ID   RNAS_ARTBC              Reviewed;         160 AA.
AC   D4AS55;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Ribonuclease ARB_07070 {ECO:0000305};
DE            EC=3.1.27.- {ECO:0000250|UniProtKB:P00655};
DE   AltName: Full=Major allergen Asp f 1 homolog {ECO:0000305};
DE   Flags: Precursor;
GN   ORFNames=ARB_07070;
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000312|Proteomes:UP000008866};
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
CC   -!- FUNCTION: This purine-specific ribonuclease cleaves 28S RNA in
CC       eukaryotic ribosomes, inhibits protein synthesis, and shows antitumor
CC       activity. {ECO:0000250|UniProtKB:P67875}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P67875}.
CC   -!- ALLERGEN: May cause an allergic reaction in human. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ribonuclease U2 family. {ECO:0000305}.
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DR   EMBL; ABSU01000007; EFE34119.1; -; Genomic_DNA.
DR   RefSeq; XP_003014508.1; XM_003014462.1.
DR   AlphaFoldDB; D4AS55; -.
DR   SMR; D4AS55; -.
DR   STRING; 63400.XP_003014508.1; -.
DR   EnsemblFungi; EFE34119; EFE34119; ARB_07070.
DR   GeneID; 9520560; -.
DR   KEGG; abe:ARB_07070; -.
DR   eggNOG; ENOG502SV0S; Eukaryota.
DR   HOGENOM; CLU_106852_0_0_1; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   InterPro; IPR000026; Gua-sp_ribonuclease_N1/T1/U2.
DR   InterPro; IPR016191; Ribonuclease/ribotoxin.
DR   PIRSF; PIRSF037430; RNase_U2; 1.
DR   SUPFAM; SSF53933; SSF53933; 1.
PE   3: Inferred from homology;
KW   Allergen; Hydrolase; Nuclease; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..160
FT                   /note="Ribonuclease ARB_07070"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000434428"
FT   REGION          26..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        103
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P00655"
FT   ACT_SITE        144
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:P00655"
SQ   SEQUENCE   160 AA;  17486 MW;  3296A9108CD14C6B CRC64;
     MVSFKAILTL SLIGAAFATP IEQRAAEPVE DSGAVANSPE GSGMDLGGTD PTADAIEERG
     LLVRNILRQL LNNKQSGLTI ISSTSNAITW LSRPPRRGRS LREYPVFQQH HKVYNYNSRP
     KENPGPFRLI ATKDSRHFCG IISHDGIGHN PNAGLFHLCK