RNAS8_PANTR
ID RNAS8_PANTR Reviewed; 157 AA.
AC Q8SPZ8;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Ribonuclease 8;
DE Short=RNase 8;
DE EC=3.1.27.-;
DE Flags: Precursor;
GN Name=RNASE8;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11861908; DOI=10.1093/nar/30.5.1169;
RA Zhang J., Dyer K.D., Rosenberg H.F.;
RT "RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in
RT placenta.";
RL Nucleic Acids Res. 30:1169-1175(2002).
CC -!- FUNCTION: Has a low ribonuclease activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC {ECO:0000305}.
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DR EMBL; AF473855; AAL89645.1; -; Genomic_DNA.
DR RefSeq; NP_001009156.1; NM_001009156.1.
DR AlphaFoldDB; Q8SPZ8; -.
DR SMR; Q8SPZ8; -.
DR STRING; 9598.ENSPTRP00000052805; -.
DR PaxDb; Q8SPZ8; -.
DR GeneID; 493984; -.
DR KEGG; ptr:493984; -.
DR CTD; 122665; -.
DR eggNOG; ENOG502TDZ3; Eukaryota.
DR InParanoid; Q8SPZ8; -.
DR OrthoDB; 1549558at2759; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004540; F:ribonuclease activity; IBA:GO_Central.
DR GO; GO:0050832; P:defense response to fungus; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 3.10.130.10; -; 1.
DR InterPro; IPR001427; RNaseA.
DR InterPro; IPR036816; RNaseA-like_dom_sf.
DR InterPro; IPR023411; RNaseA_AS.
DR InterPro; IPR023412; RNaseA_domain.
DR PANTHER; PTHR11437; PTHR11437; 1.
DR Pfam; PF00074; RnaseA; 1.
DR PRINTS; PR00794; RIBONUCLEASE.
DR SMART; SM00092; RNAse_Pc; 1.
DR SUPFAM; SSF54076; SSF54076; 1.
DR PROSITE; PS00127; RNASE_PANCREATIC; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Endonuclease; Hydrolase; Nuclease; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..157
FT /note="Ribonuclease 8"
FT /id="PRO_0000030906"
FT ACT_SITE 45
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT ACT_SITE 152
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 68..72
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 93
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT DISULFID 53..96
FT /evidence="ECO:0000255"
FT DISULFID 67..121
FT /evidence="ECO:0000250"
FT DISULFID 85..136
FT /evidence="ECO:0000250"
FT DISULFID 92..99
FT /evidence="ECO:0000250"
SQ SEQUENCE 157 AA; 17282 MW; 604104B57FCACBA9 CRC64;
MAPARAGCCP LLLLLLLLLG LWVAEVLVSA KPKDMTSSQW FKTQHVQPGP QACNSAISNI
NKYTERCKDL NTFLHEPFSS VAITCQTPNI ACKNSCKNCH QSHGPMSLTM GELTSGKYPN
CRYKEKHLNT PYMVACDPPQ QGDPGYPLVP VHLDKVV