B=140-150.
DR PDB; 1U1B; X-ray; 2.00 A; A/B=27-150.
DR PDB; 1UN5; X-ray; 2.60 A; A=64-74.
DR PDB; 1W4O; X-ray; 1.60 A; A/B=27-150.
DR PDB; 1W4P; X-ray; 1.69 A; A/B=27-150.
DR PDB; 1W4Q; X-ray; 1.68 A; A/B=27-150.
DR PDB; 1WBU; X-ray; 1.90 A; A/B=27-150.
DR PDB; 1XPS; X-ray; 1.80 A; A/B=27-150.
DR PDB; 1XPT; X-ray; 1.90 A; A/B=27-150.
DR PDB; 1YMN; X-ray; 1.45 A; A=27-150.
DR PDB; 1YMR; X-ray; 1.50 A; A=27-150.
DR PDB; 1YMW; X-ray; 1.50 A; A=27-150.
DR PDB; 1Z3L; X-ray; 1.80 A; E=47-150, S=27-41.
DR PDB; 1Z3M; X-ray; 2.00 A; E=47-150, S=27-41.
DR PDB; 1Z3P; X-ray; 2.00 A; E=47-150, S=27-41.
DR PDB; 1Z6D; X-ray; 1.54 A; A/B=27-150.
DR PDB; 1Z6S; X-ray; 1.50 A; A/B=27-150.
DR PDB; 2AAS; NMR; -; A=27-150.
DR PDB; 2APQ; X-ray; 1.80 A; A=27-150.
DR PDB; 2BLP; X-ray; 1.40 A; A=27-150.
DR PDB; 2BLZ; X-ray; 1.40 A; A=27-150.
DR PDB; 2E33; X-ray; 2.70 A; B=27-150.
DR PDB; 2E3W; X-ray; 1.05 A; A=27-150.
DR PDB; 2G4W; X-ray; 1.84 A; A/B=27-150.
DR PDB; 2G4X; X-ray; 1.95 A; A=27-150.
DR PDB; 2G8Q; X-ray; 1.50 A; A/B=27-150.
DR PDB; 2G8R; X-ray; 1.70 A; A/B=27-150.
DR PDB; 2NUI; X-ray; 1.10 A; A=27-150.
DR PDB; 2OP2; X-ray; 1.60 A; A=27-150.
DR PDB; 2OQF; X-ray; 2.30 A; A/B/C/D=27-150.
DR PDB; 2P42; X-ray; 1.80 A; A/C=27-150.
DR PDB; 2P43; X-ray; 1.65 A; A=27-150.
DR PDB; 2P44; X-ray; 1.80 A; A=27-150.
DR PDB; 2P45; X-ray; 1.10 A; A=27-150.
DR PDB; 2P46; X-ray; 2.50 A; A/C=27-150.
DR PDB; 2P47; X-ray; 2.50 A; A=27-150.
DR PDB; 2P48; X-ray; 2.30 A; A=27-150.
DR PDB; 2P49; X-ray; 1.38 A; A=27-150.
DR PDB; 2P4A; X-ray; 1.90 A; A/C=27-150.
DR PDB; 2QCA; X-ray; 1.33 A; A=27-150.
DR PDB; 2RAT; X-ray; 1.50 A; A=27-150.
DR PDB; 2RLN; X-ray; 1.85 A; E=42-150, S=27-41.
DR PDB; 2RNS; X-ray; 1.60 A; A=27-150.
DR PDB; 2W5G; X-ray; 1.70 A; A/B=27-150.
DR PDB; 2W5I; X-ray; 2.40 A; A/B=27-150.
DR PDB; 2W5K; X-ray; 1.70 A; A/B=27-150.
DR PDB; 2W5L; X-ray; 1.70 A; A/B=27-150.
DR PDB; 2W5M; X-ray; 1.80 A; A/B=27-150.
DR PDB; 2XOG; X-ray; 1.72 A; A/B=27-150.
DR PDB; 2XOI; X-ray; 1.72 A; A/B=27-150.
DR PDB; 3A1R; Neutron; 1.70 A; A=27-150.
DR PDB; 3D6O; X-ray; 1.58 A; A/B=27-150.
DR PDB; 3D6P; X-ray; 1.60 A; A/B=27-150.
DR PDB; 3D6Q; X-ray; 1.60 A; A/B=27-150.
DR PDB; 3D7B; X-ray; 1.60 A; A/B=27-150.
DR PDB; 3D8Y; X-ray; 1.72 A; A/B=27-150.
