RNF17_MACFA
ID RNF17_MACFA Reviewed; 1534 AA.
AC Q4R3G4; Q4R7C4; Q4R8D9; Q95LZ6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=RING finger protein 17;
GN Name=RNF17; ORFNames=QtsA-12695, QtsA-12850, QtsA-15623, QtsA-17057;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 961-1534 (ISOFORM 4).
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1440 (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
CC -!- FUNCTION: Seems to be involved in regulation of transcriptional
CC activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX
CC heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3,
CC MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with MXD1, MXD3, MXD4, MXI1 and PIWIL1. Self-
CC associates.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Predominantly found in the cytoplasm. Component of a nuage in male
CC germ cells (an electron-dense spherical cytoplasmic body present in
CC late pachytene and diplotene spermatocytes and in elonging spermatids)
CC (By similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q4R3G4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4R3G4-2; Sequence=VSP_033083;
CC Name=3;
CC IsoId=Q4R3G4-3; Sequence=VSP_033082;
CC Name=4;
CC IsoId=Q4R3G4-4; Sequence=VSP_033086;
CC Name=5;
CC IsoId=Q4R3G4-5; Sequence=VSP_033084, VSP_033085;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB64438.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAE00633.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB168896; BAE00998.1; -; mRNA.
DR EMBL; AB179302; BAE02353.1; -; mRNA.
DR EMBL; AB168514; BAE00633.1; ALT_INIT; mRNA.
DR EMBL; AB071045; BAB64438.1; ALT_SEQ; mRNA.
DR AlphaFoldDB; Q4R3G4; -.
DR SMR; Q4R3G4; -.
DR STRING; 9541.XP_005585549.1; -.
DR eggNOG; KOG2039; Eukaryota.
DR eggNOG; KOG2279; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd04508; TUDOR; 4.
DR Gene3D; 2.40.50.90; -; 4.
DR InterPro; IPR039117; RNF17.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR16442; PTHR16442; 1.
DR Pfam; PF00567; TUDOR; 5.
DR SMART; SM00333; TUDOR; 4.
DR SUPFAM; SSF50199; SSF50199; 1.
DR PROSITE; PS50304; TUDOR; 4.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Developmental protein; Differentiation;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Spermatogenesis; Zinc;
KW Zinc-finger.
FT CHAIN 1..1534
FT /note="RING finger protein 17"
FT /id="PRO_0000330758"
FT DOMAIN 637..695
FT /note="Tudor 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 873..932
FT /note="Tudor 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 1139..1196
FT /note="Tudor 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 1390..1450
FT /note="Tudor 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT ZN_FING 32..75
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1352..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..587
