RNF38_HUMAN
ID RNF38_HUMAN Reviewed; 515 AA.
AC Q9H0F5; A6PVP9; B1AM81; B1AM82; B3KSG4; E7EVL3; Q7LB33; Q8N0Y0; Q9H748;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 4.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=E3 ubiquitin-protein ligase RNF38 {ECO:0000305};
DE EC=2.3.2.27;
DE AltName: Full=RING finger protein 38;
DE AltName: Full=RING-type E3 ubiquitin transferase RNF38 {ECO:0000305};
GN Name=RNF38 {ECO:0000312|HGNC:HGNC:18052};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, AND VARIANT
RP THR-206.
RX PubMed=12074600; DOI=10.1016/s0006-291x(02)00584-3;
RA Eisenberg I., Hochner H., Levi T., Yelin R., Kahan T.,
RA Mitrani-Rosenbaum S.;
RT "Cloning and characterization of a novel human gene RNF38 encoding a
RT conserved putative protein with a RING finger domain.";
RL Biochem. Biophys. Res. Commun. 294:1169-1176(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
RC TISSUE=Colon, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION, NUCLEAR LOCALIZATION SIGNAL, AND SUBCELLULAR LOCATION.
RX PubMed=23973461; DOI=10.1016/j.bbrc.2013.08.031;
RA Sheren J.E., Kassenbrock C.K.;
RT "RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53.";
RL Biochem. Biophys. Res. Commun. 440:473-478(2013).
RN [8]
RP STRUCTURE BY NMR OF 445-506.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of RING finger in RING finger protein 38.";
RL Submitted (NOV-2005) to the PDB data bank.
CC -!- FUNCTION: Acts as an E3 ubiquitin-protein ligase able to ubiquitinate
CC p53/TP53 which promotes its relocalization to discrete foci associated
CC with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.
CC {ECO:0000269|PubMed:23973461}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27;
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- INTERACTION:
CC Q9H0F5; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-2341200, EBI-3867333;
CC Q9H0F5; Q5T749: KPRP; NbExp=3; IntAct=EBI-2341200, EBI-10981970;
CC Q9H0F5; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-2341200, EBI-10171774;
CC Q9H0F5; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-2341200, EBI-1052037;
CC Q9H0F5; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-2341200, EBI-1048945;
CC Q9H0F5; Q3LI59: KRTAP21-2; NbExp=3; IntAct=EBI-2341200, EBI-18395721;
CC Q9H0F5; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-2341200, EBI-11962084;
CC Q9H0F5; Q8IUC3: KRTAP7-1; NbExp=3; IntAct=EBI-2341200, EBI-18394498;
CC Q9H0F5; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-2341200, EBI-10261141;
CC Q9H0F5; Q14847-2: LASP1; NbExp=3; IntAct=EBI-2341200, EBI-9088686;
CC Q9H0F5; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-2341200, EBI-12813389;
CC Q9H0F5; Q9H0X6: RNF208; NbExp=3; IntAct=EBI-2341200, EBI-751555;
CC Q9H0F5-2; P54253: ATXN1; NbExp=6; IntAct=EBI-25866807, EBI-930964;
CC Q9H0F5-2; P48643: CCT5; NbExp=3; IntAct=EBI-25866807, EBI-355710;
CC Q9H0F5-2; P42858: HTT; NbExp=21; IntAct=EBI-25866807, EBI-466029;
CC Q9H0F5-2; O76024: WFS1; NbExp=3; IntAct=EBI-25866807, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23973461}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q9H0F5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H0F5-2; Sequence=VSP_012243;
CC Name=3;
CC IsoId=Q9H0F5-3; Sequence=VSP_037337;
CC Name=4;
CC IsoId=Q9H0F5-4; Sequence=VSP_053846, VSP_053847;
CC Name=5;
CC IsoId=Q9H0F5-5; Sequence=VSP_053845;
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in testis.
CC {ECO:0000269|PubMed:12074600}.
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DR EMBL; AF394047; AAM73697.1; -; mRNA.
DR EMBL; AL136817; CAB66751.3; -; mRNA.
DR EMBL; AK024996; BAB15050.1; -; mRNA.
DR EMBL; AK093480; BAG52726.1; -; mRNA.
DR EMBL; AL161792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL354935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471071; EAW58305.1; -; Genomic_DNA.
DR EMBL; BC033786; AAH33786.2; -; mRNA.