DR PDB; 3D8Z; X-ray; 1.98 A; A/B=27-150.
DR PDB; 3DH5; X-ray; 1.60 A; A=27-150.
DR PDB; 3DH6; X-ray; 1.60 A; A=27-150.
DR PDB; 3DI7; X-ray; 1.60 A; A=27-150.
DR PDB; 3DI8; X-ray; 1.60 A; A=27-150.
DR PDB; 3DI9; X-ray; 2.00 A; A=27-150.
DR PDB; 3DIB; X-ray; 1.40 A; A=27-150.
DR PDB; 3DIC; X-ray; 1.60 A; A=27-150.
DR PDB; 3DXG; X-ray; 1.39 A; A/B=27-150.
DR PDB; 3DXH; X-ray; 1.40 A; A/B=27-150.
DR PDB; 3EUX; X-ray; 1.65 A; A/B=27-150.
DR PDB; 3EUY; X-ray; 1.95 A; A/B=27-150.
DR PDB; 3EUZ; X-ray; 1.84 A; A/B=27-150.
DR PDB; 3EV0; X-ray; 1.76 A; A/B=27-150.
DR PDB; 3EV1; X-ray; 2.00 A; A/B=27-150.
DR PDB; 3EV2; X-ray; 2.02 A; A/B=27-150.
DR PDB; 3EV3; X-ray; 1.68 A; A/B=27-150.
DR PDB; 3EV4; X-ray; 1.93 A; A/B=27-150.
DR PDB; 3EV5; X-ray; 1.68 A; A/B=27-150.
DR PDB; 3EV6; X-ray; 1.76 A; A/B=27-150.
DR PDB; 3FKZ; X-ray; 1.99 A; A/B=27-150.
DR PDB; 3FL0; X-ray; 1.94 A; A/B=27-150.
DR PDB; 3FL1; X-ray; 1.90 A; A/B=27-150.
DR PDB; 3FL3; X-ray; 1.60 A; A/B=27-150.
DR PDB; 3I67; X-ray; 1.30 A; A=27-150.
DR PDB; 3I6F; X-ray; 1.30 A; A=27-150.
DR PDB; 3I6H; X-ray; 1.30 A; A=27-150.
DR PDB; 3I6J; X-ray; 1.30 A; A=27-150.
DR PDB; 3I7W; X-ray; 2.35 A; A=27-150.
DR PDB; 3I7X; X-ray; 2.60 A; A=27-150.
DR PDB; 3I7Y; X-ray; 2.40 A; A=27-150.
DR PDB; 3JW1; X-ray; 1.60 A; A/B=27-150.
DR PDB; 3LXO; X-ray; 1.55 A; A=27-150.
DR PDB; 3MWQ; X-ray; 1.68 A; A=26-150.
DR PDB; 3MWR; X-ray; 1.85 A; A=27-150.
DR PDB; 3MX8; X-ray; 2.10 A; A=26-150.
DR PDB; 3MZQ; X-ray; 1.50 A; A=23-150.
DR PDB; 3MZR; X-ray; 1.50 A; A=23-150.
DR PDB; 3OQY; X-ray; 1.49 A; A/B=47-150, a/b=27-41.
DR PDB; 3OQZ; X-ray; 2.50 A; A/B=47-150, a/b=27-41.
DR PDB; 3OR0; X-ray; 2.30 A; A/B=47-150, a/b=27-41.
DR PDB; 3QL1; X-ray; 1.29 A; A=27-150.
DR PDB; 3QL2; X-ray; 1.49 A; A/B=27-150.
DR PDB; 3QSK; X-ray; 1.75 A; A=27-150.
DR PDB; 3RAT; X-ray; 1.50 A; A=27-150.
DR PDB; 3RH1; X-ray; 2.10 A; A=27-150.
DR PDB; 3RID; X-ray; 2.18 A; A/B/C/D=27-150.
DR PDB; 3RN3; X-ray; 1.45 A; A=27-150.
DR PDB; 3RSD; X-ray; 1.60 A; A=27-150.
DR PDB; 3RSK; X-ray; 2.00 A; A=27-150.
DR PDB; 3RSP; X-ray; 1.70 A; A=27-150.
DR PDB; 3SRN; X-ray; 2.00 A; A=27-139, B=140-146.
DR PDB; 4AO1; X-ray; 1.58 A; A=27-150.
DR PDB; 4G8V; X-ray; 1.70 A; A/B=27-150.
