ID   RNB_AERHH               Reviewed;         673 AA.
AC   A0KFR1;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Exoribonuclease 2 {ECO:0000255|HAMAP-Rule:MF_01036};
DE            EC=3.1.13.1 {ECO:0000255|HAMAP-Rule:MF_01036};
DE   AltName: Full=Exoribonuclease II {ECO:0000255|HAMAP-Rule:MF_01036};
DE            Short=RNase II {ECO:0000255|HAMAP-Rule:MF_01036};
DE            Short=Ribonuclease II {ECO:0000255|HAMAP-Rule:MF_01036};
GN   Name=rnb {ECO:0000255|HAMAP-Rule:MF_01036}; OrderedLocusNames=AHA_0554;
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC
OS   13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC
RC   2358 / NCIMB 9240 / NCTC 8049;
RX   PubMed=16980456; DOI=10.1128/jb.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H.,
RA   Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA   Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Involved in mRNA degradation. Hydrolyzes single-stranded
CC       polyribonucleotides processively in the 3' to 5' direction.
CC       {ECO:0000255|HAMAP-Rule:MF_01036}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC         nucleoside 5'-phosphates.; EC=3.1.13.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01036};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01036}.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase II subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01036}.
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DR   EMBL; CP000462; ABK38105.1; -; Genomic_DNA.
DR   RefSeq; WP_011704526.1; NC_008570.1.
DR   RefSeq; YP_855087.1; NC_008570.1.
DR   AlphaFoldDB; A0KFR1; -.
DR   SMR; A0KFR1; -.
DR   STRING; 380703.AHA_0554; -.
DR   EnsemblBacteria; ABK38105; ABK38105; AHA_0554.
DR   KEGG; aha:AHA_0554; -.
DR   PATRIC; fig|380703.7.peg.548; -.
DR   eggNOG; COG4776; Bacteria.
DR   HOGENOM; CLU_002333_7_3_6; -.
DR   OMA; CFTNYLP; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.50.140; -; 2.
DR   HAMAP; MF_01036; RNase_II; 1.
DR   InterPro; IPR011129; CSD.
DR   InterPro; IPR040476; CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR013223; RNase_B_OB_dom.
DR   InterPro; IPR011804; RNase_II.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR004476; RNase_II/RNase_R.
DR   Pfam; PF17876; CSD2; 1.
DR   Pfam; PF08206; OB_RNB; 1.
DR   Pfam; PF00773; RNB; 1.
DR   SMART; SM00357; CSP; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; SSF50249; 4.
DR   TIGRFAMs; TIGR00358; 3_prime_RNase; 1.
DR   TIGRFAMs; TIGR02062; RNase_B; 1.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..673
FT                   /note="Exoribonuclease 2"
FT                   /id="PRO_0000409532"
FT   DOMAIN          562..645
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01036"
FT   REGION          650..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   673 AA;  75744 MW;  A01BFDE44D2B31A1 CRC64;
     MFQDNPLLAQ LKQQIRENIP KKEGVIRASD RGFGFLEVDE KTSYFVPPPY MKKVMHGDRV
     SALIRTEKEK EVAEPDALLE QSVTRFVARV KMFRDRLNVV ADHPLIKDAI KARVKKGLDE
     KEFKEGDWVV ATLKRHALVD GNFSAEITQT IASQEDHNVP WWVVLARHNL AQVEPADLPE
     WKVIEEEELP RTDLTATPFF TIDGAKTKDM DDALAIRKLD NGWELLVAIA DPTAYVAEGS
     ELDKEAAQRA FTVYMPGRNV PMIPRTLSDE LCSLKEGEER NTLCARLLIA EDGLLLEETE
     FFAARISSHA RLTYDDVSDW AEHGKQLDID AGVLAQLPLM KAMTEARIAW RTEHALVFPD
     RPDYDFELGE NGEVLAIHVE PRRIANRMVE ESMIAANICA GRVLGKQVGY GIFNVHTGFD
     EESLDGAIDL LKSAEAPFEK EEIASLSGFC ALRRWIDNLD TRWLDGKIRR FQSYALMSAE
     PGAHYGLGLD AYATWTSPIR KYGDMVNHRL LKAVIAGKTP GERPSLELTE HLTACRRLHR
     MVERDIGDWL YVRYLKADAG TDKVFNAEII DVMRAGLKLR LRENGAVVFM PARHILDNKD
     RLECNWDNGR VYLDKTEVVY ELGQIIEVKL TEAVEETRSL IAKPAVELVP GPAPVAPTSE
     ADATPADEAP KAE