RNF13_BOVIN
ID RNF13_BOVIN Reviewed; 380 AA.
AC Q0VD51;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=E3 ubiquitin-protein ligase RNF13;
DE EC=2.3.2.27;
DE AltName: Full=RING finger protein 13;
DE Flags: Precursor;
GN Name=RNF13;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: E3 ubiquitin-protein ligase that regulates cell
CC proliferation. Involved in apoptosis regulation. Mediates ER stress-
CC induced activation of JNK signaling pathway and apoptosis by promoting
CC ERN1 activation and splicing of XBP1 mRNA. Also involved in protein
CC trafficking and localization. {ECO:0000250|UniProtKB:O43567}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:O43567};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000250|UniProtKB:O43567}.
CC -!- SUBUNIT: Interacts with ERN1. {ECO:0000250|UniProtKB:O43567}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:O43567}; Single-pass type I membrane protein
CC {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:O54965};
CC Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane
CC {ECO:0000250|UniProtKB:O43567}; Single-pass type I membrane protein
CC {ECO:0000255}. Nucleus inner membrane {ECO:0000250|UniProtKB:O54965};
CC Single-pass type I membrane protein {ECO:0000255}. Note=Under certain
CC conditions, relocalizes to recycling endosomes and to the inner nuclear
CC membrane. {ECO:0000250|UniProtKB:O54965}.
CC -!- DOMAIN: The RING-type zinc finger domain is required for E3 ligase
CC activity and for promoting ER stress-induced JNK activation and
CC apoptosis. {ECO:0000250|UniProtKB:O43567}.
CC -!- PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:O43567}.
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DR EMBL; BC119833; AAI19834.1; -; mRNA.
DR RefSeq; NP_001069610.1; NM_001076142.1.
DR AlphaFoldDB; Q0VD51; -.
DR SMR; Q0VD51; -.
DR STRING; 9913.ENSBTAP00000014803; -.
DR PaxDb; Q0VD51; -.
DR PRIDE; Q0VD51; -.
DR Ensembl; ENSBTAT00000014803; ENSBTAP00000014803; ENSBTAG00000011147.
DR Ensembl; ENSBTAT00000067782; ENSBTAP00000070592; ENSBTAG00000011147.
DR GeneID; 539035; -.
DR KEGG; bta:539035; -.
DR CTD; 11342; -.
DR VEuPathDB; HostDB:ENSBTAG00000011147; -.
DR VGNC; VGNC:34020; RNF13.
DR eggNOG; KOG4628; Eukaryota.
DR GeneTree; ENSGT00940000154942; -.
DR HOGENOM; CLU_035275_1_1_1; -.
DR InParanoid; Q0VD51; -.
DR OMA; FMIVRCI; -.
DR OrthoDB; 1487241at2759; -.
DR TreeFam; TF317486; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000011147; Expressed in midbrain and 104 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0008432; F:JUN kinase binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
DR GO; GO:0051640; P:organelle localization; IEA:Ensembl.
DR GO; GO:0070304; P:positive regulation of stress-activated protein kinase signaling cascade; ISS:UniProtKB.
DR GO; GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd02123; PA_C_RZF_like; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR044744; ZNRF4/RNF13/RNF167_PA.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Endosome; Glycoprotein; Lysosome; Membrane;
KW Metal-binding; Nucleus; Reference proteome; Signal; Transferase;
KW Transmembrane; Transmembrane helix; Ubl conjugation;
KW Ubl conjugation pathway; Zinc; Zinc-finger.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..380
FT /note="E3 ubiquitin-protein ligase RNF13"
FT /id="PRO_0000307367"
FT TOPO_DOM 35..182
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..380
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 65..160
FT /note="PA"
FT ZN_FING 240..282
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 285..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 380 AA; 42688 MW; F059487ACA561F5E CRC64;
MLLSIGMLML SATQVYTILT VQLFAFLNLL PVEADILAYN FENASQTFDD LPARFGYRLP
AEGLKGFLIN SKPENACEPI VPPPVRDNSS GTFIVLIRRL DCNFDEKVLN AQRAGYKAAI
VHNVDSDDLI SMGSNDIEVL KKIDIPSVFI GESSANSLKD EFTYEKGGHI ILVPEFSLPL
EYYLIPFLII VGICLILIVI FMITKFVQDR HRARRNRLRK DQLKKLPVHK FKKGDEYDVC
AICLDEYEDG DKLRILPCSH AYHCKCVDPW LTKTKKTCPV CKQKVVPSQG DSDSDTDSSQ
EENEVSEHTP LLRPLASAST QSFGALSESR SHQNMTESSD YEEDDNDTDS SDAENEINEH
SVVVQLQPNG ERDYNIANTV