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_033082"
FT VAR_SEQ 1..88
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_033083"
FT VAR_SEQ 207..364
FT /note="KYNNKKGLSCYDTYPPLEKKKVDMSVVTNEAPPPPLQPETNDVHLEAKIFQP
FT QKDVVATASSKTIAVLPQMGSSPDVIIEEIIEDNMETCSTDDLGETPRYPKKPLQKNSS
FT VPFGSKAGSAELVFVSHVIDPCHFYIRKYSQIKDAKVLEKKVNEFCN -> NLCEEFAR
FT TTDDYLSNLIKAKSYIEEKKNNLNAAMNIARALQLSPSLRMYCDLKQIIRTLKLTSDSE
FT LAQVSSPKLRNPPRLSVNCSEIICMFNNMGKIEFGDSAKCYPQENEIRQNIQKKYNNKK
FT GLSCYDTYPSSVFLVSSIIPHLLGMSGNQMQ (in isoform 5)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_033084"
FT VAR_SEQ 365..1534
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_033085"
FT VAR_SEQ 1275..1299
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_033086"
FT CONFLICT 674
FT /note="F -> S (in Ref. 2; BAB64438)"
FT /evidence="ECO:0000305"
FT CONFLICT 976..979
FT /note="Missing (in Ref. 1; BAE00633)"
FT /evidence="ECO:0000305"
FT CONFLICT 1199
FT /note="C -> R (in Ref. 1; BAE02353)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1534 AA; 174145 MW; C750A65D68AB9D17 CRC64;
MAAEPSKTGP SRSAYQRMGR KSQHWGAADI QCTRCGRRVS RASGHHCELQ CGHAFCELCL
LMTEECTTIV CPDCEVATAV NTRQGCYAMA GYVKEDSVME KRQPKTIKNC SQDFKKTADQ
LTTGLERSAS THRTVLNSSS VMLDTNTAEE IDEALTTAHH NFEQLSIAGK ALEHMQKQTI
EERERVTEVV EKQFDQLLAF FDSRKKKYNN KKGLSCYDTY PPLEKKKVDM SVVTNEAPPP
PLQPETNDVH LEAKIFQPQK DVVATASSKT IAVLPQMGSS PDVIIEEIIE DNMETCSTDD
LGETPRYPKK PLQKNSSVPF GSKAGSAELV FVSHVIDPCH FYIRKYSQIK DAKVLEKKVN
EFCNRSSHLD PSDILELGAR IFVNSIKNGM WCRGTITELI PIEGKNTRKP CSPTRLFVHE
VALIQIFMVD FGNSEVLIVT GVVDTHVRPE HSAKQHIALN DLCLILRKSE PYIEGLLKDI
QPLAQPCSLK DIVPQNSNEG WEEEAKVEFL KMVNNKAVSM KVFREEDGVL IVDLQKPPPN
KISSDMPVSL RDALVFMELA KFKSQSLRSH FEKNTTLHYH PPILPKEMTD VSVTVCHINS
PGDFYLQLIE GLDFLFLLKT IEEFYKNEAG ENLEILCPVQ DQVCVAKFED GIWYRAKVIG
LPGHQEVEVK YVDFGNTAKI TIKDVRKIKD EFLTAPEKAI KCKLAYIEPY KRTMQWSKEA
KEKFEDKAQD KFMTCSIIKI LEDNVLLVEL FDSLGVPEMT TTSINDQLVK EGLASYEIGY
ILKDNSQKHI EVWDPSPEEI ISNEVHNLNP VSAKSLPNEN FQSLYNKELP VHICNVISPE
KIYVQWLLTE NLLNSLEEKM IAAYENSKWE PVKWENDMHC AVKIQDKNQW RRGQIIRMVT
DTLVEVLLYD VGVELVVNVD CLRKLQENLK TMGRLSLECS LVDIRPAGGS DKWTATACDC
LSLYLTGAVA TIILQVDSEE NNTTWPLPVK IFCRDEKGER VDVSKYLIKK GLALRERRIN
KLDNSHSLSE KSLEVPLEQE DSVVTNCIKT NFDPDKKTAD IISEQKVSEF QEEILEPRTA
RGYKPPAIPN MKVFEATVSC VGDDGTIFVV PKLSEFELIK MTNEIQSNLK CLGLLEPYFW
KKGEACAVRG SDTLWYRGKV MEVVGGAVRV QYLDHGFTEK IPQCHLYPIL LYPDIPQFCI
PCQLHNTTPV GNVWQPDAIE VLQQLLSKRE VDIHIMELPK NPWEKLSIHL YFDGMSLSYF
MAYYKYCTSE HTEEMLKEKP RSDHDRKYEE EQWEIRFEEL LSSETDTPLL PPYLSSSLPS
PGELCAVQVK HVVSPNEVYI CLDSIETCNH SNQHSDTDDS GVSGESESES LDEALQRVNK
KVEALPPLTD FRTEMPCLAE YDDGLWYRAK IVSIKEFNPL SILVQFVDYG STAKLTLNRL
CQIPPHLMRY PARAIKVLLA GFKPPLRDLG ETRIPYCPKW SMEALWAMID CLQGKQLYAV
SMAPAPEQIV TLYDEEQHPV HMPLVEMGLA DKDE
