ID   RND3_RAT                Reviewed;         244 AA.
AC   Q6SA80;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Rho-related GTP-binding protein RhoE;
DE   AltName: Full=Rho family GTPase 3;
DE   AltName: Full=Rnd3;
DE   Flags: Precursor;
GN   Name=Rnd3; Synonyms=Arhe, Rhoe;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BDIX; TISSUE=Embryonic heart;
RA   Gill C.M., Stenson-Cox C., Samali A.;
RT   "Identification of RhoE as a gene modulated by heat shock in rat
RT   cardiomyocytes.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds GTP but lacks intrinsic GTPase activity and is
CC       resistant to Rho-specific GTPase-activating proteins. {ECO:0000250}.
CC   -!- SUBUNIT: Binds ROCK1. Interacts with UBXD5 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC       {ECO:0000305}.
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DR   EMBL; AY461427; AAR23526.1; -; mRNA.
DR   RefSeq; NP_001007642.1; NM_001007641.1.
DR   AlphaFoldDB; Q6SA80; -.
DR   SMR; Q6SA80; -.
DR   BioGRID; 255043; 1.
DR   STRING; 10116.ENSRNOP00000006111; -.
DR   PaxDb; Q6SA80; -.
DR   Ensembl; ENSRNOT00000006111; ENSRNOP00000006111; ENSRNOG00000004624.
DR   GeneID; 295588; -.
DR   KEGG; rno:295588; -.
DR   UCSC; RGD:1359690; rat.
DR   CTD; 390; -.
DR   RGD; 1359690; Rnd3.
DR   eggNOG; KOG0393; Eukaryota.
DR   GeneTree; ENSGT00940000157541; -.
DR   HOGENOM; CLU_041217_21_1_1; -.
DR   InParanoid; Q6SA80; -.
DR   OMA; RPCQKSS; -.
DR   OrthoDB; 1283783at2759; -.
DR   PhylomeDB; Q6SA80; -.
DR   TreeFam; TF330887; -.
DR   Reactome; R-RNO-9696264; RND3 GTPase cycle.
DR   PRO; PR:Q6SA80; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000004624; Expressed in ovary and 20 other tissues.
DR   ExpressionAtlas; Q6SA80; baseline and differential.
DR   Genevisible; Q6SA80; RN.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0030865; P:cortical cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd04172; Rnd3_RhoE_Rho8; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041843; RhoE.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   PANTHER; PTHR24072; PTHR24072; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Prenylation; Reference proteome.
FT   CHAIN           1..241
FT                   /note="Rho-related GTP-binding protein RhoE"
FT                   /id="PRO_0000198881"
FT   PROPEP          242..244
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000281234"
FT   MOTIF           52..60
FT                   /note="Effector region"
FT                   /evidence="ECO:0000255"
FT   BINDING         30..37
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         77..81
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         135..138
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         241
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           241
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   244 AA;  27368 MW;  DD2D4021CD42BACC CRC64;
     MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY
     TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE
     IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL
     QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS
     CTVM