RNF24_HUMAN
ID RNF24_HUMAN Reviewed; 148 AA.
AC Q9Y225; D3DVZ2; D3DVZ3; Q9UMH1;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=RING finger protein 24;
GN Name=RNF24;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Stavrides G.S., Huckle E.J., Deloukas P.;
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Blood, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-148.
RG The European IMAGE consortium;
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP FUNCTION, INTERACTION WITH TRPC1; TRPC3; TRPC4; TRPC5; TRPC6 AND TRPC7, AND
RP SUBCELLULAR LOCATION.
RX PubMed=17850865; DOI=10.1016/j.ceca.2007.07.009;
RA Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.;
RT "RNF24, a new TRPC interacting protein, causes the intracellular retention
RT of TRPC.";
RL Cell Calcium 43:432-443(2008).
RN [8]
RP STRUCTURE BY NMR OF 68-128 IN COMPLEX WITH ZINC.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of RING finger from human RING finger protein 24.";
RL Submitted (FEB-2009) to the PDB data bank.
CC -!- FUNCTION: May play a role in TRPCs intracellular trafficking.
CC {ECO:0000269|PubMed:17850865}.
CC -!- SUBUNIT: Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.
CC {ECO:0000269|PubMed:17850865, ECO:0000269|Ref.8}.
CC -!- INTERACTION:
CC Q9Y225; P07919: UQCRH; NbExp=3; IntAct=EBI-10195462, EBI-1224427;
CC Q9Y225-2; Q8WTS1: ABHD5; NbExp=3; IntAct=EBI-13044680, EBI-2813554;
CC Q9Y225-2; Q9NVT9: ARMC1; NbExp=3; IntAct=EBI-13044680, EBI-3506974;
CC Q9Y225-2; Q12983: BNIP3; NbExp=3; IntAct=EBI-13044680, EBI-749464;
CC Q9Y225-2; O95406: CNIH1; NbExp=3; IntAct=EBI-13044680, EBI-12172273;
CC Q9Y225-2; Q6ZVE7: GOLT1A; NbExp=3; IntAct=EBI-13044680, EBI-17231387;
CC Q9Y225-2; Q86UP9: LHFPL3; NbExp=3; IntAct=EBI-13044680, EBI-12925734;
CC Q9Y225-2; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-13044680, EBI-373355;
CC Q9Y225-2; Q16617: NKG7; NbExp=3; IntAct=EBI-13044680, EBI-3919611;
CC Q9Y225-2; Q8IZ57: NRSN1; NbExp=3; IntAct=EBI-13044680, EBI-10264528;
CC Q9Y225-2; P21589: NT5E; NbExp=3; IntAct=EBI-13044680, EBI-6393623;
CC Q9Y225-2; P60201-2: PLP1; NbExp=3; IntAct=EBI-13044680, EBI-12188331;
CC Q9Y225-2; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-13044680, EBI-18159983;
CC Q9Y225-2; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-13044680, EBI-6268651;
CC Q9Y225-2; Q9Y320: TMX2; NbExp=3; IntAct=EBI-13044680, EBI-6447886;
CC Q9Y225-2; P23763-3: VAMP1; NbExp=3; IntAct=EBI-13044680, EBI-12097582;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:17850865}; Single-pass membrane protein
CC {ECO:0000269|PubMed:17850865}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y225-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y225-2; Sequence=VSP_041026;
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DR EMBL; AL096778; CAB46627.1; -; mRNA.
DR EMBL; BT007406; AAP36074.1; -; mRNA.
DR EMBL; AL031670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10467.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10468.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10469.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10471.1; -; Genomic_DNA.
DR EMBL; BC000213; AAH00213.1; -; mRNA.
DR EMBL; BC039584; AAH39584.1; -; mRNA.
DR EMBL; AL079313; CAB45279.1; -; mRNA.
DR CCDS; CCDS13074.1; -. [Q9Y225-1]
DR CCDS; CCDS46577.1; -. [Q9Y225-2]
DR RefSeq; NP_001127809.1; NM_001134337.2. [Q9Y225-1]
DR RefSeq; NP_001127810.1; NM_001134338.2. [Q9Y225-2]
DR RefSeq; NP_001308678.1; NM_001321749.1. [Q9Y225-1]
DR RefSeq; NP_009150.1; NM_007219.4. [Q9Y225-1]
DR RefSeq; XP_011527447.1; XM_011529145.2. [Q9Y225-2]
DR RefSeq; XP_016883109.1; XM_017027620.1. [Q9Y225-2]
DR RefSeq; XP_016883110.1; XM_017027621.1. [Q9Y225-2]
DR PDB; 2EP4; NMR; -; A=68-128.
DR PDBsum; 2EP4; -.
DR AlphaFoldDB; Q9Y225; -.
DR SMR; Q9Y225; -.
