位置:首页 > 蛋白库 > RNF41_XENLA
RNF41_XENLA
ID   RNF41_XENLA             Reviewed;         317 AA.
AC   Q5FWL3;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=E3 ubiquitin-protein ligase NRDP1;
DE            EC=2.3.2.27;
DE   AltName: Full=RING finger protein 41;
DE   AltName: Full=RING-type E3 ubiquitin transferase NRDP1 {ECO:0000305};
GN   Name=rnf41; Synonyms=nrdp1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as E3 ubiquitin-protein ligase and regulates the
CC       degradation of target proteins. {ECO:0000250|UniProtKB:Q9H4P4}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27;
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC089294; AAH89294.1; -; mRNA.
DR   EMBL; BC108758; AAI08759.1; -; mRNA.
DR   RefSeq; NP_001089261.1; NM_001095792.1.
DR   AlphaFoldDB; Q5FWL3; -.
DR   SMR; Q5FWL3; -.
DR   DNASU; 734308; -.
DR   GeneID; 734308; -.
DR   KEGG; xla:734308; -.
DR   CTD; 734308; -.
DR   Xenbase; XB-GENE-943151; rnf41.S.
DR   OMA; SRQPTCP; -.
DR   OrthoDB; 918518at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 734308; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
DR   GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.
DR   Gene3D; 3.30.40.10; -; 2.
DR   InterPro; IPR015036; NRDP1.
DR   InterPro; IPR037255; NRDP1_C.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF08941; USP8_interact; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF160088; SSF160088; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Metal-binding; Reference proteome; Transferase;
KW   Ubl conjugation pathway; Zinc; Zinc-finger.
FT   CHAIN           1..317
FT                   /note="E3 ubiquitin-protein ligase NRDP1"
FT                   /id="PRO_0000223957"
FT   ZN_FING         18..57
FT                   /note="RING-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   COILED          135..175
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   317 AA;  35911 MW;  6C2117534A4E30C1 CRC64;
     MGYDVSRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV
     TVAHLRPVPR IMRNMLSKLQ ITCDNAVFGC TTIVRLDNLM SHLSDCEHNP KRPVTCEQGC
     GLEMPKDEVP NHNCIKHLRS VVQQQQIRIG ELEKTAAESK HQLSEQKRDI QLLKAYMRAI
     RSANPNLQNL EETIEYNEIL EWVNSLQPAR VTRWGGMIST PDAVLQAVIK RSLVESGCPA
     SIVNEIIENA HERNWPQGLA TLETRQMNRR YYENYVAKRI PGKQAVVVMA CENQHMGEDM
     VLEPGLVMIF AHGVEEI
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024