RNF10_HUMAN
ID RNF10_HUMAN Reviewed; 811 AA.
AC Q8N5U6; Q92550; Q9NPP8; Q9ULW4;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=RING finger protein 10;
GN Name=RNF10; Synonyms=KIAA0262, RIE2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10697961; DOI=10.1007/s100380050007;
RA Seki N., Hattori A., Sugano S., Muramatsu M., Saito T.;
RT "cDNA cloning, expression profile, and genomic structure of human and mouse
RT RNF10/Rnf 10 genes, encoding a novel RING finger protein.";
RL J. Hum. Genet. 45:38-42(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Bone marrow;
RX PubMed=9039502; DOI=10.1093/dnares/3.5.321;
RA Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA Tanaka A., Kotani H., Miyajima N., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. VI. The
RT coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of
RT cDNA clones from cell line KG-1 and brain.";
RL DNA Res. 3:321-329(1996).
RN [3]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, Eye, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-811 (ISOFORM 2), AND VARIANT
RP PHE-332.
RG The European IMAGE consortium;
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH MEOX2.
RX PubMed=16335786; DOI=10.1007/s11010-005-0823-3;
RA Lin J., Friesen M.T., Bocangel P., Cheung D., Rawszer K., Wigle J.T.;
RT "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor
RT binding to RING finger protein 10.";
RL Mol. Cell. Biochem. 275:75-84(2005).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; SER-110 AND SER-128, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Transcriptional factor involved in the regulation of MAG
CC (Myelin-associated glycoprotein) expression. Acts as a regulator of
CC Schwann cell differentiation and myelination.
CC {ECO:0000250|UniProtKB:Q5XI59}.
CC -!- SUBUNIT: Interacts with MEOX2. {ECO:0000269|PubMed:16335786}.
CC -!- INTERACTION:
CC Q8N5U6; P55212: CASP6; NbExp=3; IntAct=EBI-714023, EBI-718729;
CC Q8N5U6; O94985-2: CLSTN1; NbExp=3; IntAct=EBI-714023, EBI-16041593;
CC Q8N5U6; Q8NI60: COQ8A; NbExp=3; IntAct=EBI-714023, EBI-745535;
CC Q8N5U6; G5E9A7: DMWD; NbExp=3; IntAct=EBI-714023, EBI-10976677;
CC Q8N5U6; O00291: HIP1; NbExp=3; IntAct=EBI-714023, EBI-473886;
CC Q8N5U6; P04792: HSPB1; NbExp=3; IntAct=EBI-714023, EBI-352682;
CC Q8N5U6; O60333-2: KIF1B; NbExp=3; IntAct=EBI-714023, EBI-10975473;
CC Q8N5U6; P13473-2: LAMP2; NbExp=3; IntAct=EBI-714023, EBI-21591415;
CC Q8N5U6; O60260-5: PRKN; NbExp=3; IntAct=EBI-714023, EBI-21251460;
CC Q8N5U6; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-714023, EBI-5280197;
CC Q8N5U6; P62826: RAN; NbExp=3; IntAct=EBI-714023, EBI-286642;
CC Q8N5U6; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-714023, EBI-396669;
CC Q8N5U6; P37840: SNCA; NbExp=3; IntAct=EBI-714023, EBI-985879;
CC Q8N5U6; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-714023, EBI-5235340;
CC Q8N5U6; Q13148: TARDBP; NbExp=3; IntAct=EBI-714023, EBI-372899;
CC Q8N5U6; P54274: TERF1; NbExp=2; IntAct=EBI-714023, EBI-710997;
CC Q8N5U6; O76024: WFS1; NbExp=3; IntAct=EBI-714023, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16335786}. Nucleus
CC {ECO:0000250|UniProtKB:Q5XI59}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N5U6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N5U6-2; Sequence=VSP_021478;
CC -!- SIMILARITY: Belongs to the RNF10 family. {ECO:0000305}.
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DR EMBL; AB027196; BAA84708.1; -; mRNA.
DR EMBL; D87451; BAA13392.2; -; mRNA.
DR EMBL; BT006974; AAP35620.1; -; mRNA.
DR EMBL; BC016622; AAH16622.1; -; mRNA.
DR EMBL; BC031596; AAH31596.1; -; mRNA.
DR EMBL; BC101709; AAI01710.1; -; mRNA.
DR EMBL; BC101715; AAI01716.1; -; mRNA.
DR EMBL; AL389976; CAB97533.1; -; mRNA.
DR CCDS; CCDS81746.1; -. [Q8N5U6-2]
DR CCDS; CCDS9201.1; -. [Q8N5U6-1]
DR RefSeq; NP_001317403.1; NM_001330474.1. [Q8N5U6-2]
DR RefSeq; NP_055683.3; NM_014868.4. [Q8N5U6-1]
DR AlphaFoldDB; Q8N5U6; -.
DR SMR; Q8N5U6; -.
DR BioGRID; 115249; 78.
DR IntAct; Q8N5U6; 52.
DR MINT; Q8N5U6; -.
DR STRING; 9606.ENSP00000322242; -.
DR iPTMnet; Q8N5U6; -.
DR PhosphoSitePlus; Q8N5U6; -.
DR BioMuta; RNF10; -.
DR DMDM; 117949776; -.
DR EPD; Q8N5U6; -.