DR BioGRID; 116402; 18.
DR IntAct; Q9Y225; 16.
DR STRING; 9606.ENSP00000388550; -.
DR iPTMnet; Q9Y225; -.
DR PhosphoSitePlus; Q9Y225; -.
DR BioMuta; RNF24; -.
DR DMDM; 20139860; -.
DR jPOST; Q9Y225; -.
DR MassIVE; Q9Y225; -.
DR MaxQB; Q9Y225; -.
DR PaxDb; Q9Y225; -.
DR PeptideAtlas; Q9Y225; -.
DR PRIDE; Q9Y225; -.
DR ProteomicsDB; 85610; -. [Q9Y225-1]
DR ProteomicsDB; 85611; -. [Q9Y225-2]
DR Antibodypedia; 23773; 117 antibodies from 19 providers.
DR DNASU; 11237; -.
DR Ensembl; ENST00000336095.10; ENSP00000336753.5; ENSG00000101236.17. [Q9Y225-1]
DR Ensembl; ENST00000358395.11; ENSP00000351166.6; ENSG00000101236.17. [Q9Y225-1]
DR Ensembl; ENST00000432261.6; ENSP00000388550.2; ENSG00000101236.17. [Q9Y225-2]
DR Ensembl; ENST00000545616.2; ENSP00000444711.1; ENSG00000101236.17. [Q9Y225-2]
DR GeneID; 11237; -.
DR KEGG; hsa:11237; -.
DR MANE-Select; ENST00000358395.11; ENSP00000351166.6; NM_001134337.3; NP_001127809.1.
DR UCSC; uc002wkh.4; human. [Q9Y225-1]
DR CTD; 11237; -.
DR DisGeNET; 11237; -.
DR GeneCards; RNF24; -.
DR HGNC; HGNC:13779; RNF24.
DR HPA; ENSG00000101236; Tissue enhanced (bone).
DR MIM; 612489; gene.
DR neXtProt; NX_Q9Y225; -.
DR OpenTargets; ENSG00000101236; -.
DR PharmGKB; PA34428; -.
DR VEuPathDB; HostDB:ENSG00000101236; -.
DR eggNOG; KOG0800; Eukaryota.
DR GeneTree; ENSGT00940000159443; -.
DR HOGENOM; CLU_142341_0_0_1; -.
DR InParanoid; Q9Y225; -.
DR OMA; HSKQDPG; -.
DR OrthoDB; 1625209at2759; -.
DR PhylomeDB; Q9Y225; -.
DR PathwayCommons; Q9Y225; -.
DR SignaLink; Q9Y225; -.
DR BioGRID-ORCS; 11237; 31 hits in 1118 CRISPR screens.
DR ChiTaRS; RNF24; human.
DR EvolutionaryTrace; Q9Y225; -.
DR GeneWiki; RNF24; -.
DR GenomeRNAi; 11237; -.
DR Pharos; Q9Y225; Tbio.
DR PRO; PR:Q9Y225; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9Y225; protein.
DR Bgee; ENSG00000101236; Expressed in secondary oocyte and 180 other tissues.
DR Genevisible; Q9Y225; HS.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR040098; RNF24.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR011016; Znf_RING-CH.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22763:SF21; PTHR22763:SF21; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00744; RINGv; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Golgi apparatus; Membrane;
KW Metal-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW Zinc; Zinc-finger.
FT CHAIN 1..148
FT /note="RING finger protein 24"
FT /id="PRO_0000056063"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 78..119
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT VAR_SEQ 1
FT /note="M -> MLNKSGESRYPALFPVLGGSSM (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_041026"
FT CONFLICT 45
FT /note="Y -> S (in Ref. 6; CAB45279)"
FT /evidence="ECO:0000305"
FT STRAND 79..81
FT /evidence="ECO:0007829|PDB:2EP4"
FT STRAND 87..89
FT /evidence="ECO:0007829|PDB:2EP4"
FT STRAND 91..94
FT /evidence="ECO:0007829|PDB:2EP4"
FT TURN 95..97
FT /evidence="ECO:0007829|PDB:2EP4"
FT STRAND 98..101
FT /evidence="ECO:0007829|PDB:2EP4"
FT HELIX 102..111
FT /evidence="ECO:0007829|PDB:2EP4"
FT TURN 116..118
FT /evidence="ECO:0007829|PDB:2EP4"
SQ SEQUENCE 148 AA; 17210 MW; 66C240C3A5991EA5 CRC64;
MSSDFPHYNF RMPNIGFQNL PLNIYIVVFG TAIFVFILSL LFCCYLIRLR HQAHKEFYAY
KQVILKEKVK ELNLHELCAV CLEDFKPRDE LGICPCKHAF HRKCLIKWLE VRKVCPLCNM
PVLQLAQLHS KQDRGPPQGP LPGAENIV
