RNAS8_HUMAN
ID RNAS8_HUMAN Reviewed; 154 AA.
AC Q8TDE3; B2RPP6; B2RPP7;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Ribonuclease 8;
DE Short=RNase 8;
DE EC=3.1.27.-;
DE Flags: Precursor;
GN Name=RNASE8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RX PubMed=11861908; DOI=10.1093/nar/30.5.1169;
RA Zhang J., Dyer K.D., Rosenberg H.F.;
RT "RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in
RT placenta.";
RL Nucleic Acids Res. 30:1169-1175(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-10.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has a low ribonuclease activity.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed prominently in the placenta and is not
CC detected in any other tissues examined.
CC -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC {ECO:0000305}.
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DR EMBL; AF473854; AAL89644.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66417.1; -; Genomic_DNA.
DR EMBL; BC137537; AAI37538.1; -; mRNA.
DR EMBL; BC137538; AAI37539.1; -; mRNA.
DR CCDS; CCDS9567.1; -.
DR RefSeq; NP_612204.1; NM_138331.2.
DR AlphaFoldDB; Q8TDE3; -.
DR SMR; Q8TDE3; -.
DR STRING; 9606.ENSP00000311398; -.
DR iPTMnet; Q8TDE3; -.
DR PhosphoSitePlus; Q8TDE3; -.
DR BioMuta; RNASE8; -.
DR DMDM; 23822095; -.
DR MassIVE; Q8TDE3; -.
DR PaxDb; Q8TDE3; -.
DR PeptideAtlas; Q8TDE3; -.
DR PRIDE; Q8TDE3; -.
DR Antibodypedia; 49755; 72 antibodies from 13 providers.
DR DNASU; 122665; -.
DR Ensembl; ENST00000308227.2; ENSP00000311398.2; ENSG00000173431.2.
DR GeneID; 122665; -.
DR KEGG; hsa:122665; -.
DR MANE-Select; ENST00000308227.2; ENSP00000311398.2; NM_138331.2; NP_612204.1.
DR UCSC; uc010tlm.3; human.
DR CTD; 122665; -.
DR GeneCards; RNASE8; -.
DR HGNC; HGNC:19277; RNASE8.
DR HPA; ENSG00000173431; Tissue enriched (salivary).
DR MIM; 612485; gene.
DR neXtProt; NX_Q8TDE3; -.
DR OpenTargets; ENSG00000173431; -.
DR PharmGKB; PA134930162; -.
DR VEuPathDB; HostDB:ENSG00000173431; -.
DR eggNOG; ENOG502TDZ3; Eukaryota.
DR GeneTree; ENSGT00940000164606; -.
DR HOGENOM; CLU_117006_0_1_1; -.
DR InParanoid; Q8TDE3; -.
DR OMA; RAGCCPL; -.
DR OrthoDB; 1549558at2759; -.
DR PhylomeDB; Q8TDE3; -.
DR TreeFam; TF333393; -.
DR PathwayCommons; Q8TDE3; -.
DR Reactome; R-HSA-6803157; Antimicrobial peptides.
DR BioGRID-ORCS; 122665; 9 hits in 1057 CRISPR screens.
DR GenomeRNAi; 122665; -.
DR Pharos; Q8TDE3; Tbio.
DR PRO; PR:Q8TDE3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8TDE3; protein.
DR Bgee; ENSG00000173431; Expressed in tonsil and 12 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004522; F:ribonuclease A activity; IDA:UniProtKB.
DR GO; GO:0004540; F:ribonuclease activity; IBA:GO_Central.
DR GO; GO:0061760; P:antifungal innate immune response; IDA:UniProtKB.
DR GO; GO:0050832; P:defense response to fungus; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IMP:UniProtKB.
DR Gene3D; 3.10.130.10; -; 1.
DR InterPro; IPR001427; RNaseA.
DR InterPro; IPR036816; RNaseA-like_dom_sf.
DR InterPro; IPR023411; RNaseA_AS.
DR InterPro; IPR023412; RNaseA_domain.
DR PANTHER; PTHR11437; PTHR11437; 1.
DR Pfam; PF00074; RnaseA; 1.
DR PRINTS; PR00794; RIBONUCLEASE.
DR SMART; SM00092; RNAse_Pc; 1.
DR SUPFAM; SSF54076; SSF54076; 1.
DR PROSITE; PS00127; RNASE_PANCREATIC; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Endonuclease; Hydrolase; Nuclease; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..154
FT /note="Ribonuclease 8"
FT /id="PRO_0000030902"
FT ACT_SITE 42
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT ACT_SITE 149
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 65..69
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 90
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT DISULFID 50..93
FT /evidence="ECO:0000255"
FT DISULFID 64..118
FT /evidence="ECO:0000250"
FT DISULFID 82..133
FT /evidence="ECO:0000250"
FT DISULFID 89..96
FT /evidence="ECO:0000250"
FT VARIANT 10
FT /note="P -> S (in dbSNP:rs12437266)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_052194"
SQ SEQUENCE 154 AA; 17041 MW; 25E6AA09B869DC8F CRC64;
MAPARAGCCP LLLLLLGLWV AEVLVRAKPK DMTSSQWFKT QHVQPSPQAC NSAMSIINKY
TERCKDLNTF LHEPFSSVAI TCQTPNIACK NSCKNCHQSH GPMSLTMGEL TSGKYPNCRY
KEKHLNTPYI VACDPPQQGD PGYPLVPVHL DKVV