DR PDB; 4G8Y; X-ray; 1.80 A; A/B=27-150.
DR PDB; 4G90; X-ray; 1.90 A; A/B=27-150.
DR PDB; 4J5Z; X-ray; 1.80 A; A=27-150.
DR PDB; 4J60; X-ray; 1.69 A; A=27-150.
DR PDB; 4J61; X-ray; 1.69 A; A=27-150.
DR PDB; 4J62; X-ray; 2.04 A; A=27-150.
DR PDB; 4J63; X-ray; 2.04 A; A=27-150.
DR PDB; 4J64; X-ray; 1.78 A; A=27-150.
DR PDB; 4J65; X-ray; 1.96 A; A=27-150.
DR PDB; 4J66; X-ray; 2.04 A; A=27-150.
DR PDB; 4J67; X-ray; 1.86 A; A=27-150.
DR PDB; 4J68; X-ray; 1.78 A; A=27-150.
DR PDB; 4J69; X-ray; 1.89 A; A=27-150.
DR PDB; 4J6A; X-ray; 2.04 A; A=27-150.
DR PDB; 4K7L; X-ray; 1.38 A; A=27-41, B=47-150.
DR PDB; 4K7M; X-ray; 1.80 A; A=27-150.
DR PDB; 4L55; X-ray; 1.65 A; A/B=27-150.
DR PDB; 4MXF; X-ray; 2.25 A; A/B=27-150.
DR PDB; 4O36; X-ray; 1.22 A; A=27-41, B=47-150.
DR PDB; 4O37; X-ray; 1.40 A; A=27-41, B=47-150.
DR PDB; 4OKF; X-ray; 1.54 A; A=27-41, B=47-150.
DR PDB; 4OOH; X-ray; 1.89 A; A=27-150.
DR PDB; 4OT4; X-ray; 1.85 A; A/B=27-150.
DR PDB; 4PEQ; X-ray; 2.21 A; A/C=27-150.
DR PDB; 4POU; X-ray; 1.75 A; A=27-150.
DR PDB; 4QH3; X-ray; 2.00 A; A/B=27-150.
DR PDB; 4RAT; X-ray; 1.50 A; A=27-150.
DR PDB; 4RSD; X-ray; 1.60 A; A=27-150.
DR PDB; 4RSK; X-ray; 2.10 A; A=27-150.
DR PDB; 4RTE; X-ray; 1.95 A; A=27-150.
DR PDB; 4S0Q; X-ray; 2.09 A; A/B=27-150.
DR PDB; 4S18; X-ray; 2.27 A; A/B=27-150.
DR PDB; 4SRN; X-ray; 2.00 A; A=27-139, B=140-150.
DR PDB; 4WYN; X-ray; 1.80 A; A/B=27-150.
DR PDB; 4WYP; X-ray; 1.50 A; A/B=27-150.
DR PDB; 4WYZ; X-ray; 1.45 A; A/B=27-150.
DR PDB; 4YGW; X-ray; 2.18 A; B=48-150, b=27-41.
DR PDB; 4ZZ4; Neutron; 1.80 A; A=27-150.
DR PDB; 5D6U; X-ray; 1.52 A; A=27-150.
DR PDB; 5D97; Neutron; 1.80 A; A=27-150.
DR PDB; 5E5E; X-ray; 1.98 A; A/B=27-150.
DR PDB; 5E5F; X-ray; 1.68 A; A/B=27-150.
DR PDB; 5ET4; X-ray; 2.10 A; A/B/C/D=27-150.
DR PDB; 5JLG; X-ray; 1.79 A; A/B=27-150.
DR PDB; 5JMG; X-ray; 1.85 A; A/B=27-150.
DR PDB; 5JML; X-ray; 2.29 A; A/B=27-150.
DR PDB; 5NA9; X-ray; 2.07 A; A=27-150.
DR PDB; 5NJ7; X-ray; 2.15 A; A/B=27-150.
DR PDB; 5OBC; X-ray; 2.07 A; A/B=27-150.
DR PDB; 5OBD; X-ray; 1.98 A; A/B=27-150.
DR PDB; 5OBE; X-ray; 1.82 A; A/B=27-150.
DR PDB; 5OGH; X-ray; 1.16 A; A=27-150.
DR PDB; 5OLD; X-ray; 1.78 A; A/B=27-150.
DR PDB; 5RAT; X-ray; 1.50 A; A=27-150.
DR PDB; 5RSA; X-ray; 2.00 A; A=27-150.
