RND3_PIG
ID RND3_PIG Reviewed; 244 AA.
AC O77683;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Rho-related GTP-binding protein RhoE;
DE AltName: Full=Rho family GTPase 3;
DE AltName: Full=Rho-related GTP-binding protein Rho8;
DE AltName: Full=Rnd3;
DE Flags: Precursor;
GN Name=RND3; Synonyms=ARHE, RHO8, RHOE;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Smooth muscle;
RA Reichenberg S., Plenz G., Robenek H.;
RT "cDNA for porcine Rnd3/Rho8.";
RL Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds GTP but lacks intrinsic GTPase activity and is
CC resistant to Rho-specific GTPase-activating proteins. {ECO:0000250}.
CC -!- SUBUNIT: Binds ROCK1. Interacts with UBXD5 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC {ECO:0000305}.
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DR EMBL; AF078839; AAC28383.1; -; mRNA.
DR RefSeq; NP_999461.1; NM_214296.1.
DR AlphaFoldDB; O77683; -.
DR SMR; O77683; -.
DR STRING; 9823.ENSSSCP00000023328; -.
DR PaxDb; O77683; -.
DR PeptideAtlas; O77683; -.
DR PRIDE; O77683; -.
DR GeneID; 397559; -.
DR KEGG; ssc:397559; -.
DR CTD; 390; -.
DR eggNOG; KOG0393; Eukaryota.
DR InParanoid; O77683; -.
DR OrthoDB; 1283783at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd04172; Rnd3_RhoE_Rho8; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041843; RhoE.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072; PTHR24072; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51420; RHO; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW Nucleotide-binding; Prenylation; Reference proteome.
FT CHAIN 1..241
FT /note="Rho-related GTP-binding protein RhoE"
FT /id="PRO_0000198880"
FT PROPEP 242..244
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000281232"
FT MOTIF 52..60
FT /note="Effector region"
FT /evidence="ECO:0000255"
FT BINDING 30..37
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 77..81
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 135..138
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 241
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 241
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 244 AA; 27396 MW; 269084EF2FFF742E CRC64;
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGRTALL HVFAKDCFPE NYVPTVFENY
TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE
IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL
QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS
CTVM
