ID   RNF41_DANRE             Reviewed;         318 AA.
AC   Q7ZW16;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=E3 ubiquitin-protein ligase NRDP1;
DE            EC=2.3.2.27;
DE   AltName: Full=RING finger protein 41;
DE   AltName: Full=RING-type E3 ubiquitin transferase NRDP1 {ECO:0000305};
GN   Name=rnf41; Synonyms=nrdp1; ORFNames=zgc:55389;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as E3 ubiquitin-protein ligase and regulates the
CC       degradation of target proteins. {ECO:0000250|UniProtKB:Q9H4P4}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27;
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
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DR   EMBL; BC045329; AAH45329.1; -; mRNA.
DR   RefSeq; NP_998681.1; NM_213516.1.
DR   AlphaFoldDB; Q7ZW16; -.
DR   SMR; Q7ZW16; -.
DR   STRING; 7955.ENSDARP00000053471; -.
DR   PaxDb; Q7ZW16; -.
DR   GeneID; 406837; -.
DR   KEGG; dre:406837; -.
DR   CTD; 10193; -.
DR   ZFIN; ZDB-GENE-040426-2920; rnf41.
DR   eggNOG; KOG0297; Eukaryota.
DR   InParanoid; Q7ZW16; -.
DR   OrthoDB; 918518at2759; -.
DR   PhylomeDB; Q7ZW16; -.
DR   Reactome; R-DRE-1358803; Downregulation of ERBB2:ERBB3 signaling.
DR   Reactome; R-DRE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q7ZW16; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0071782; C:endoplasmic reticulum tubular network; IBA:GO_Central.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0030318; P:melanocyte differentiation; IMP:ZFIN.
DR   GO; GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 2.
DR   InterPro; IPR015036; NRDP1.
DR   InterPro; IPR037255; NRDP1_C.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   InterPro; IPR013010; Znf_SIAH.
DR   Pfam; PF08941; USP8_interact; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF160088; SSF160088; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
DR   PROSITE; PS51081; ZF_SIAH; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Transferase; Ubl conjugation pathway;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..318
FT                   /note="E3 ubiquitin-protein ligase NRDP1"
FT                   /id="PRO_0000223956"
FT   ZN_FING         18..57
FT                   /note="RING-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   ZN_FING         78..138
FT                   /note="SIAH-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00455"
SQ   SEQUENCE   318 AA;  36128 MW;  9EE52A3C21B0171E CRC64;
     MGYDVTRFQG EVDEDLLCPI CSGVLEEPVR APHCEHAFCN ACITQWFAQQ QICPVDRTVV
     TLAHLRPVPR IMRNMLSKLQ ISCDNAGFGC TATLRLDQLQ SHLKDCEHNP KRPVTCEEGC
     GLEMPKDEMP NHNCIKHLRS VVQQQQTKIA DLEKTAAEHK HQLAEQKRDI QLLKAYMRAI
     RSANPNLQNL EESIEYNEIL EWVNSLQPAR VTRWGGMIST PDAVLQAVIK RSLIDSGCPL
     SIVNDLIENA HERNWPQGLA TLETRQMNRR YYENYVAKRI PGKQAVVVMA CENQHMGEDM
     ILEPGLVMIF AHGVEEIL