DR PDB; 6ETK; X-ray; 0.85 A; A=27-150.
DR PDB; 6ETL; X-ray; 0.85 A; A=27-150.
DR PDB; 6ETM; X-ray; 0.92 A; A=27-150.
DR PDB; 6ETN; X-ray; 0.92 A; A=27-150.
DR PDB; 6ETO; X-ray; 1.02 A; A=27-150.
DR PDB; 6ETP; X-ray; 1.02 A; A=27-150.
DR PDB; 6ETQ; X-ray; 1.08 A; A=27-150.
DR PDB; 6ETR; X-ray; 1.17 A; A=27-150.
DR PDB; 6F60; X-ray; 1.14 A; A/B=27-150.
DR PDB; 6GOK; X-ray; 2.65 A; A/B=27-150.
DR PDB; 6PVU; X-ray; 1.49 A; A/B=27-150.
DR PDB; 6PVV; X-ray; 1.65 A; A/B=27-150.
DR PDB; 6PVW; X-ray; 1.60 A; A/B=27-150.
DR PDB; 6PVX; X-ray; 1.55 A; A/B=27-150.
DR PDB; 6QE9; X-ray; 2.03 A; A/B=27-150.
DR PDB; 6RAT; X-ray; 1.50 A; A=27-150.
DR PDB; 6RSA; X-ray; 2.00 A; A=27-150.
DR PDB; 6XHC; X-ray; 1.60 A; A/B=27-150.
DR PDB; 6XHD; X-ray; 1.51 A; A/B=27-150.
DR PDB; 6XHE; X-ray; 1.88 A; A/B=27-150.
DR PDB; 6XHF; X-ray; 1.45 A; A/B=27-150.
DR PDB; 6XVX; X-ray; 1.40 A; AAA/BBB=27-150.
DR PDB; 6XW0; X-ray; 1.80 A; AAA/BBB=27-150.
DR PDB; 6YO1; X-ray; 1.90 A; A/B=27-150.
DR PDB; 7P8R; X-ray; 1.27 A; A/B=27-150.
DR PDB; 7PNI; X-ray; 2.13 A; AAA/BBB=27-150.
DR PDB; 7QPW; X-ray; 1.15 A; AAA/BBB=27-150.
DR PDB; 7QPY; X-ray; 1.42 A; A/B=27-150.
DR PDB; 7QPZ; X-ray; 1.45 A; A/B=27-150.
DR PDB; 7RAT; X-ray; 1.50 A; A=27-150.
DR PDB; 7RSA; X-ray; 1.26 A; A=27-150.
DR PDB; 8RAT; X-ray; 1.50 A; A=27-150.
DR PDB; 8RSA; X-ray; 1.80 A; A/B=27-150.
DR PDB; 9RAT; X-ray; 1.50 A; A=27-150.
DR PDB; 9RSA; X-ray; 1.80 A; A/B=27-150.
DR PDBsum; 1A2W; -.
DR PDBsum; 1A5P; -.
DR PDBsum; 1A5Q; -.
DR PDBsum; 1AFK; -.
DR PDBsum; 1AFL; -.
DR PDBsum; 1AFU; -.
DR PDBsum; 1AQP; -.
DR PDBsum; 1B6V; -.
DR PDBsum; 1BEL; -.
DR PDBsum; 1BZQ; -.
DR PDBsum; 1C0B; -.
DR PDBsum; 1C0C; -.
DR PDBsum; 1C8W; -.
DR PDBsum; 1C9V; -.
DR PDBsum; 1C9X; -.
DR PDBsum; 1CJQ; -.
DR PDBsum; 1CJR; -.
DR PDBsum; 1D5D; -.
DR PDBsum; 1D5E; -.
DR PDBsum; 1D5H; -.
DR PDBsum; 1DFJ; -.
DR PDBsum; 1DY5; -.
DR PDBsum; 1EIC; -.
DR PDBsum; 1EID; -.
DR PDBsum; 1EIE; -.
DR PDBsum; 1EOS; -.
DR PDBsum; 1EOW; -.
DR PDBsum; 1F0V; -.
DR PDBsum; 1FEV; -.
DR PDBsum; 1FS3; -.
DR PDBsum; 1GV7; -.
DR PDBsum; 1IZP; -.
DR PDBsum; 1IZQ; -.
DR PDBsum; 1IZR; -.
DR PDBsum; 1J7Z; -.
DR PDBsum; 1J80; -.
DR PDBsum; 1J81; -.
DR PDBsum; 1J82; -.