DR CCDS; CCDS6603.1; -. [Q9H0F5-1]
DR CCDS; CCDS6604.1; -. [Q9H0F5-2]
DR RefSeq; NP_073618.3; NM_022781.4. [Q9H0F5-1]
DR RefSeq; NP_919309.1; NM_194328.2. [Q9H0F5-3]
DR RefSeq; NP_919310.1; NM_194329.2. [Q9H0F5-2]
DR RefSeq; NP_919311.1; NM_194330.2. [Q9H0F5-3]
DR RefSeq; NP_919313.1; NM_194332.2. [Q9H0F5-3]
DR RefSeq; XP_005251423.1; XM_005251366.3. [Q9H0F5-3]
DR RefSeq; XP_005251424.1; XM_005251367.3. [Q9H0F5-3]
DR RefSeq; XP_005251425.1; XM_005251368.3.
DR RefSeq; XP_006716784.1; XM_006716721.3. [Q9H0F5-3]
DR RefSeq; XP_011516014.1; XM_011517712.2. [Q9H0F5-3]
DR RefSeq; XP_011516015.1; XM_011517713.2. [Q9H0F5-3]
DR RefSeq; XP_016869784.1; XM_017014295.1.
DR PDB; 1X4J; NMR; -; A=445-506.
DR PDB; 4V3K; X-ray; 2.04 A; C/F=439-515.
DR PDB; 4V3L; X-ray; 1.53 A; C=439-515.
DR PDB; 7OJX; X-ray; 2.40 A; A=439-515.
DR PDBsum; 1X4J; -.
DR PDBsum; 4V3K; -.
DR PDBsum; 4V3L; -.
DR PDBsum; 7OJX; -.
DR AlphaFoldDB; Q9H0F5; -.
DR SMR; Q9H0F5; -.
DR BioGRID; 127416; 39.
DR IntAct; Q9H0F5; 30.
DR MINT; Q9H0F5; -.
DR STRING; 9606.ENSP00000259605; -.
DR iPTMnet; Q9H0F5; -.
DR PhosphoSitePlus; Q9H0F5; -.
DR BioMuta; RNF38; -.
DR DMDM; 56749664; -.
DR PaxDb; Q9H0F5; -.
DR PeptideAtlas; Q9H0F5; -.
DR PRIDE; Q9H0F5; -.
DR ProteomicsDB; 3188; -.
DR ProteomicsDB; 80269; -. [Q9H0F5-1]
DR ProteomicsDB; 80270; -. [Q9H0F5-2]
DR ProteomicsDB; 80271; -. [Q9H0F5-3]
DR Antibodypedia; 2887; 89 antibodies from 21 providers.
DR DNASU; 152006; -.
DR Ensembl; ENST00000259605.11; ENSP00000259605.6; ENSG00000137075.18. [Q9H0F5-1]
DR Ensembl; ENST00000350199.8; ENSP00000343947.4; ENSG00000137075.18. [Q9H0F5-3]
DR Ensembl; ENST00000353739.8; ENSP00000335239.5; ENSG00000137075.18. [Q9H0F5-2]
DR Ensembl; ENST00000357058.7; ENSP00000349566.3; ENSG00000137075.18. [Q9H0F5-3]
DR Ensembl; ENST00000377877.4; ENSP00000367109.3; ENSG00000137075.18. [Q9H0F5-4]
DR Ensembl; ENST00000377885.6; ENSP00000367117.2; ENSG00000137075.18. [Q9H0F5-3]
DR Ensembl; ENST00000611646.4; ENSP00000483536.1; ENSG00000137075.18. [Q9H0F5-4]
DR GeneID; 152006; -.
DR KEGG; hsa:152006; -.
DR MANE-Select; ENST00000259605.11; ENSP00000259605.6; NM_022781.5; NP_073618.3.
DR UCSC; uc003zzh.5; human. [Q9H0F5-1]
DR CTD; 152006; -.
DR DisGeNET; 152006; -.
DR GeneCards; RNF38; -.
DR HGNC; HGNC:18052; RNF38.
DR HPA; ENSG00000137075; Low tissue specificity.
DR MIM; 612488; gene.
DR neXtProt; NX_Q9H0F5; -.
DR OpenTargets; ENSG00000137075; -.
DR PharmGKB; PA34438; -.
DR VEuPathDB; HostDB:ENSG00000137075; -.
DR eggNOG; KOG0800; Eukaryota.
DR GeneTree; ENSGT00940000156228; -.
DR HOGENOM; CLU_024578_0_0_1; -.
DR InParanoid; Q9H0F5; -.
DR OMA; PPMIQAC; -.
