ID   RNBP6_MOUSE             Reviewed;        1105 AA.
AC   Q8BIV3; Q3TTJ6;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Ran-binding protein 6;
DE            Short=RanBP6;
GN   Name=Ranbp6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 667-1105.
RC   STRAIN=C57BL/6J; TISSUE=Hippocampus, and Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May function in nuclear protein import as nuclear transport
CC       receptor.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC38756.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAE36329.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AC120159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK083089; BAC38756.1; ALT_INIT; mRNA.
DR   EMBL; AK161331; BAE36329.1; ALT_INIT; mRNA.
DR   CCDS; CCDS37954.1; -.
DR   RefSeq; NP_808389.2; NM_177721.4.
DR   AlphaFoldDB; Q8BIV3; -.
DR   SMR; Q8BIV3; -.
DR   BioGRID; 232214; 9.
DR   STRING; 10090.ENSMUSP00000100503; -.
DR   iPTMnet; Q8BIV3; -.
DR   PhosphoSitePlus; Q8BIV3; -.
DR   MaxQB; Q8BIV3; -.
DR   PaxDb; Q8BIV3; -.
DR   PRIDE; Q8BIV3; -.
DR   ProteomicsDB; 299925; -.
DR   Antibodypedia; 24215; 112 antibodies from 27 providers.
DR   DNASU; 240614; -.
DR   Ensembl; ENSMUST00000099525; ENSMUSP00000100503; ENSMUSG00000074909.
DR   GeneID; 240614; -.
DR   KEGG; mmu:240614; -.
DR   UCSC; uc008heb.2; mouse.
DR   CTD; 26953; -.
DR   MGI; MGI:2683212; Ranbp6.
DR   VEuPathDB; HostDB:ENSMUSG00000074909; -.
DR   eggNOG; KOG2171; Eukaryota.
DR   GeneTree; ENSGT00940000162767; -.
DR   HOGENOM; CLU_003794_0_0_1; -.
DR   InParanoid; Q8BIV3; -.
DR   OMA; FWHFPGI; -.
DR   OrthoDB; 90499at2759; -.
DR   PhylomeDB; Q8BIV3; -.
DR   TreeFam; TF300344; -.
DR   BioGRID-ORCS; 240614; 0 hits in 73 CRISPR screens.
DR   ChiTaRS; Ranbp6; mouse.
DR   PRO; PR:Q8BIV3; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q8BIV3; protein.
DR   Bgee; ENSMUSG00000074909; Expressed in medial vestibular nucleus and 218 other tissues.
DR   ExpressionAtlas; Q8BIV3; baseline and differential.
DR   Genevisible; Q8BIV3; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR040122; Importin_beta.
DR   InterPro; IPR041653; Importin_rep_4.
DR   InterPro; IPR041389; Importin_rep_6.
DR   PANTHER; PTHR10527; PTHR10527; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF18808; Importin_rep_4; 1.
DR   Pfam; PF18829; Importin_rep_6; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Nucleus; Protein transport; Reference proteome;
KW   Repeat; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O60518"
FT   CHAIN           2..1105
FT                   /note="Ran-binding protein 6"
FT                   /id="PRO_0000120780"
FT   REPEAT          219..257
FT                   /note="HEAT 1"
FT   REPEAT          361..399
FT                   /note="HEAT 2"
FT   REPEAT          402..440
FT                   /note="HEAT 3"
FT   REPEAT          444..483
FT                   /note="HEAT 4"
FT   REPEAT          866..905
FT                   /note="HEAT 5"
FT   REPEAT          908..946
FT                   /note="HEAT 6"
FT   REPEAT          949..987
FT                   /note="HEAT 7"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:O60518"
FT   CONFLICT        1105
FT                   /note="A -> CLKQFNTIYHKSSYNVS (in Ref. 2; BAE36329)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1105 AA;  124587 MW;  A79A4D2F0BEB4578 CRC64;
     MAAAGSAGLP ATVSEKQEFY QLLKNLINPS CMVRRQAEEV YENIPGLCKT TFLLDAVRNR
     RAGYEVRQMA AALLRRLLSS GFEEVYPNLP PEVQRDVKIE LILAVKLETH ASMRKKLCDI
     FAVLARNLID ESGTNHWPEG LKFLIDSIHS KNVVLWEVAL HVFWHFPGIF GNQDRHDLDI
     IKRLLDQCIQ DQEHPAIRTL SARAAATFVL ANENNIALFK DFADLLPGIL QAVNDSCYQD
     DDSVLESLVE IADTVPKYLG PYLEDTLQLS LKLCGDSRLS NLQRQLALEV IVTLSETATP
     MLKKHTNIIA QAVPHILAMM VDLQDDDDWV NADEMEEDDF DSNAVAAESA LDRLACGLGG
     KVVLPMTKEH IMQMLQSPDW KCRHAGLMAL SAIGEGCHQQ MEPILDETVN SVLLFLQDPH
     PRVRAAACTT LGQMATDFAP SFQKKFHEIV ITALLRTMEN QGNQRVQSHA ASALVIFIED
     CPKSLLILYL ENMVKSLHSI LVIKLQELIR NGTKLALEQL VTTIASVADA IEESFIPYYD
     IFMPSLKHVV ELAVQKELKL LRGKTIECIS HVGLAVGKEK FMQDASNVMQ LLLKTQSDLN
     NMEDDDPQTS YMVSAWARMC KILGKDFEQY LPLVIEPLIK TASAKPDVAL LDTQDVENMS
     DDDGWQFVNL GDQQSFGIKT SGLEAKATAC QMLVYYAKEL REGFVEYTEQ VVKMMVPLLK
     FYFHDNVRVA AAEAMPFLLE CARIRGSEYL SQMWQFICDP LIKAIGTEPD TDVLSEIMNS
     FAKSIEVMGD GCLNDEHLEE LGGILKAKLE GHFKNQELRQ VKRQEENYDQ QVEMSLQDED
     ECDVYILTKV SDILHSLFST YKEKILPWFE QLLPLIVNLI CSSRPWPDRQ WGLCIFDDII
     EHCSPTSFKY VEYFRWPMLL NMRDNNPEVR QAAAYGLGVM AQFGGDDYRS LCSEAVPLLV
     KVIKCANSKT KKNVIATENC ISAIGKILKF KPNCVNVDEV LPHWLSWLPL HEDKEEAIQT
     LNFLCDLIES NHPVVIGPNN SNLPKIISII AEGKINETIS HEDPCAKRLA NVVRQIQTSE
     ELWLECTSQL DDEQQEALHE LLSFA