RNB3L_MOUSE
ID RNB3L_MOUSE Reviewed; 491 AA.
AC Q6PDH4; Q3V1J9;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Ran-binding protein 3-like;
GN Name=Ranbp3l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP INTERACTION WITH SMAD1, AND SUBCELLULAR LOCATION.
RX PubMed=25755279; DOI=10.1128/mcb.00121-15;
RA Chen F., Lin X., Xu P., Zhang Z., Chen Y., Wang C., Han J., Zhao B.,
RA Xiao M., Feng X.H.;
RT "Nuclear export of Smads by RanBP3L regulates bone morphogenetic protein
RT signaling and mesenchymal stem cell differentiation.";
RL Mol. Cell. Biol. 35:1700-1711(2015).
CC -!- FUNCTION: Nuclear export factor for BMP-specific SMAD1/5/8 that plays a
CC critical role in terminating BMP signaling and regulating mesenchymal
CC stem cell differentiation by blocking osteoblast differentiation to
CC promote myogenic differention. Directly recognizes dephosphorylated
CC SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner.
CC {ECO:0000250|UniProtKB:Q86VV4, ECO:0000269|PubMed:25755279}.
CC -!- SUBUNIT: Interacts with SMAD1, SMAD5 and SMAD8.
CC {ECO:0000250|UniProtKB:Q86VV4, ECO:0000269|PubMed:25755279}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:25755279}. Cytoplasm
CC {ECO:0000305|PubMed:25755279}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PDH4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PDH4-2; Sequence=VSP_029895, VSP_029896;
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DR EMBL; AK132406; BAE21151.1; -; mRNA.
DR EMBL; BC058706; AAH58706.1; -; mRNA.
DR RefSeq; NP_932141.1; NM_198024.2. [Q6PDH4-1]
DR AlphaFoldDB; Q6PDH4; -.
DR SMR; Q6PDH4; -.
DR STRING; 10090.ENSMUSP00000055750; -.
DR iPTMnet; Q6PDH4; -.
DR PhosphoSitePlus; Q6PDH4; -.
DR PaxDb; Q6PDH4; -.
DR PRIDE; Q6PDH4; -.
DR ProteomicsDB; 260986; -. [Q6PDH4-1]
DR ProteomicsDB; 260987; -. [Q6PDH4-2]
DR Antibodypedia; 43549; 101 antibodies from 19 providers.
DR DNASU; 223332; -.
DR Ensembl; ENSMUST00000227191; ENSMUSP00000154327; ENSMUSG00000048424. [Q6PDH4-1]
DR GeneID; 223332; -.
DR KEGG; mmu:223332; -.
DR UCSC; uc033gsz.1; mouse. [Q6PDH4-1]
DR CTD; 202151; -.
DR MGI; MGI:2444654; Ranbp3l.
DR eggNOG; KOG0866; Eukaryota.
DR GeneTree; ENSGT00940000161387; -.
DR HOGENOM; CLU_2385570_0_0_1; -.
DR InParanoid; Q6PDH4; -.
DR OMA; NSTEQGP; -.
DR OrthoDB; 918488at2759; -.
DR PhylomeDB; Q6PDH4; -.
DR BioGRID-ORCS; 223332; 0 hits in 51 CRISPR screens.
DR ChiTaRS; Ranbp3l; mouse.
DR PRO; PR:Q6PDH4; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q6PDH4; protein.
DR Bgee; ENSMUSG00000048424; Expressed in right kidney and 35 other tissues.
DR ExpressionAtlas; Q6PDH4; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0046332; F:SMAD binding; IPI:UniProtKB.
DR GO; GO:1901706; P:mesenchymal cell differentiation involved in bone development; IMP:UniProtKB.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IMP:UniProtKB.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; IMP:UniProtKB.
DR GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR PANTHER; PTHR23138; PTHR23138; 1.
DR Pfam; PF00638; Ran_BP1; 1.
DR SMART; SM00160; RanBD; 1.
DR PROSITE; PS50196; RANBD1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..491
FT /note="Ran-binding protein 3-like"
FT /id="PRO_0000312750"
FT DOMAIN 270..441
FT /note="RanBD1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT REGION 440..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 90..446
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029895"
FT VAR_SEQ 452..491
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029896"
SQ SEQUENCE 491 AA; 54492 MW; 45800019513621C5 CRC64;
MSTTQRKDDS HLFTSSCTRQ LQVQEDRQQQ EKYVIAQPIF VFEKGEHNFK RPAEDSLEET
AEPEFTGFLR KRVRSSSVTL HTTDPQSQGV ATLSQTRLRS SSFTDVPTFP PCRPVRKNNV
FMTSRLLQRS DDMNNVEQGP PMRSSEQVLR PAVLQPSQTQ SCQKAGTTFG PGALKSYKTK
EKAEHEISEV GSSSSLLSEN LPNARSSIQL STDPCISEAP SGCQPKEDKC SFTSCSSDFV
FGENMVERVL GTQKLTQPPL QNLSYAKEKT FKSVLKFPNA VSNSDSIENI SLVESAAAFS
SKPSQKCLLE KIDVITGEET EHNVLKINCK IFVFNKATES WSERGQGILR LNDTAGRECG
TLQSRLIMRN QGSLRLVLNS RLWAQMKIQR ASQKNLRITA TDLEDDGIKI FLIQASAKDT
GFLYAAIHHR LVALRSLAKQ GDGGPAESQS DTALPQLNGE SCDEDEDEIA QVTKNGSDPS
RWSHRQSIVC S
