AB1A_ARATH
ID AB1A_ARATH Reviewed; 1882 AA.
AC Q84M24; Q2V410; Q8S8T6; Q8W010; Q941E2; Q9SDB1;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=ABC transporter A family member 1;
DE Short=ABC transporter ABCA.1;
DE Short=AtABCA1;
DE AltName: Full=ABC one homolog protein 1;
DE Short=AtAOH1;
GN Name=ABCA1; Synonyms=ABC1, AOH1; OrderedLocusNames=At2g41700;
GN ORFNames=T32G6.22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Wassilewskija;
RA Pamard D., Leonhardt N., Forestier C.;
RT "AtABCA1, a plant full size ABC transporter homolog of the mammalian
RT cholesterol efflux regulatory protein ABCA1.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia; TISSUE=Seedling;
RA Yazaki K., Ohishi A., Sato F.;
RT "cDNA cloning of Arabidopsis ABCA1 homologue.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1561-1882.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [7]
RP GENE FAMILY.
RX PubMed=11855639; DOI=10.1007/s004250100661;
RA Martinoia E., Klein M., Geisler M., Bovet L., Forestier C.,
RA Kolukisaoglu H.U., Mueller-Roeber B., Schulz B.;
RT "Multifunctionality of plant ABC transporters -- more than just
RT detoxifiers.";
RL Planta 214:345-355(2002).
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q84M24-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC CPR flippase (TC 3.A.1.211) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC02761.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAK97688.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAM14842.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY032590; AAK39643.3; -; mRNA.
DR EMBL; AB109217; BAC75958.2; -; mRNA.
DR EMBL; AC002339; AAC02761.3; ALT_SEQ; Genomic_DNA.
DR EMBL; AC002510; AAM14842.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC10017.1; -; Genomic_DNA.
DR EMBL; AY052218; AAK97688.1; ALT_INIT; mRNA.
DR EMBL; AY060497; AAL31110.1; -; mRNA.
DR PIR; A84845; A84845.
DR PIR; T00826; T00826.
DR RefSeq; NP_850354.2; NM_180023.4. [Q84M24-1]
DR AlphaFoldDB; Q84M24; -.
DR SMR; Q84M24; -.
DR BioGRID; 4105; 1.
DR IntAct; Q84M24; 1.
DR STRING; 3702.AT2G41700.1; -.
DR TCDB; 3.A.1.211.11; the atp-binding cassette (abc) superfamily.
DR PaxDb; Q84M24; -.
DR PRIDE; Q84M24; -.
DR ProteomicsDB; 244333; -. [Q84M24-1]
DR EnsemblPlants; AT2G41700.1; AT2G41700.1; AT2G41700. [Q84M24-1]
DR GeneID; 818768; -.
DR Gramene; AT2G41700.1; AT2G41700.1; AT2G41700. [Q84M24-1]
DR KEGG; ath:AT2G41700; -.
DR Araport; AT2G41700; -.
DR TAIR; locus:2054366; AT2G41700.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_1_1; -.
DR InParanoid; Q84M24; -.
DR OMA; WKNWIVL; -.
DR OrthoDB; 131191at2759; -.
DR PhylomeDB; Q84M24; -.
DR BioCyc; ARA:AT2G41700-MON; -.
DR PRO; PR:Q84M24; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q84M24; baseline and differential.
