ID   RNC_MIMIV               Reviewed;         538 AA.
AC   Q5UQT7;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Probable ribonuclease 3;
DE            EC=3.1.26.3;
DE   AltName: Full=Ribonuclease III;
DE            Short=RNase III;
GN   OrderedLocusNames=MIMI_R343;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
CC   -!- FUNCTION: Digests double-stranded RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3;
CC   -!- SIMILARITY: Belongs to the ribonuclease III family. {ECO:0000305}.
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DR   EMBL; AY653733; AAV50612.1; -; Genomic_DNA.
DR   RefSeq; YP_003986845.1; NC_014649.1.
DR   SMR; Q5UQT7; -.
DR   GeneID; 9924960; -.
DR   KEGG; vg:9924960; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 2.
DR   HAMAP; MF_00104; RNase_III; 1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR011907; RNase_III.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF00035; dsrm; 2.
DR   Pfam; PF14622; Ribonucleas_3_3; 2.
DR   SMART; SM00358; DSRM; 2.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..538
FT                   /note="Probable ribonuclease 3"
FT                   /id="PRO_0000243980"
FT   DOMAIN          24..149
FT                   /note="RNase III 1"
FT   DOMAIN          238..381
FT                   /note="RNase III 2"
FT   DOMAIN          408..477
FT                   /note="DRBM"
SQ   SEQUENCE   538 AA;  63058 MW;  BDC3AD6D0CB4E904 CRC64;
     MSKFQNYYNN DDNVINYPYI DYIIKSYIPE YYVDTNRRKY VDMHIFEEAM LHVSTIYEES
     DKTYERLEYL GDAIFHMIIT EYFYHRYNEE NEGFLTRLRI RIERGDSMVE LSKNLGLNNF
     VQIYGISLND HILEDIFESF IGAFYLNFGM KYTRLFIIKL IEKHKNLSEL IAYDDNYKDL
     LLRYFHQMKW GHPKYIEEIV IDPKNNQRNK FISKVKNPFD KVIGIGSAST KKKSEQLASQ
     MALTNLGVII DGEIDTDWIN KIEKIETEAT QTEIKDKKPM SVFNPNNKLL SKNTIKNLLL
     QYNTKLPTID IDLKLFYEAM THRSYLIRKN LPNRDVPKSK SIVRLQKKSN ERLQFLGDAV
     IHFIIGEYLF NKYADSGEGY LTRLRCKLEN SESLFFLAKQ SDISSYLLIS QNIEVLHGRE
     NVNIIGGGLE AFVGALYLNI GLGTVKQFLL EIMRIELDIN QIAENETNYK DLILQLYNKN
     KWGHPVYKIL KEEGPDHCKI FTMGLYLGNK LMGIGKASSK KKAEQIASKK MYQNYINN