ID   RNC_IIV6                Reviewed;         292 AA.
AC   O55748;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   23-FEB-2022, entry version 80.
DE   RecName: Full=Putative ribonuclease 3;
DE            EC=3.1.26.3;
DE   AltName: Full=Ribonuclease III;
DE            Short=RNase III;
GN   ORFNames=IIV6-142R;
OS   Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Betairidovirinae; Iridovirus.
OX   NCBI_TaxID=176652;
OH   NCBI_TaxID=6997; Acheta domesticus (House cricket).
OH   NCBI_TaxID=168631; Chilo suppressalis (Asiatic rice borer moth).
OH   NCBI_TaxID=6999; Gryllus bimaculatus (Two-spotted cricket).
OH   NCBI_TaxID=58607; Gryllus campestris.
OH   NCBI_TaxID=7108; Spodoptera frugiperda (Fall armyworm).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11448171; DOI=10.1006/viro.2001.0963;
RA   Jakob N.J., Mueller K., Bahr U., Darai G.;
RT   "Analysis of the first complete DNA sequence of an invertebrate iridovirus:
RT   coding strategy of the genome of Chilo iridescent virus.";
RL   Virology 286:182-196(2001).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=17239238; DOI=10.1186/1743-422x-4-11;
RA   Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.;
RT   "Comparative genomic analysis of the family Iridoviridae: re-annotating and
RT   defining the core set of iridovirus genes.";
RL   Virol. J. 4:11-11(2007).
CC   -!- FUNCTION: Digests double-stranded RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3;
CC   -!- SIMILARITY: Belongs to the IIV-6 142R family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF303741; AAB94459.1; -; Genomic_DNA.
DR   PIR; T03085; T03085.
DR   RefSeq; NP_149605.1; NC_003038.1.
DR   SMR; O55748; -.
DR   GeneID; 1733045; -.
DR   KEGG; vg:1733045; -.
DR   Proteomes; UP000001359; Genome.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   SMART; SM00535; RIBOc; 1.
DR   SUPFAM; SSF69065; SSF69065; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS50142; RNASE_3_2; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding.
FT   CHAIN           1..292
FT                   /note="Putative ribonuclease 3"
FT                   /id="PRO_0000376954"
FT   DOMAIN          32..158
FT                   /note="RNase III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00177"
FT   DOMAIN          204..276
FT                   /note="DRBM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
SQ   SEQUENCE   292 AA;  33664 MW;  AEFBC85399291FC3 CRC64;
     MENNIENFDP SLVYFGDRGQ DFKKMIRSIL SLGMSDEYIP YLTTPESLNT YNTAFTSRGA
     DDKNNYEMFE QLGDVSVNKF IVNYMYKRFP QLRNPNGVDV VAKLKIKYAS KNQLQMLSES
     LDMWRFITAT YDERTNKKKP LLEDTFESFF GATEWLIDSF IEDIALKQGN NNTYVGVGYN
     IINGILTTLF DRINISLKYE NLVDAKTRFN EVIAEQKSII GDVKYEDEYK NGKHTSKIYR
     YPPNSNLKEL LGIGTGTLKR DAQEQAASRA LETLALKHNI IKEAPDRFKA FM