DR PDBsum; 1JN4; -.
DR PDBsum; 1JS0; -.
DR PDBsum; 1JVT; -.
DR PDBsum; 1JVU; -.
DR PDBsum; 1JVV; -.
DR PDBsum; 1KF2; -.
DR PDBsum; 1KF3; -.
DR PDBsum; 1KF4; -.
DR PDBsum; 1KF5; -.
DR PDBsum; 1KF7; -.
DR PDBsum; 1KF8; -.
DR PDBsum; 1KH8; -.
DR PDBsum; 1LSQ; -.
DR PDBsum; 1O0F; -.
DR PDBsum; 1O0H; -.
DR PDBsum; 1O0M; -.
DR PDBsum; 1O0N; -.
DR PDBsum; 1O0O; -.
DR PDBsum; 1QHC; -.
DR PDBsum; 1RAR; -.
DR PDBsum; 1RAS; -.
DR PDBsum; 1RAT; -.
DR PDBsum; 1RBB; -.
DR PDBsum; 1RBC; -.
DR PDBsum; 1RBD; -.
DR PDBsum; 1RBE; -.
DR PDBsum; 1RBF; -.
DR PDBsum; 1RBG; -.
DR PDBsum; 1RBH; -.
DR PDBsum; 1RBI; -.
DR PDBsum; 1RBJ; -.
DR PDBsum; 1RBN; -.
DR PDBsum; 1RBW; -.
DR PDBsum; 1RBX; -.
DR PDBsum; 1RCA; -.
DR PDBsum; 1RCN; -.
DR PDBsum; 1RHA; -.
DR PDBsum; 1RHB; -.
DR PDBsum; 1RNC; -.
DR PDBsum; 1RND; -.
DR PDBsum; 1RNM; -.
DR PDBsum; 1RNN; -.
DR PDBsum; 1RNO; -.
DR PDBsum; 1RNQ; -.
DR PDBsum; 1RNU; -.
DR PDBsum; 1RNV; -.
DR PDBsum; 1RNW; -.
DR PDBsum; 1RNX; -.
DR PDBsum; 1RNY; -.
DR PDBsum; 1RNZ; -.
DR PDBsum; 1ROB; -.
DR PDBsum; 1RPF; -.
DR PDBsum; 1RPG; -.
DR PDBsum; 1RPH; -.
DR PDBsum; 1RSM; -.
DR PDBsum; 1RTA; -.
DR PDBsum; 1RTB; -.
DR PDBsum; 1RUV; -.
DR PDBsum; 1SRN; -.
DR PDBsum; 1SSA; -.
DR PDBsum; 1SSB; -.
DR PDBsum; 1SSC; -.
DR PDBsum; 1U1B; -.
DR PDBsum; 1UN5; -.
DR PDBsum; 1W4O; -.
DR PDBsum; 1W4P; -.
DR PDBsum; 1W4Q; -.
DR PDBsum; 1WBU; -.
DR PDBsum; 1XPS; -.
DR PDBsum; 1XPT; -.
DR PDBsum; 1YMN; -.
DR PDBsum; 1YMR; -.
DR PDBsum; 1YMW; -.
DR PDBsum; 1Z3L; -.
DR PDBsum; 1Z3M; -.
DR PDBsum; 1Z3P; -.
DR PDBsum; 1Z6D; -.
DR PDBsum; 1Z6S; -.
DR PDBsum; 2AAS; -.
DR PDBsum; 2APQ; -.
DR PDBsum; 2BLP; -.
DR PDBsum; 2BLZ; -.
DR PDBsum; 2E33; -.
DR PDBsum; 2E3W; -.
DR PDBsum; 2G4W; -.
DR PDBsum; 2G4X; -.
DR PDBsum; 2G8Q; -.
DR PDBsum; 2G8R; -.
DR PDBsum; 2NUI; -.
DR PDBsum; 2OP2; -.
DR PDBsum; 2OQF; -.
DR PDBsum; 2P42; -.
DR PDBsum; 2P43; -.
DR PDBsum; 2P44; -.
DR PDBsum; 2P45; -.
DR PDBsum; 2P46; -.
DR PDBsum; 2P47; -.
DR PDBsum; 2P48; -.
DR PDBsum; 2P49; -.
DR PDBsum; 2P4A; -.
DR PDBsum; 2QCA; -.
DR PDBsum; 2RAT; -.
DR PDBsum; 2RLN; -.
DR PDBsum; 2RNS; -.
DR PDBsum; 2W5G; -.
