ID   RNC_FRG3G               Reviewed;         371 AA.
AC   Q6GZP5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   02-DEC-2020, entry version 51.
DE   RecName: Full=Putative ribonuclease 3;
DE            EC=3.1.26.3;
DE   AltName: Full=Ribonuclease III;
DE            Short=RNase III;
GN   ORFNames=FV3-080L;
OS   Frog virus 3 (isolate Goorha) (FV-3).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Alphairidovirinae; Ranavirus.
OX   NCBI_TaxID=654924;
OH   NCBI_TaxID=30343; Dryophytes versicolor (chameleon treefrog).
OH   NCBI_TaxID=8404; Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OH   NCBI_TaxID=45438; Lithobates sylvaticus (Wood frog) (Rana sylvatica).
OH   NCBI_TaxID=8316; Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15165820; DOI=10.1016/j.virol.2004.02.019;
RA   Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.;
RT   "Comparative genomic analyses of frog virus 3, type species of the genus
RT   Ranavirus (family Iridoviridae).";
RL   Virology 323:70-84(2004).
CC   -!- FUNCTION: Digests double-stranded RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3;
CC   -!- SIMILARITY: Belongs to the IIV-6 142R family. {ECO:0000305}.
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DR   EMBL; AY548484; AAT09740.1; -; Genomic_DNA.
DR   RefSeq; YP_031659.1; NC_005946.1.
DR   SMR; Q6GZP5; -.
DR   PRIDE; Q6GZP5; -.
DR   GeneID; 2947799; -.
DR   KEGG; vg:2947799; -.
DR   Proteomes; UP000008770; Genome.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd00593; RIBOc; 1.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF00636; Ribonuclease_3; 1.
DR   SMART; SM00535; RIBOc; 1.
DR   SUPFAM; SSF69065; SSF69065; 1.
DR   PROSITE; PS50142; RNASE_3_2; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding.
FT   CHAIN           1..371
FT                   /note="Putative ribonuclease 3"
FT                   /id="PRO_0000410590"
FT   DOMAIN          10..136
FT                   /note="RNase III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00177"
SQ   SEQUENCE   371 AA;  40362 MW;  86638E1130E44E6A CRC64;
     MEGWLGNLLA KSVKDKYIPV IVGRRDLWNK VFTPKSVNPD DNYEALEIVG DGVASYFFPS
     YFLKRFPQLN SPKGVKTVAR LKIYYGSKKS FSSIADSLGF WKFIRSGPVP VNPSTRESLL
     EDTFEAFLGA VCMAVDDEYS IDGLGAVVAY KIMADIFDDM DISLEYTALF DTVTRLKELM
     DVKKDVLGGD AVYNHRGDTT VITLKGRVIG KATGAIKRDR AKEAAGQALD LLRREGHFRE
     HDDDAVVKVA KGPAGDGLVV AQSALGGFTV FGAESGVVEG SGGTVAQALS RVVGTKRPSA
     VEVAGGDYKS LLKEYLESVG ETDSVNYIHE GVTVTMTRKG KPVATANHLV KKVREQLASR
     DYYRTVHAKG V