RNF44_HUMAN
ID RNF44_HUMAN Reviewed; 432 AA.
AC Q7L0R7; B4DYE0; Q8ND05; Q9UPQ2;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=RING finger protein 44;
GN Name=RNF44; Synonyms=KIAA1100;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:197-205(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-432 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- INTERACTION:
CC Q7L0R7; Q03989: ARID5A; NbExp=3; IntAct=EBI-2845060, EBI-948603;
CC Q7L0R7; Q15038: DAZAP2; NbExp=3; IntAct=EBI-2845060, EBI-724310;
CC Q7L0R7; Q8IUB9: KRTAP19-1; NbExp=3; IntAct=EBI-2845060, EBI-12811111;
CC Q7L0R7; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-2845060, EBI-1048945;
CC Q7L0R7; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-2845060, EBI-10241353;
CC Q7L0R7; Q3LI59: KRTAP21-2; NbExp=3; IntAct=EBI-2845060, EBI-18395721;
CC Q7L0R7; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-2845060, EBI-9996449;
CC Q7L0R7; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-2845060, EBI-12813389;
CC Q7L0R7; Q96LM6: TEX37; NbExp=3; IntAct=EBI-2845060, EBI-743976;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7L0R7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7L0R7-2; Sequence=VSP_055432;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA83052.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB029023; BAA83052.2; ALT_INIT; mRNA.
DR EMBL; AK302385; BAG63702.1; -; mRNA.
DR EMBL; AC010316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC091934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039833; AAH39833.1; -; mRNA.
DR EMBL; BC063297; AAH63297.1; -; mRNA.
DR EMBL; AL834489; CAD39147.2; -; mRNA.
DR CCDS; CCDS4404.1; -. [Q7L0R7-1]
DR RefSeq; NP_055716.1; NM_014901.4. [Q7L0R7-1]
DR RefSeq; XP_005265897.1; XM_005265840.2. [Q7L0R7-1]
DR RefSeq; XP_005265898.1; XM_005265841.4. [Q7L0R7-1]
DR RefSeq; XP_005265899.1; XM_005265842.4. [Q7L0R7-2]
DR RefSeq; XP_005265900.1; XM_005265843.2. [Q7L0R7-2]
DR RefSeq; XP_005265901.1; XM_005265844.3. [Q7L0R7-2]
DR RefSeq; XP_005265902.1; XM_005265845.4. [Q7L0R7-2]
DR RefSeq; XP_011532768.1; XM_011534466.2. [Q7L0R7-1]
DR RefSeq; XP_011532769.1; XM_011534467.2. [Q7L0R7-2]
DR AlphaFoldDB; Q7L0R7; -.
DR SMR; Q7L0R7; -.
DR BioGRID; 116512; 14.
DR IntAct; Q7L0R7; 10.
DR STRING; 9606.ENSP00000274811; -.
DR iPTMnet; Q7L0R7; -.
DR PhosphoSitePlus; Q7L0R7; -.
DR BioMuta; RNF44; -.
DR DMDM; 74758994; -.
DR MassIVE; Q7L0R7; -.
DR PaxDb; Q7L0R7; -.
DR PeptideAtlas; Q7L0R7; -.
DR PRIDE; Q7L0R7; -.
DR ProteomicsDB; 5519; -.
DR ProteomicsDB; 68736; -. [Q7L0R7-1]
DR Antibodypedia; 45996; 54 antibodies from 11 providers.
DR DNASU; 22838; -.
DR Ensembl; ENST00000274811.9; ENSP00000274811.4; ENSG00000146083.12. [Q7L0R7-1]
DR GeneID; 22838; -.
DR KEGG; hsa:22838; -.
DR MANE-Select; ENST00000274811.9; ENSP00000274811.4; NM_014901.5; NP_055716.1.
DR UCSC; uc003mek.2; human. [Q7L0R7-1]
DR CTD; 22838; -.
DR DisGeNET; 22838; -.
DR GeneCards; RNF44; -.
DR HGNC; HGNC:19180; RNF44.
DR HPA; ENSG00000146083; Low tissue specificity.
DR MIM; 619283; gene.
DR neXtProt; NX_Q7L0R7; -.
DR OpenTargets; ENSG00000146083; -.
DR PharmGKB; PA38819; -.
DR VEuPathDB; HostDB:ENSG00000146083; -.
DR eggNOG; KOG0800; Eukaryota.
DR GeneTree; ENSGT00940000158553; -.
DR HOGENOM; CLU_024578_0_0_1; -.
DR InParanoid; Q7L0R7; -.
DR OMA; QHIPGCN; -.
DR PhylomeDB; Q7L0R7; -.
DR TreeFam; TF325756; -.
DR PathwayCommons; Q7L0R7; -.
DR SignaLink; Q7L0R7; -.
DR BioGRID-ORCS; 22838; 6 hits in 1112 CRISPR screens.
DR ChiTaRS; RNF44; human.
DR GenomeRNAi; 22838; -.
DR Pharos; Q7L0R7; Tdark.
DR PRO; PR:Q7L0R7; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q7L0R7; protein.
DR Bgee; ENSG00000146083; Expressed in granulocyte and 199 other tissues.
DR ExpressionAtlas; Q7L0R7; baseline and differential.
DR Genevisible; Q7L0R7; HS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..432
FT /note="RING finger protein 44"
FT /id="PRO_0000273413"
FT ZN_FING 380..421
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..81
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055432"
SQ SEQUENCE 432 AA; 47728 MW; D6C2938B18A66816 CRC64;
MRPWALAVTR WPPSAPVGQR RFSAGPGSTP GQLWGSPGLE GPLASPPARD ERLPSQQPPS
RPPHLPVEER RASAPAGGSP RMLHPATQQS PFMVDLHEQV HQGPVPLSYT VTTVTTQGFP
LPTGQHIPGC SAQQLPACSV MFSGQHYPLC CLPPPLIQAC TMQQLPVPYQ AYPHLISSDH
YILHPPPPAP PPQPTHMAPL GQFVSLQTQH PRMPLQRLDN DVDLRGDQPS LGSFTYSTSA
PGPALSPSVP LHYLPHDPLH QELSFGVPYS HMMPRRLSTQ RYRLQQPLPP PPPPPPPPPY
YPSFLPYFLS MLPMSPTAMG PTISLDLDVD DVEMENYEAL LNLAERLGDA KPRGLTKADI
EQLPSYRFNP DSHQSEQTLC VVCFSDFEAR QLLRVLPCNH EFHTKCVDKW LKANRTCPIC
RADASEVPRE AE
