ID   RNF10_XENLA             Reviewed;         756 AA.
AC   Q32NQ8;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=RING finger protein 10;
GN   Name=rnf10;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a transcriptional factor participating in nerve
CC       development and Schawnn cell differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250|UniProtKB:Q5XI59}.
CC   -!- SIMILARITY: Belongs to the RNF10 family. {ECO:0000305}.
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DR   EMBL; BC108524; AAI08525.1; -; mRNA.
DR   RefSeq; NP_001089838.1; NM_001096369.1.
DR   AlphaFoldDB; Q32NQ8; -.
DR   BioGRID; 592685; 1.
DR   IntAct; Q32NQ8; 1.
DR   GeneID; 734904; -.
DR   KEGG; xla:734904; -.
DR   CTD; 734904; -.
DR   Xenbase; XB-GENE-866563; rnf10.S.
DR   OMA; PPAPNAM; -.
DR   OrthoDB; 1373540at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 734904; Expressed in lung and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0010626; P:negative regulation of Schwann cell proliferation; ISS:UniProtKB.
DR   GO; GO:0031643; P:positive regulation of myelination; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR039739; Mag2/Rnf10.
DR   InterPro; IPR018957; Znf_C3HC4_RING-type.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR12983; PTHR12983; 1.
DR   Pfam; PF00097; zf-C3HC4; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..756
FT                   /note="RING finger protein 10"
FT                   /id="PRO_0000259588"
FT   ZN_FING         206..248
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          682..702
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          725..756
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   756 AA;  85149 MW;  776812237B102ED6 CRC64;
     MPLSSQGSPA DMDPGSANTN KNQNRSGSAG PSGESKPKSE QKNGSGSKQR YNRKRENSYP
     KNETLAGQTR RSCPQKSKTF NKVPPQRGGN KQYGMGRREE VAETQRAEFS SAEYSGPKKI
     NLNHLLNFTF ESRGHPGGPH SANGHFGRRH KWANKPFNKE LFLQANCQFV VSDVNDYSVH
     FTDPDTLVSW DFVEQVRIFS HEVASCPICL YPPVAAKITR CGHIFCWPCI LHYLSLSEKD
     WSRCPICYSS IIKKDLKSVV ATETHLYSVG DKITMQLMRR EKGVLVAMPK SKWMKLDEPI
     HMGDLDHIQY SKLLLASWEQ ILNYVIAEEK FALFEQYNAE KETPEACFIE AAIQELQDRA
     ESLCTASKPE IEAATLSMKT LNFEATCDKP NTVMEKEVVH YISAFEEETM EPPCEDCSPT
     ESPPPDIPAV LETEENTVTD GVLPLLSQPE SKPKNDEPLA NSHYYYFYQA VDGQHVYLHP
     VNVRCLVHEY GSLERCPEKI TATVVEMDGF TMTEEVRRRH RYLCHLPLTC EFSICEIALG
     PPDVSVKTLE LFTEEVEKRK RLRQRKARDE QRREKRIEIE ENRKQGKYPE AYIALENFQQ
     FPAFSSSPVY SLSSVETQNF VSISPVSCSP TSQSGSLLGA ECSLDPSFTE DESRCPSFAQ
     MLRAGKAKPE TWPKAAHKNV AENTLTPATA DSDGESDCSE RVPVPSFQNS FSQAMEAAFL
     KLDTALPTPP SSVEKGGRRK KKQQKLLFST SIVHTK