DR Genevisible; Q84M24; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 3.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1882
FT /note="ABC transporter A family member 1"
FT /id="PRO_0000379131"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 933..953
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 981..1001
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1178..1198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1225..1245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1250..1270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1290..1310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1366..1386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 549..782
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1453..1691
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 585..592
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1491..1498
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 613
FT /note="G -> E (in Ref. 1; AAK39643)"
FT /evidence="ECO:0000305"
FT CONFLICT 898
FT /note="C -> Y (in Ref. 1; AAK39643)"
FT /evidence="ECO:0000305"
FT CONFLICT 1043
FT /note="A -> T (in Ref. 1; AAK39643)"
FT /evidence="ECO:0000305"
FT CONFLICT 1561
FT /note="V -> L (in Ref. 5; AAK97688)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1882 AA; 209064 MW; 7172814FADDCA6D4 CRC64;
MGSSKRQFKA MLRKNWLLKT RHPFVTSAEI LLPTIVMLLL IAVRTRVDTT IHPAHSNIDK
DTVVEVGKGN SPSFPEVLKL LLAEGDFLAF APDTDETNNM IDILSLKFPE LRLVTKIFKD
DIELETYITS AHYGVCSEVR NCSNPKIKGA VVFHEQGPHL FDYSIRLNHT WAFAGFPNVK
SIMDTNGPYI NDLEMGINTI PTMQYSFSGF LTLQQVVDSF IIFASQQNND LPLSHSNLSS
ALRFELPWTL FSPSVIRMVP FPTREYTDDE FQSIVKSVMG LLYLLGFLFP ISRLISYSVF
EKEQKIREGL YMMGLKDEIF HLSWFITYAL QFALCSGIIT ACTMGSLFKY SDKTLVFTYF
FLFGLSAIML SFMISTFFTR AKTAVAVGTL TFLGAFFPYY TVNDESVSMV LKVVASLLSP
TAFALGSINF ADYERAHVGL RWSNIWRASS GVSFFVCLLM MLLDSILYCA LGLYLDKVLP
RENGVRYPWN FIFSKYFGRK KNNLQNRIPG FETDMFPADI EVNQGEPFDP VFESISLEMR
QQELDGRCIQ VRNLHKVYAS RRGNCCAVNS LQLTLYENQI LSLLGHNGAG KSTTISMLVG
LLPPTSGDAL ILGNSIITNM DEIRKELGVC PQHDILFPEL TVREHLEMFA VLKGVEEGSL
KSTVVDMAEE VGLSDKINTL VRALSGGMKR KLSLGIALIG NSKVIILDEP TSGMDPYSMR
LTWQLIKKIK KGRIILLTTH SMDEAEELGD RIGIMANGSL KCCGSSIFLK HHYGVGYTLT
LVKTSPTVSV AAHIVHRHIP SATCVSEVGN EISFKLPLAS LPCFENMFRE IESCMKNSVD
RSKISEIEDS DYPGIQSYGI SVTTLEEVFL RVAGCNLDIE DKQEDIFVSP DTKSSLVCIG
SNQKSSMQPK LLASCNDGAG VIITSVAKAF RLIVAAVWTL IGFISIQCCG CSIISRSMFW
RHCKALFIKR ARSACRDRKT VAFQFIIPAV FLLFGLLFLQ LKPHPDQKSI TLTTAYFNPL
LSGKGGGGPI PFDLSVPIAK EVAQYIEGGW IQPLRNTSYK FPNPKEALAD AIDAAGPTLG
PTLLSMSEFL MSSFDQSYQS RYGSILMDGQ HPDGSLGYTV LHNGTCQHAG PIYINVMHAA
ILRLATGNKN MTIQTRNHPL PPTKTQRIQR HDLDAFSAAI IVNIAFSFIP ASFAVPIVKE
REVKAKHQQL ISGVSVLSYW LSTYVWDFIS FLFPSTFAII LFYAFGLEQF IGIGRFLPTV
LMLLEYGLAI ASSTYCLTFF FTEHSMAQNV ILMVHFFSGL ILMVISFVMG LIPATASANS
YLKNFFRLSP GFCFSDGLAS LALLRQGMKD KSSHGVFEWN VTGASICYLG LESIFYFLVT
LGLELMPVQK VMSFSIGEWW QNLKAFKQGA GSSSTEPLLK DSTGAISTDM EDDIDVQEER
DRVISGLSDN TMLYLQNLRK VYPGDKHHGP KVAVQSLTFS VQAGECFGFL GTNGAGKTTT
LSMLSGEETP TSGTAFIFGK DIVASPKAIR QHIGYCPQFD ALFEYLTVKE HLELYARIKG
VVDHRIDNVV TEKLVEFDLL KHSHKPSFTL SGGNKRKLSV AIAMIGDPPI VILDEPSTGM
DPVAKRFMWD VISRLSTRSG KTAVILTTHS MNEAQALCTR IGIMVGGRLR CIGSPQHLKT
RYGNHLELEV KPNEVSNVEL ENFCQIIQQW LFNVPTQPRS LLGDLEVCIG VSDSITPDTA
SASEISLSPE MVQRIAKFLG NEQRVSTLVP PLPEEDVRFD DQLSEQLFRD GGIPLPIFAE
WWLTKEKFSA LDSFIQSSFP GATFKSCNGL SIKYQLPFGE GGLSLADAFG HLERNRNRLG
IAEYSISQST LETIFNHFAA NS