DR PDBsum; 2W5I; -.
DR PDBsum; 2W5K; -.
DR PDBsum; 2W5L; -.
DR PDBsum; 2W5M; -.
DR PDBsum; 2XOG; -.
DR PDBsum; 2XOI; -.
DR PDBsum; 3A1R; -.
DR PDBsum; 3D6O; -.
DR PDBsum; 3D6P; -.
DR PDBsum; 3D6Q; -.
DR PDBsum; 3D7B; -.
DR PDBsum; 3D8Y; -.
DR PDBsum; 3D8Z; -.
DR PDBsum; 3DH5; -.
DR PDBsum; 3DH6; -.
DR PDBsum; 3DI7; -.
DR PDBsum; 3DI8; -.
DR PDBsum; 3DI9; -.
DR PDBsum; 3DIB; -.
DR PDBsum; 3DIC; -.
DR PDBsum; 3DXG; -.
DR PDBsum; 3DXH; -.
DR PDBsum; 3EUX; -.
DR PDBsum; 3EUY; -.
DR PDBsum; 3EUZ; -.
DR PDBsum; 3EV0; -.
DR PDBsum; 3EV1; -.
DR PDBsum; 3EV2; -.
DR PDBsum; 3EV3; -.
DR PDBsum; 3EV4; -.
DR PDBsum; 3EV5; -.
DR PDBsum; 3EV6; -.
DR PDBsum; 3FKZ; -.
DR PDBsum; 3FL0; -.
DR PDBsum; 3FL1; -.
DR PDBsum; 3FL3; -.
DR PDBsum; 3I67; -.
DR PDBsum; 3I6F; -.
DR PDBsum; 3I6H; -.
DR PDBsum; 3I6J; -.
DR PDBsum; 3I7W; -.
DR PDBsum; 3I7X; -.
DR PDBsum; 3I7Y; -.
DR PDBsum; 3JW1; -.
DR PDBsum; 3LXO; -.
DR PDBsum; 3MWQ; -.
DR PDBsum; 3MWR; -.
DR PDBsum; 3MX8; -.
DR PDBsum; 3MZQ; -.
DR PDBsum; 3MZR; -.
DR PDBsum; 3OQY; -.
DR PDBsum; 3OQZ; -.
DR PDBsum; 3OR0; -.
DR PDBsum; 3QL1; -.
DR PDBsum; 3QL2; -.
DR PDBsum; 3QSK; -.
DR PDBsum; 3RAT; -.
DR PDBsum; 3RH1; -.
DR PDBsum; 3RID; -.
DR PDBsum; 3RN3; -.
DR PDBsum; 3RSD; -.
DR PDBsum; 3RSK; -.
DR PDBsum; 3RSP; -.
DR PDBsum; 3SRN; -.
DR PDBsum; 4AO1; -.
DR PDBsum; 4G8V; -.
DR PDBsum; 4G8Y; -.
DR PDBsum; 4G90; -.
DR PDBsum; 4J5Z; -.
DR PDBsum; 4J60; -.
DR PDBsum; 4J61; -.
DR PDBsum; 4J62; -.
DR PDBsum; 4J63; -.
DR PDBsum; 4J64; -.
DR PDBsum; 4J65; -.
DR PDBsum; 4J66; -.
DR PDBsum; 4J67; -.
DR PDBsum; 4J68; -.
DR PDBsum; 4J69; -.
DR PDBsum; 4J6A; -.
DR PDBsum; 4K7L; -.
DR PDBsum; 4K7M; -.
DR PDBsum; 4L55; -.
DR PDBsum; 4MXF; -.
DR PDBsum; 4O36; -.
DR PDBsum; 4O37; -.
DR PDBsum; 4OKF; -.
DR PDBsum; 4OOH; -.
DR PDBsum; 4OT4; -.
DR PDBsum; 4PEQ; -.
DR PDBsum; 4POU; -.
DR PDBsum; 4QH3; -.
DR PDBsum; 4RAT; -.
DR PDBsum; 4RSD; -.
DR PDBsum; 4RSK; -.
DR PDBsum; 4RTE; -.
DR PDBsum; 4S0Q; -.
DR PDBsum; 4S18; -.
DR PDBsum; 4SRN; -.
DR PDBsum; 4WYN; -.
DR PDBsum; 4WYP; -.
DR PDBsum; 4WYZ; -.
DR PDBsum; 4YGW; -.
DR PDBsum; 4ZZ4; -.
DR PDBsum; 5D6U; -.
