RNAS8_AOTTR
ID RNAS8_AOTTR Reviewed; 155 AA.
AC Q8SPZ5;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Ribonuclease 8;
DE Short=RNase 8;
DE EC=3.1.27.-;
DE Flags: Precursor;
GN Name=RNASE8;
OS Aotus trivirgatus (Three-striped night monkey) (Douroucouli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=9505;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11861908; DOI=10.1093/nar/30.5.1169;
RA Zhang J., Dyer K.D., Rosenberg H.F.;
RT "RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in
RT placenta.";
RL Nucleic Acids Res. 30:1169-1175(2002).
CC -!- FUNCTION: Has a low ribonuclease activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC {ECO:0000305}.
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DR EMBL; AF473860; AAL89649.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8SPZ5; -.
DR SMR; Q8SPZ5; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.10.130.10; -; 1.
DR InterPro; IPR001427; RNaseA.
DR InterPro; IPR036816; RNaseA-like_dom_sf.
DR InterPro; IPR023411; RNaseA_AS.
DR InterPro; IPR023412; RNaseA_domain.
DR PANTHER; PTHR11437; PTHR11437; 1.
DR Pfam; PF00074; RnaseA; 1.
DR PRINTS; PR00794; RIBONUCLEASE.
DR SMART; SM00092; RNAse_Pc; 1.
DR SUPFAM; SSF54076; SSF54076; 1.
DR PROSITE; PS00127; RNASE_PANCREATIC; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Endonuclease; Hydrolase; Nuclease; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..155
FT /note="Ribonuclease 8"
FT /id="PRO_0000030903"
FT ACT_SITE 43
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT ACT_SITE 150
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 66..70
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 91
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT DISULFID 65..119
FT /evidence="ECO:0000250"
FT DISULFID 83..134
FT /evidence="ECO:0000250"
FT DISULFID 90..97
FT /evidence="ECO:0000250"
SQ SEQUENCE 155 AA; 17250 MW; 5B403AF497A6A4A7 CRC64;
MAPAREGCCP LLLLLLLGLW VAEIPVSAKP EGMTSSQWFN TQHVQPSPQA CDSAMRDINK
HTKRCKDLNT FLHKPFSSVA ATCQTPNITC KNGHKNCHQS HRPVSLTMCG LTSGKYPNCR
YKEEHQNKSY VVACEPPQQG DPEHSLVPVH FDKVV