RNF24_MOUSE
ID RNF24_MOUSE Reviewed; 148 AA.
AC Q8BGI1;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=RING finger protein 24;
GN Name=Rnf24;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Cerebellum, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May play a role in TRPCs intracellular trafficking.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass membrane protein {ECO:0000250}.
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DR EMBL; AK048813; BAC33467.1; -; mRNA.
DR EMBL; AK083665; BAC38987.1; -; mRNA.
DR EMBL; AK089207; BAC40793.1; -; mRNA.
DR CCDS; CCDS16762.1; -.
DR RefSeq; NP_848722.1; NM_178607.4.
DR AlphaFoldDB; Q8BGI1; -.
DR SMR; Q8BGI1; -.
DR STRING; 10090.ENSMUSP00000058630; -.
DR iPTMnet; Q8BGI1; -.
DR PhosphoSitePlus; Q8BGI1; -.
DR SwissPalm; Q8BGI1; -.
DR MaxQB; Q8BGI1; -.
DR PaxDb; Q8BGI1; -.
DR PRIDE; Q8BGI1; -.
DR ProteomicsDB; 300499; -.
DR Antibodypedia; 23773; 117 antibodies from 19 providers.
DR DNASU; 51902; -.
DR Ensembl; ENSMUST00000059372; ENSMUSP00000058630; ENSMUSG00000048911.
DR Ensembl; ENSMUST00000110194; ENSMUSP00000105823; ENSMUSG00000048911.
DR Ensembl; ENSMUST00000165420; ENSMUSP00000129843; ENSMUSG00000048911.
DR GeneID; 51902; -.
DR KEGG; mmu:51902; -.
DR UCSC; uc008mlk.2; mouse.
DR CTD; 11237; -.
DR MGI; MGI:1261771; Rnf24.
DR VEuPathDB; HostDB:ENSMUSG00000048911; -.
DR eggNOG; KOG0800; Eukaryota.
DR GeneTree; ENSGT00940000159443; -.
DR HOGENOM; CLU_142341_0_0_1; -.
DR InParanoid; Q8BGI1; -.
DR OMA; HSKQDPG; -.
DR OrthoDB; 1625209at2759; -.
DR PhylomeDB; Q8BGI1; -.
DR BioGRID-ORCS; 51902; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Rnf24; mouse.
DR PRO; PR:Q8BGI1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BGI1; protein.
DR Bgee; ENSMUSG00000048911; Expressed in animal zygote and 206 other tissues.
DR ExpressionAtlas; Q8BGI1; baseline and differential.
DR Genevisible; Q8BGI1; MM.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR040098; RNF24.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR011016; Znf_RING-CH.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22763:SF21; PTHR22763:SF21; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00744; RINGv; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Metal-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..148
FT /note="RING finger protein 24"
FT /id="PRO_0000056064"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 78..119
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ SEQUENCE 148 AA; 17254 MW; 96DFD3E31B6CC5C8 CRC64;
MSSDFPHYNF RMPNIGFQNL PLNIYIVVFG TAVFVFILSL LFCCYLIRLR HQAHKEFYAY
KQVILKEKVK ELNLHELCAV CLEDFKPRDE LGICPCKHAF HRKCLVKWLE VRKVCPLCNM
PVLQLAQLHS KQDRGPPQEP LPGAENIV
