AB18G_ARATH
ID AB18G_ARATH Reviewed; 708 AA.
AC Q9M2V5; Q0WQX8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=ABC transporter G family member 18;
DE Short=ABC transporter ABCG.18;
DE Short=AtABCG18;
DE AltName: Full=Probable white-brown complex homolog protein 18;
DE Short=AtWBC18;
GN Name=ABCG18; Synonyms=WBC18; OrderedLocusNames=At3g55110;
GN ORFNames=T15C9.110;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
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DR EMBL; AL132970; CAB82706.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79341.1; -; Genomic_DNA.
DR EMBL; AK228550; BAF00471.1; -; mRNA.
DR PIR; T47650; T47650.
DR RefSeq; NP_191071.1; NM_115369.4.
DR AlphaFoldDB; Q9M2V5; -.
DR SMR; Q9M2V5; -.
DR STRING; 3702.AT3G55110.1; -.
DR iPTMnet; Q9M2V5; -.
DR PaxDb; Q9M2V5; -.
DR PRIDE; Q9M2V5; -.
DR ProteomicsDB; 245095; -.
DR EnsemblPlants; AT3G55110.1; AT3G55110.1; AT3G55110.
DR GeneID; 824677; -.
DR Gramene; AT3G55110.1; AT3G55110.1; AT3G55110.
DR KEGG; ath:AT3G55110; -.
DR Araport; AT3G55110; -.
DR TAIR; locus:2097218; AT3G55110.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_8_1; -.
DR InParanoid; Q9M2V5; -.
DR OMA; AQERMSF; -.
DR OrthoDB; 1022017at2759; -.
DR PhylomeDB; Q9M2V5; -.
DR PRO; PR:Q9M2V5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M2V5; baseline and differential.
DR Genevisible; Q9M2V5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..708
FT /note="ABC transporter G family member 18"
FT /id="PRO_0000240690"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 537..557
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 589..609
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 681..701
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 75..317
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 402..612
FT /note="ABC transmembrane type-2"
FT BINDING 109..116
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 538
FT /note="I -> V (in Ref. 3; BAF00471)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 708 AA; 78700 MW; D317422F21F5E5D9 CRC64;
MPRVSAEILD ISHTGGNESP TLGELLKDFN DSGRKKYPGE NAPTQHILDL APAAETRSVP
FLLSFNNLSY NVVLRRRFDF SRRKTASVKT LLDDITGEAR DGEILAVLGG SGAGKSTLID
ALAGRVAEDS LKGTVTLNGE KVLQSRLLKV ISAYVMQDDL LFPMLTVKET LMFASEFRLP
RSLPKSKKME RVETLIDQLG LRNAADTVIG DEGHRGVSGG ERRRVSIGID IIHDPILLFL
DEPTSGLDST NAFMVVQVLK RIAQSGSVVI MSIHQPSARI IGLLDRLIIL SHGKSVFNGS
PVSLPSFFSS FGRPIPEKEN ITEFALDVIR ELEGSSEGTR DLVEFNEKWQ QNQTARATTQ
SRVSLKEAIA ASVSRGKLVS GSSGANPISM ETVSSYANPP LAETFILAKR YIKNWIRTPE
LIGMRIGTVM VTGLLLATVY WRLDNTPRGA QERMGFFAFG MSTMFYCCAD NIPVFIQERY
IFLRETTHNA YRTSSYVISH ALVSLPQLLA LSIAFAATTF WTVGLSGGLE SFFYYCLIIY
AAFWSGSSIV TFISGLIPNV MMSYMVTIAY LSYCLLLGGF YINRDRIPLY WIWFHYISLL
KYPYEAVLIN EFDDPSRCFV KGVQVFDGTL LAEVSHVMKV KLLDTLSGSL GTKITESTCL
RTGPDLLMQQ GITQLSKWDC LWITLAWGLF FRILFYLSLL FGSKNKRT
