ID   RNB_SODGM               Reviewed;         644 AA.
AC   Q2NST6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Exoribonuclease 2 {ECO:0000255|HAMAP-Rule:MF_01036};
DE            EC=3.1.13.1 {ECO:0000255|HAMAP-Rule:MF_01036};
DE   AltName: Full=Exoribonuclease II {ECO:0000255|HAMAP-Rule:MF_01036};
DE            Short=RNase II {ECO:0000255|HAMAP-Rule:MF_01036};
DE            Short=Ribonuclease II {ECO:0000255|HAMAP-Rule:MF_01036};
GN   Name=rnb {ECO:0000255|HAMAP-Rule:MF_01036}; OrderedLocusNames=SG1514;
OS   Sodalis glossinidius (strain morsitans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Bruguierivoracaceae; Sodalis.
OX   NCBI_TaxID=343509;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=morsitans;
RX   PubMed=16365377; DOI=10.1101/gr.4106106;
RA   Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M.,
RA   Aksoy S.;
RT   "Massive genome erosion and functional adaptations provide insights into
RT   the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
RL   Genome Res. 16:149-156(2006).
CC   -!- FUNCTION: Involved in mRNA degradation. Hydrolyzes single-stranded
CC       polyribonucleotides processively in the 3' to 5' direction.
CC       {ECO:0000255|HAMAP-Rule:MF_01036}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC         nucleoside 5'-phosphates.; EC=3.1.13.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01036};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01036}.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase II subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01036}.
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DR   EMBL; AP008232; BAE74789.1; -; Genomic_DNA.
DR   RefSeq; WP_011411334.1; NC_007712.1.
DR   AlphaFoldDB; Q2NST6; -.
DR   SMR; Q2NST6; -.
DR   STRING; 343509.SG1514; -.
DR   EnsemblBacteria; BAE74789; BAE74789; SG1514.
DR   KEGG; sgl:SG1514; -.
DR   eggNOG; COG4776; Bacteria.
DR   HOGENOM; CLU_002333_7_3_6; -.
DR   OMA; CFTNYLP; -.
DR   OrthoDB; 1602988at2; -.
DR   BioCyc; SGLO343509:SGP1_RS13470-MON; -.
DR   Proteomes; UP000001932; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.50.140; -; 2.
DR   HAMAP; MF_01036; RNase_II; 1.
DR   InterPro; IPR011129; CSD.
DR   InterPro; IPR040476; CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR013223; RNase_B_OB_dom.
DR   InterPro; IPR011804; RNase_II.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR004476; RNase_II/RNase_R.
DR   InterPro; IPR003029; S1_domain.
DR   Pfam; PF17876; CSD2; 1.
DR   Pfam; PF08206; OB_RNB; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00357; CSP; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; SSF50249; 4.
DR   TIGRFAMs; TIGR00358; 3_prime_RNase; 1.
DR   TIGRFAMs; TIGR02062; RNase_B; 1.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; RNA-binding.
FT   CHAIN           1..644
FT                   /note="Exoribonuclease 2"
FT                   /id="PRO_1000063902"
FT   DOMAIN          562..644
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01036"
SQ   SEQUENCE   644 AA;  72631 MW;  D8B2751D81B856E3 CRC64;
     MFQDNPLLAQ LKQQLHSQTP RVEGVVKGTE KGFGFLEVDA QKSYFISPPF MKKVMHGDKI
     SAVVRTEKER EIAEPEELIE PFLTRFIGRV QVKDERLAVV PDHPLIKEVI PTRPQHGVDQ
     MFQTGDWAVA EMRRHPLKGD RQFYAEITAL VTRADDHFAP WWVTLARHNL ERAAPTMPEG
     VSLQEDGPAR EDLTALDFIT IDSASTEDMD DAIHLAPAPN GAWVMTVAIA DPTAWVPAGS
     PLDNIARERA FTNYLPGFNI PMLPRALSDD LCSLRAHERR PALACRVTVR PNGTLADDAR
     FFTAWIESKG KLAYDNVSDW LENLGSWQPE TEAIADQIRL LHDVCLARSA WRQRHALVFK
     DRPDYRFVLN EKGNVDDIVV EPRRIANRMI EEAMITANVC AARVLRDGLG YGLYNVHHGF
     DPLLVDQAVA ILHSHQIEVD PADLLTLEGF CALRRRLDAQ PTSYLDSRIR RFQTFAEVST
     VPGPHFGLGL DAYATWTSPI RKYGDMINHR LLKALIGVGD AERPNEEVTL RLAERRRQNR
     MAERDVGDWL YARFLQPKAG SDSRFAAEII DISRGGMRVR LLNNGAVAFI PAPFIHSVRD
     ELVCSQDTGT VQVKGEERYR QGDTLDVTLA EVRMENRSVI ARPV