DR PDBsum; 5D97; -.
DR PDBsum; 5E5E; -.
DR PDBsum; 5E5F; -.
DR PDBsum; 5ET4; -.
DR PDBsum; 5JLG; -.
DR PDBsum; 5JMG; -.
DR PDBsum; 5JML; -.
DR PDBsum; 5NA9; -.
DR PDBsum; 5NJ7; -.
DR PDBsum; 5OBC; -.
DR PDBsum; 5OBD; -.
DR PDBsum; 5OBE; -.
DR PDBsum; 5OGH; -.
DR PDBsum; 5OLD; -.
DR PDBsum; 5RAT; -.
DR PDBsum; 5RSA; -.
DR PDBsum; 6ETK; -.
DR PDBsum; 6ETL; -.
DR PDBsum; 6ETM; -.
DR PDBsum; 6ETN; -.
DR PDBsum; 6ETO; -.
DR PDBsum; 6ETP; -.
DR PDBsum; 6ETQ; -.
DR PDBsum; 6ETR; -.
DR PDBsum; 6F60; -.
DR PDBsum; 6GOK; -.
DR PDBsum; 6PVU; -.
DR PDBsum; 6PVV; -.
DR PDBsum; 6PVW; -.
DR PDBsum; 6PVX; -.
DR PDBsum; 6QE9; -.
DR PDBsum; 6RAT; -.
DR PDBsum; 6RSA; -.
DR PDBsum; 6XHC; -.
DR PDBsum; 6XHD; -.
DR PDBsum; 6XHE; -.
DR PDBsum; 6XHF; -.
DR PDBsum; 6XVX; -.
DR PDBsum; 6XW0; -.
DR PDBsum; 6YO1; -.
DR PDBsum; 7P8R; -.
DR PDBsum; 7PNI; -.
DR PDBsum; 7QPW; -.
DR PDBsum; 7QPY; -.
DR PDBsum; 7QPZ; -.
DR PDBsum; 7RAT; -.
DR PDBsum; 7RSA; -.
DR PDBsum; 8RAT; -.
DR PDBsum; 8RSA; -.
DR PDBsum; 9RAT; -.
DR PDBsum; 9RSA; -.
DR AlphaFoldDB; P61823; -.
DR BMRB; P61823; -.
DR PCDDB; P61823; -.
DR SASBDB; P61823; -.
DR SMR; P61823; -.
DR BioGRID; 159601; 1.
DR DIP; DIP-36384N; -.
DR IntAct; P61823; 7.
DR MINT; P61823; -.
DR STRING; 9913.ENSBTAP00000011586; -.
DR BindingDB; P61823; -.
DR ChEMBL; CHEMBL6091; -.
DR DrugCentral; P61823; -.
DR CarbonylDB; P61823; -.
DR GlyConnect; 529; 21 N-Linked glycans (1 site).
DR PaxDb; P61823; -.
DR PeptideAtlas; P61823; -.
DR PRIDE; P61823; -.
DR ABCD; P61823; 5 sequenced antibodies.
DR Ensembl; ENSBTAT00000011586; ENSBTAP00000011586; ENSBTAG00000008793.
DR GeneID; 282340; -.
DR KEGG; bta:282340; -.
DR CTD; 6035; -.
DR VEuPathDB; HostDB:ENSBTAG00000008793; -.
DR eggNOG; ENOG502SQ4K; Eukaryota.
DR GeneTree; ENSGT00940000160869; -.
DR HOGENOM; CLU_117006_0_0_1; -.
DR InParanoid; P61823; -.
DR OMA; MRFQRQH; -.
DR OrthoDB; 1549558at2759; -.
DR TreeFam; TF333393; -.
DR BRENDA; 4.6.1.18; 908.
DR SABIO-RK; P61823; -.
DR EvolutionaryTrace; P61823; -.
DR PRO; PR:P61823; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000008793; Expressed in corpus epididymis and 92 other tissues.
DR ExpressionAtlas; P61823; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004522; F:ribonuclease A activity; IEA:UniProtKB-EC.
DR GO; GO:0004540; F:ribonuclease activity; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0090501; P:RNA phosphodiester bond hydrolysis; IBA:GO_Central.
DR Gene3D; 3.10.130.10; -; 1.
DR InterPro; IPR001427; RNaseA.
DR InterPro; IPR036816; RNaseA-like_dom_sf.
DR InterPro; IPR023411; RNaseA_AS.
DR InterPro; IPR023412; RNaseA_domain.
