ID   RNAS4_PONAB             Reviewed;         147 AA.
AC   Q5NVS4;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Ribonuclease 4;
DE            Short=RNase 4;
DE            EC=3.1.27.-;
DE   Flags: Precursor;
GN   Name=RNASE4;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This RNase has marked specificity towards the 3' side of
CC       uridine nucleotides. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000305}.
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DR   EMBL; CR925928; CAI29589.1; -; mRNA.
DR   RefSeq; NP_001127675.1; NM_001134203.2.
DR   RefSeq; XP_009247114.1; XM_009248839.1.
DR   AlphaFoldDB; Q5NVS4; -.
DR   SMR; Q5NVS4; -.
DR   STRING; 9601.ENSPPYP00000006341; -.
DR   Ensembl; ENSPPYT00000006595; ENSPPYP00000006341; ENSPPYG00000005573.
DR   GeneID; 100174757; -.
DR   KEGG; pon:100174757; -.
DR   CTD; 6038; -.
DR   eggNOG; ENOG502S9Q1; Eukaryota.
DR   GeneTree; ENSGT00940000157645; -.
DR   HOGENOM; CLU_117006_3_1_1; -.
DR   InParanoid; Q5NVS4; -.
DR   OMA; VPNCRYR; -.
DR   TreeFam; TF333393; -.
DR   Proteomes; UP000001595; Chromosome 14.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:Ensembl.
DR   Gene3D; 3.10.130.10; -; 1.
DR   InterPro; IPR001427; RNaseA.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
DR   InterPro; IPR023411; RNaseA_AS.
DR   InterPro; IPR023412; RNaseA_domain.
DR   PANTHER; PTHR11437; PTHR11437; 1.
DR   Pfam; PF00074; RnaseA; 1.
DR   PRINTS; PR00794; RIBONUCLEASE.
DR   SMART; SM00092; RNAse_Pc; 1.
DR   SUPFAM; SSF54076; SSF54076; 1.
DR   PROSITE; PS00127; RNASE_PANCREATIC; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Endonuclease; Hydrolase; Nuclease;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..147
FT                   /note="Ribonuclease 4"
FT                   /id="PRO_0000045837"
FT   ACT_SITE        40
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        144
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         38
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         68..72
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         93
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         110
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         29
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P15467"
FT   DISULFID        53..109
FT                   /evidence="ECO:0000250|UniProtKB:P34096"
FT   DISULFID        67..120
FT                   /evidence="ECO:0000250|UniProtKB:P34096"
FT   DISULFID        85..135
FT                   /evidence="ECO:0000250|UniProtKB:P34096"
FT   DISULFID        92..99
FT                   /evidence="ECO:0000250|UniProtKB:P34096"
SQ   SEQUENCE   147 AA;  16855 MW;  699DFDC11FD515A2 CRC64;
     MALQRTHSLL LLLLLTLLGL GLVQPSYGQD GMYQRFLRQH VHPEETGGND RYCNLMMQRR
     KMTLYHCKRF NTFIHEDIWN IRSICSTTNI QCKNGKTNCH EGVVKVTDCR DTGSSRAPNC
     RYRAMASTRR VVIACEGNPQ VPVHFDG