RNAS9_MOUSE
ID RNAS9_MOUSE Reviewed; 184 AA.
AC P60154;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Inactive ribonuclease-like protein 9;
DE Flags: Precursor;
GN Name=Rnase9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=FVB/N; TISSUE=Epididymis;
RX PubMed=12920233; DOI=10.1210/me.2003-0008;
RA Penttinen J., Pujianto D.A., Sipilae P., Huhtaniemi I., Poutanen M.;
RT "Discovery in silico and characterization in vitro of novel genes
RT exclusively expressed in the mouse epididymis.";
RL Mol. Endocrinol. 17:2138-2151(2003).
CC -!- FUNCTION: Does not exhibit any ribonuclease activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC {ECO:0000305}.
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DR EMBL; AY226989; AAP43946.1; -; mRNA.
DR CCDS; CCDS36909.1; -.
DR RefSeq; NP_898853.2; NM_183032.2.
DR RefSeq; XP_006519205.1; XM_006519142.3.
DR AlphaFoldDB; P60154; -.
DR SMR; P60154; -.
DR STRING; 10090.ENSMUSP00000066637; -.
DR GlyGen; P60154; 2 sites.
DR iPTMnet; P60154; -.
DR PhosphoSitePlus; P60154; -.
DR PaxDb; P60154; -.
DR PRIDE; P60154; -.
DR ProteomicsDB; 299924; -.
DR Antibodypedia; 175; 120 antibodies from 17 providers.
DR Ensembl; ENSMUST00000064214; ENSMUSP00000066637; ENSMUSG00000052382.
DR GeneID; 328401; -.
DR KEGG; mmu:328401; -.
DR UCSC; uc007tmh.1; mouse.
DR CTD; 390443; -.
DR MGI; MGI:3057273; Rnase9.
DR VEuPathDB; HostDB:ENSMUSG00000052382; -.
DR eggNOG; ENOG502TDU6; Eukaryota.
DR GeneTree; ENSGT00390000013952; -.
DR HOGENOM; CLU_1464451_0_0_1; -.
DR InParanoid; P60154; -.
DR OMA; LITCRWQ; -.
DR OrthoDB; 1271649at2759; -.
DR PhylomeDB; P60154; -.
DR TreeFam; TF338401; -.
DR BioGRID-ORCS; 328401; 1 hit in 70 CRISPR screens.
DR PRO; PR:P60154; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; P60154; protein.
DR Bgee; ENSMUSG00000052382; Expressed in testis.
DR ExpressionAtlas; P60154; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0060474; P:positive regulation of flagellated sperm motility involved in capacitation; IMP:MGI.
DR Gene3D; 3.10.130.10; -; 1.
DR InterPro; IPR029741; RNASE9.
DR InterPro; IPR001427; RNaseA.
DR InterPro; IPR036816; RNaseA-like_dom_sf.
DR InterPro; IPR023412; RNaseA_domain.
DR PANTHER; PTHR11437; PTHR11437; 1.
DR PANTHER; PTHR11437:SF14; PTHR11437:SF14; 1.
DR Pfam; PF00074; RnaseA; 1.
DR SUPFAM; SSF54076; SSF54076; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..184
FT /note="Inactive ribonuclease-like protein 9"
FT /id="PRO_0000030956"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 93..148
FT /evidence="ECO:0000250"
FT DISULFID 111..163
FT /evidence="ECO:0000250"
FT DISULFID 118..125
FT /evidence="ECO:0000250"
SQ SEQUENCE 184 AA; 21378 MW; 89B3A112C06066C3 CRC64;
MKPLVIKFAW PLPLLLLLLL PPKLQGNYWD FGEYELNPEV RDFIREYEST GPTKPPTVKR
IIEMITIGDQ PFNDYDYCNT ELRTKQIHYK GRCYPEHYIA GVPYGELVKA CDGEEVQCKN
GVKSCRRSMN LIEGVRCVLE TGQQMTNCTY KTILMIGYPV VSCQWDEETK IFIPDHIYNM
SLPK