DR OrthoDB; 1570520at2759; -.
DR PhylomeDB; Q9H0F5; -.
DR TreeFam; TF325756; -.
DR PathwayCommons; Q9H0F5; -.
DR SignaLink; Q9H0F5; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 152006; 9 hits in 1114 CRISPR screens.
DR ChiTaRS; RNF38; human.
DR EvolutionaryTrace; Q9H0F5; -.
DR GeneWiki; RNF38; -.
DR GenomeRNAi; 152006; -.
DR Pharos; Q9H0F5; Tbio.
DR PRO; PR:Q9H0F5; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9H0F5; protein.
DR Bgee; ENSG00000137075; Expressed in sperm and 207 other tissues.
DR Genevisible; Q9H0F5; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IDA:FlyBase.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IDA:FlyBase.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Metal-binding; Nucleus;
KW Reference proteome; Transferase; Ubl conjugation pathway; Zinc;
KW Zinc-finger.
FT CHAIN 1..515
FT /note="E3 ubiquitin-protein ligase RNF38"
FT /id="PRO_0000056078"
FT ZN_FING 463..504
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 73..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 57..71
FT /note="Bipartite nuclear localization signal 1"
FT MOTIF 115..131
FT /note="Bipartite nuclear localization signal 2"
FT COMPBIAS 87..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..183
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053845"
FT VAR_SEQ 1..83
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12074600"
FT /id="VSP_037337"
FT VAR_SEQ 1..44
FT /note="MACKISPGANSASLPGHPNKVICERVRLQSLFPLLPSDQNTTVQ -> MQHT
FT CTQQKKVTYKHIARFSPRNRLCQADAVFNNNLAGFQLQSP (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053846"
FT VAR_SEQ 5..54
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_012243"
FT VAR_SEQ 45..120
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053847"
FT VARIANT 206
FT /note="A -> T (in dbSNP:rs183475137)"
FT /evidence="ECO:0000269|PubMed:12074600"
FT /id="VAR_055400"
FT CONFLICT 308
FT /note="I -> K (in Ref. 2; CAB66751)"
FT /evidence="ECO:0000305"
FT CONFLICT 421
FT /note="E -> G (in Ref. 3; BAG52726)"
FT /evidence="ECO:0000305"
FT HELIX 441..445
FT /evidence="ECO:0007829|PDB:4V3K"
FT STRAND 448..450
FT /evidence="ECO:0007829|PDB:4V3L"
FT STRAND 453..455
FT /evidence="ECO:0007829|PDB:1X4J"
FT STRAND 457..459
FT /evidence="ECO:0007829|PDB:4V3L"
FT TURN 464..467
FT /evidence="ECO:0007829|PDB:4V3L"
FT STRAND 475..478
FT /evidence="ECO:0007829|PDB:4V3L"
FT TURN 480..482
FT /evidence="ECO:0007829|PDB:1X4J"
FT STRAND 484..486
FT /evidence="ECO:0007829|PDB:4V3L"
FT HELIX 487..496
FT /evidence="ECO:0007829|PDB:4V3L"
FT TURN 501..503
FT /evidence="ECO:0007829|PDB:4V3L"
SQ SEQUENCE 515 AA; 57595 MW; ABFE9486CA732AFA CRC64;
MACKISPGAN SASLPGHPNK VICERVRLQS LFPLLPSDQN TTVQEDAHFK AFFQSEDSPS
PKRQRLSHSV FDYTSASPAP SPPMRPWEMT SNRQPPSVRP SQHHFSGERC NTPARNRRSP
PVRRQRGRRD RLSRHNSISQ DENYHHLPYA QQQAIEEPRA FHPPNVSPRL LHPAAHPPQQ
NAVMVDIHDQ LHQGTVPVSY TVTTVAPHGI PLCTGQHIPA CSTQQVPGCS VVFSGQHLPV
CSVPPPMLQA CSVQHLPVPY AAFPPLISSD PFLIHPPHLS PHHPPHLPPP GQFVPFQTQQ
SRSPLQRIEN EVELLGEHLP VGGFTYPPSA HPPTLPPSAP LQFLTHDPLH QEVSFGVPYP
PFMPRRLTGR SRYRSQQPIP PPPYHPSLLP YVLSMLPVPP AVGPTFSFEL DVEDGEVENY
EALLNLAERL GEAKPRGLTK ADIEQLPSYR FNPNNHQSEQ TLCVVCMCDF ESRQLLRVLP
CNHEFHAKCV DKWLKANRTC PICRADASEV HRDSE