DR jPOST; Q8N5U6; -.
DR MassIVE; Q8N5U6; -.
DR MaxQB; Q8N5U6; -.
DR PaxDb; Q8N5U6; -.
DR PeptideAtlas; Q8N5U6; -.
DR PRIDE; Q8N5U6; -.
DR ProteomicsDB; 72099; -. [Q8N5U6-1]
DR ProteomicsDB; 72100; -. [Q8N5U6-2]
DR Antibodypedia; 18977; 196 antibodies from 25 providers.
DR DNASU; 9921; -.
DR Ensembl; ENST00000325954.9; ENSP00000322242.4; ENSG00000022840.17. [Q8N5U6-1]
DR Ensembl; ENST00000413266.6; ENSP00000415682.2; ENSG00000022840.17. [Q8N5U6-2]
DR GeneID; 9921; -.
DR KEGG; hsa:9921; -.
DR MANE-Select; ENST00000325954.9; ENSP00000322242.4; NM_014868.5; NP_055683.3.
DR UCSC; uc001typ.5; human. [Q8N5U6-1]
DR CTD; 9921; -.
DR DisGeNET; 9921; -.
DR GeneCards; RNF10; -.
DR HGNC; HGNC:10055; RNF10.
DR HPA; ENSG00000022840; Low tissue specificity.
DR MIM; 615998; gene.
DR neXtProt; NX_Q8N5U6; -.
DR OpenTargets; ENSG00000022840; -.
DR PharmGKB; PA34419; -.
DR VEuPathDB; HostDB:ENSG00000022840; -.
DR eggNOG; KOG2164; Eukaryota.
DR GeneTree; ENSGT00390000001731; -.
DR HOGENOM; CLU_018206_0_0_1; -.
DR InParanoid; Q8N5U6; -.
DR OMA; PCLLHYL; -.
DR OrthoDB; 1373540at2759; -.
DR PhylomeDB; Q8N5U6; -.
DR TreeFam; TF323455; -.
DR PathwayCommons; Q8N5U6; -.
DR SignaLink; Q8N5U6; -.
DR SIGNOR; Q8N5U6; -.
DR BioGRID-ORCS; 9921; 14 hits in 1120 CRISPR screens.
DR ChiTaRS; RNF10; human.
DR GeneWiki; RNF10; -.
DR GenomeRNAi; 9921; -.
DR Pharos; Q8N5U6; Tbio.
DR PRO; PR:Q8N5U6; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8N5U6; protein.
DR Bgee; ENSG00000022840; Expressed in left testis and 203 other tissues.
DR ExpressionAtlas; Q8N5U6; baseline and differential.
DR Genevisible; Q8N5U6; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0099147; C:extrinsic component of postsynaptic density membrane; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IDA:FlyBase.
DR GO; GO:0010626; P:negative regulation of Schwann cell proliferation; ISS:UniProtKB.
DR GO; GO:0031643; P:positive regulation of myelination; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0099527; P:postsynapse to nucleus signaling pathway; IEA:Ensembl.
DR GO; GO:0051865; P:protein autoubiquitination; IDA:FlyBase.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR039739; Mag2/Rnf10.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR12983; PTHR12983; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..811
FT /note="RING finger protein 10"
FT /id="PRO_0000259585"
FT ZN_FING 225..267
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..185
FT /note="Interaction with MEOX2"
FT /evidence="ECO:0000269|PubMed:16335786"
FT REGION 653..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 5
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 110
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 128
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 418
FT /note="K -> KSLLQQ (in isoform 2)"
FT /evidence="ECO:0000303|Ref.6"
FT /id="VSP_021478"
FT VARIANT 332
FT /note="L -> F (in dbSNP:rs17852961)"
FT /evidence="ECO:0000269|Ref.6"
FT /id="VAR_028967"
FT VARIANT 433
FT /note="E -> D (in dbSNP:rs16950277)"
FT /id="VAR_028968"
SQ SEQUENCE 811 AA; 89927 MW; 54BCB1F7D59AE1BA CRC64;
MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP KSDGKNSSGS
KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG GGSSKLFSSS FNGGRRDEVA
EAQRAEFSPA QFSGPKKINL NHLLNFTFEP RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL
FLQANCQFVV SEDQDYTAHF ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC
GHIFCWACIL HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE
KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV ALEQQLAEEK
HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE QLVLMAPLAK ESVFQPRKGV
LEYLSAFDEE TTEVCSLDTP SRPLALPLVE EEEAVSEPEP EGLPEACDDL ELADDNLKEG
TICTESSQQE PITKSGFTRL SSSPCYYFYQ AEDGQHMFLH PVNVRCLVRE YGSLERSPEK
ISATVVEIAG YSMSEDVRQR HRYLSHLPLT CEFSICELAL QPPVVSKETL EMFSDDIEKR
KRQRQKKARE ERRRERRIEI EENKKQGKYP EVHIPLENLQ QFPAFNSYTC SSDSALGPTS
TEGHGALSIS PLSRSPGSHA DFLLTPLSPT ASQGSPSFCV GSLEEDSPFP SFAQMLRVGK
AKADVWPKTA PKKDENSLVP PAPVDSDGES DNSDRVPVPS FQNSFSQAIE AAFMKLDTPA
TSDPLSEEKG GKKRKKQKQK LLFSTSVVHT K
