ID   RNC_IIV3                Reviewed;         333 AA.
AC   Q196V9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   23-FEB-2022, entry version 57.
DE   RecName: Full=Putative ribonuclease 3;
DE            EC=3.1.26.3;
GN   ORFNames=IIV3-101R;
OS   Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Betairidovirinae; Chloriridovirus.
OX   NCBI_TaxID=345201;
OH   NCBI_TaxID=7163; Aedes vexans (Inland floodwater mosquito) (Culex vexans).
OH   NCBI_TaxID=42431; Culex territans.
OH   NCBI_TaxID=332058; Culiseta annulata.
OH   NCBI_TaxID=310513; Ochlerotatus sollicitans (eastern saltmarsh mosquito).
OH   NCBI_TaxID=329105; Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus).
OH   NCBI_TaxID=7183; Psorophora ferox.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16912294; DOI=10.1128/jvi.00464-06;
RA   Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A.,
RA   Kutish G.F., Rock D.L.;
RT   "Genome of invertebrate iridescent virus type 3 (mosquito iridescent
RT   virus).";
RL   J. Virol. 80:8439-8449(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3;
CC   -!- SIMILARITY: Belongs to the IIV-6 142R family. {ECO:0000305}.
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DR   EMBL; DQ643392; ABF82131.1; -; Genomic_DNA.
DR   RefSeq; YP_654673.1; NC_008187.1.
DR   SMR; Q196V9; -.
DR   GeneID; 4156245; -.
DR   KEGG; vg:4156245; -.
DR   Proteomes; UP000001358; Genome.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd00593; RIBOc; 1.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF00636; Ribonuclease_3; 1.
DR   SMART; SM00535; RIBOc; 1.
DR   SUPFAM; SSF69065; SSF69065; 1.
DR   PROSITE; PS50142; RNASE_3_2; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding.
FT   CHAIN           1..333
FT                   /note="Putative ribonuclease 3"
FT                   /id="PRO_0000376953"
FT   DOMAIN          81..208
FT                   /note="RNase III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00177"
FT   DOMAIN          250..319
FT                   /note="DRBM"
SQ   SEQUENCE   333 AA;  38408 MW;  721A2F2A2FD5B4C8 CRC64;
     MLVCTNRPPV SPVLQLCRFA SNVVLFHLKI VKQIKFEFLN VFNLKIKRLQ METEVYYGPR
     DDSFKDFLIK IFKLMDMGST RSETSNFLNT YINEETLPYF NMAFTSSSAN ELNNYELFEQ
     MGDSTIGKFI VWSSYEKFPQ LRGKPEAVEI VARMKINLGS KDNLSQIAED LGMWTFISAT
     EEARHRLKKK LLEDVFEALI GVTEYIIYEF TDTNYSQPGL AYQLVYSLLL KLFDPYILKI
     DYNTLVDSKN RLKGVFDQYK DKLGLQPVYQ SERIVKNDKN VFLSKVYDGN GNFLGEGTAP
     LKKEAEKKAS EVAILTLISN GYKKNIPSLY ETL