ID   RNB_VIBA3               Reviewed;         668 AA.
AC   B7VSB8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Exoribonuclease 2 {ECO:0000255|HAMAP-Rule:MF_01036};
DE            EC=3.1.13.1 {ECO:0000255|HAMAP-Rule:MF_01036};
DE   AltName: Full=Exoribonuclease II {ECO:0000255|HAMAP-Rule:MF_01036};
DE            Short=RNase II {ECO:0000255|HAMAP-Rule:MF_01036};
DE            Short=Ribonuclease II {ECO:0000255|HAMAP-Rule:MF_01036};
GN   Name=rnb {ECO:0000255|HAMAP-Rule:MF_01036}; OrderedLocusNames=VS_II1138;
OS   Vibrio atlanticus (strain LGP32) (Vibrio splendidus (strain Mel32)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=575788;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LGP32;
RA   Mazel D., Le Roux F.;
RT   "Vibrio splendidus str. LGP32 complete genome.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in mRNA degradation. Hydrolyzes single-stranded
CC       polyribonucleotides processively in the 3' to 5' direction.
CC       {ECO:0000255|HAMAP-Rule:MF_01036}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC         nucleoside 5'-phosphates.; EC=3.1.13.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01036};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01036}.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase II subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01036}.
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DR   EMBL; FM954973; CAV27060.1; -; Genomic_DNA.
DR   RefSeq; WP_012600986.1; NC_011744.2.
DR   AlphaFoldDB; B7VSB8; -.
DR   SMR; B7VSB8; -.
DR   STRING; 575788.VS_II1138; -.
DR   EnsemblBacteria; CAV27060; CAV27060; VS_II1138.
DR   KEGG; vsp:VS_II1138; -.
DR   PATRIC; fig|575788.5.peg.1072; -.
DR   eggNOG; COG4776; Bacteria.
DR   HOGENOM; CLU_002333_7_3_6; -.
DR   OMA; CFTNYLP; -.
DR   OrthoDB; 1602988at2; -.
DR   Proteomes; UP000009100; Chromosome 2.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.50.140; -; 2.
DR   HAMAP; MF_01036; RNase_II; 1.
DR   InterPro; IPR011129; CSD.
DR   InterPro; IPR040476; CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR013223; RNase_B_OB_dom.
DR   InterPro; IPR011804; RNase_II.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR004476; RNase_II/RNase_R.
DR   InterPro; IPR022967; S1_dom.
DR   InterPro; IPR003029; S1_domain.
DR   Pfam; PF17876; CSD2; 1.
DR   Pfam; PF08206; OB_RNB; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00357; CSP; 1.
DR   SMART; SM00955; RNB; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; SSF50249; 4.
DR   TIGRFAMs; TIGR00358; 3_prime_RNase; 1.
DR   TIGRFAMs; TIGR02062; RNase_B; 1.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..668
FT                   /note="Exoribonuclease 2"
FT                   /id="PRO_1000149461"
FT   DOMAIN          568..650
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01036"
SQ   SEQUENCE   668 AA;  75202 MW;  1F3A3F0837DA33AC CRC64;
     MFQDNPLLAQ LKQQIQETLP KKEGTIKATE KGFGFLEVDS KTSFFIPPPY MKKCVHGDKV
     IAIIRTEKER EVAEPEELIE QGLTRFIARV KLFKGRLNVV PDHPQLKKLQ LKAKAKKGLN
     PETLKEGDWV VAHIVQHPLK GDNGFLAQIS EKITDADDKI APWWVTLAQN DLPNSEPEGI
     DDWQIKDDAD LERVDMTHVP FVTIDGESTK DMDDALYAKK KENGDFELTI AIADPTAYIS
     PDDAMDKVAR ERGFTIYLPG RNIPMLPRDL ADNLCSLIEN EVRPALCCTV TVSKDGVIGD
     DINFFAANIK SHARLAYDHV SDWLETGASE KWQPSEEIAA IVSDLHQFAQ ARSAWRSANA
     VVFPDRPDYR FELSEDNDVV AIHADMRRSA NKLVEESMIS ANICAGRVLK ESFNQGVFNC
     HSGFKAEKLT DVLELVNPEA ETPFTEEQIV SLEGFATLRR WLGSLDNSYY DNRIRKFQAY
     SEISNEPAPH YAMGLDIYAT WTSPIRKYGD MINHRMLKAH ILRKTPTQTP DETIGDELAL
     HRRHHGMAER NVGDWLYART LANAPVEETR FQAEIFDINR AGMRVRLLEN GAAAFIPGSL
     ILNNKERIEC NGDMGTVSID KEMVYKLGDV LEVVLSEVNQ ENRNLVAKPT QVFADLPSGP
     ETTNETEA