ID   AB18B_ARATH             Reviewed;        1225 AA.
AC   Q9LSJ5;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=ABC transporter B family member 18;
DE            Short=ABC transporter ABCB.18;
DE            Short=AtABCB18;
DE   AltName: Full=P-glycoprotein 18;
DE   AltName: Full=Putative multidrug resistance protein 20;
GN   Name=ABCB18; Synonyms=MDR20, PGP18; OrderedLocusNames=At3g28390;
GN   ORFNames=MFJ20.7;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA   Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT   "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL   J. Biol. Chem. 276:30231-30244(2001).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA   Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA   Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA   Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT   "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL   Trends Plant Sci. 13:151-159(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC       Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC       Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
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DR   EMBL; AB026644; BAB02855.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE77440.1; -; Genomic_DNA.
DR   RefSeq; NP_189480.1; NM_113759.1.
DR   AlphaFoldDB; Q9LSJ5; -.
DR   SMR; Q9LSJ5; -.
DR   BioGRID; 7797; 1.
DR   STRING; 3702.AT3G28390.1; -.
DR   PaxDb; Q9LSJ5; -.
DR   PRIDE; Q9LSJ5; -.
DR   EnsemblPlants; AT3G28390.1; AT3G28390.1; AT3G28390.
DR   GeneID; 822468; -.
DR   Gramene; AT3G28390.1; AT3G28390.1; AT3G28390.
DR   KEGG; ath:AT3G28390; -.
DR   Araport; AT3G28390; -.
DR   TAIR; locus:2088942; AT3G28390.
DR   eggNOG; KOG0055; Eukaryota.
DR   HOGENOM; CLU_000604_17_2_1; -.
DR   InParanoid; Q9LSJ5; -.
DR   OMA; FIIACSY; -.
DR   OrthoDB; 186078at2759; -.
DR   PhylomeDB; Q9LSJ5; -.
DR   BioCyc; ARA:AT3G28390-MON; -.
DR   PRO; PR:Q9LSJ5; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LSJ5; differential.
DR   Genevisible; Q9LSJ5; AT.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1560.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR24221; PTHR24221; 1.
DR   Pfam; PF00664; ABC_membrane; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF90123; SSF90123; 2.
DR   PROSITE; PS50929; ABC_TM1F; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Glycoprotein; Membrane; Nucleotide-binding;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1225
FT                   /note="ABC transporter B family member 18"
FT                   /id="PRO_0000227931"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        146..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        172..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        657..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        699..719
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        780..800
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        804..824
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        880..900
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        919..939
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          23..312
FT                   /note="ABC transmembrane type-1 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          347..583
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          657..945
FT                   /note="ABC transmembrane type-1 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          980..1218
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         382..389
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         1015..1022
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   CARBOHYD        530
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        754
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        960
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1000
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1201
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1225 AA;  134303 MW;  DCB4E5D590F4D782 CRC64;
     MMKSFGSIRS IFMHADGVDW MLMALGLIGA VGDGFITPII FFICSKLLNN VGGSSFDDET
     FMQTVAKNAV ALVYVACASW VICFIEGYCW TRTGERQAAK MREKYLKAVL RQDVGYFDLH
     VTSTSDVITS VSSDSLVIQD FLSEKLPNFL MNTSAFVASY IVGFLLLWRL TIVGFPFIIL
     LLIPGLMYGR ALIRISMKIR EEYNEAGSIA EQVISSVRTV YAFGSEKKMI EKFSTALQGS
     VKLGLRQGLA KGIAIGSNGI TYAIWGFLTW YGSRMVMNHG SKGGTVSSVI VCVTFGGTSL
     GQSLSNLKYF SEAFVVGERI MKVINRVPGI DSDNLEGQIL EKTRGEVEFN HVKFTYPSRP
     ETPIFDDLCL RVPSGKTVAL VGGSGSGKST VISLLQRFYD PIAGEILIDG LPINKLQVKW
     LRSQMGLVSQ EPVLFATSIK ENILFGKEDA SMDEVVEAAK ASNAHSFISQ FPNSYQTQVG
     ERGVQLSGGQ KQRIAIARAI IKSPIILLLD EATSALDSES ERVVQEALDN ASIGRTTIVI
     AHRLSTIRNA DVICVVHNGR IIETGSHEEL LEKLDGQYTS LVRLQQVDNK ESDHISVEEG
     QASSLSKDLK YSPKEFIHST SSNIVRDFPN LSPKDGKSLV PSFKRLMSMN RPEWKHALYG
     CLGAALFGAV QPIYSYSSGS MVSVYFLASH DQIKEKTRIY VLLFVGLALF TFLSNISQHY
     GFAYMGEYLT KRIRERMLGK ILTFEVNWFD KDENSSGAIC SRLAKDANMV RSLVGDRMSL
     LVQTISAVSI TCAIGLVISW RFSIVMMSVQ PVIVVCFYTQ RVLLKSMSRN AIKGQDESSK
     LAAEAVSNIR TITAFSSQER IINLLKMVQE GPRKDSARQS WLAGIMLGTS QSLITCVSAL
     NFWYGGKLIA DGKMMSKEFL EIFLIFASTG RVIAEAGTMT KDLVKGSDAV ASVFAVLDRN
     TTIEPENPDG YVPKKVKGQI SFSNVDFAYP TRPDVIIFQN FSIDIEDGKS TAIVGPSGSG
     KSTIISLIER FYDPLKGIVK IDGRDIRSCH LRSLRQHIAL VSQEPTLFAG TIRENIMYGG
     ASNKIDESEI IEAAKAANAH DFITSLSNGY DTCCGDRGVQ LSGGQKQRIA IARAVLKNPS
     VLLLDEATSA LDSQSESVVQ DALERLMVGR TSVVIAHRLS TIQKCDTIAV LENGAVVECG
     NHSSLLAKGP KGAYFSLVSL QRTLF