DR PANTHER; PTHR11437; PTHR11437; 1.
DR Pfam; PF00074; RnaseA; 1.
DR PRINTS; PR00794; RIBONUCLEASE.
DR SMART; SM00092; RNAse_Pc; 1.
DR SUPFAM; SSF54076; SSF54076; 1.
DR PROSITE; PS00127; RNASE_PANCREATIC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Disulfide bond; Endonuclease;
KW Glycation; Glycoprotein; Hydrolase; Lyase; Nuclease; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000269|PubMed:13989651,
FT ECO:0000269|PubMed:14235531"
FT CHAIN 27..150
FT /note="Ribonuclease pancreatic"
FT /id="PRO_0000030915"
FT ACT_SITE 38
FT /note="Proton acceptor"
FT ACT_SITE 145
FT /note="Proton donor"
FT BINDING 33
FT /ligand="substrate"
FT BINDING 36
FT /ligand="substrate"
FT BINDING 67..71
FT /ligand="substrate"
FT BINDING 92
FT /ligand="substrate"
FT BINDING 111
FT /ligand="substrate"
FT CARBOHYD 27
FT /note="N-linked (Glc) (glycation) lysine; in vitro"
FT /evidence="ECO:0000269|PubMed:4030761"
FT CARBOHYD 33
FT /note="N-linked (Glc) (glycation) lysine; in vitro"
FT /evidence="ECO:0000269|PubMed:4030761"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine; partial"
FT /evidence="ECO:0000269|PubMed:19358553"
FT /id="CAR_000006"
FT CARBOHYD 63
FT /note="N-linked (Glc) (glycation) lysine; in vitro"
FT /evidence="ECO:0000269|PubMed:4030761"
FT CARBOHYD 67
FT /note="N-linked (Glc) (glycation) lysine; in vitro"
FT /evidence="ECO:0000269|PubMed:4030761"
FT DISULFID 52..110
FT /evidence="ECO:0000269|PubMed:13989651"
FT DISULFID 66..121
FT /evidence="ECO:0000269|PubMed:13989651"
FT DISULFID 84..136
FT /evidence="ECO:0000269|PubMed:13989651"
FT DISULFID 91..98
FT /evidence="ECO:0000269|PubMed:13989651"
FT MUTAGEN 38
FT /note="H->A: Loss of activity."
FT MUTAGEN 145
FT /note="H->A: Loss of activity."
FT HELIX 30..38
FT /evidence="ECO:0007829|PDB:6ETK"
FT STRAND 43..45
FT /evidence="ECO:0007829|PDB:1DY5"
FT HELIX 48..50
FT /evidence="ECO:0007829|PDB:3FL0"
FT HELIX 51..58
FT /evidence="ECO:0007829|PDB:6ETK"
FT TURN 59..62
FT /evidence="ECO:0007829|PDB:6ETK"
FT STRAND 63..65
FT /evidence="ECO:0007829|PDB:6ETK"
FT STRAND 68..73
FT /evidence="ECO:0007829|PDB:6ETK"
FT HELIX 77..81
FT /evidence="ECO:0007829|PDB:6ETK"
FT HELIX 82..85
FT /evidence="ECO:0007829|PDB:6ETK"
FT STRAND 86..89
FT /evidence="ECO:0007829|PDB:6ETK"
FT STRAND 92..94
FT /evidence="ECO:0007829|PDB:3DH6"
FT STRAND 98..100
FT /evidence="ECO:0007829|PDB:6ETK"
FT STRAND 105..112
FT /evidence="ECO:0007829|PDB:6ETK"
FT STRAND 118..120
FT /evidence="ECO:0007829|PDB:1YMN"
FT STRAND 123..130
FT /evidence="ECO:0007829|PDB:6ETK"
FT STRAND 132..137
FT /evidence="ECO:0007829|PDB:6ETK"
FT TURN 138..141
FT /evidence="ECO:0007829|PDB:6ETK"
FT STRAND 142..149
FT /evidence="ECO:0007829|PDB:6ETK"
SQ SEQUENCE 150 AA; 16461 MW; 74E5DC61E679187D CRC64;
MALKSLVLLS LLVLVLLLVR VQPSLGKETA AAKFERQHMD SSTSAASSSN YCNQMMKSRN
LTKDRCKPVN TFVHESLADV QAVCSQKNVA CKNGQTNCYQ SYSTMSITDC RETGSSKYPN
CAYKTTQANK HIIVACEGNP YVPVHFDASV
