RNFC_VIBC3
ID RNFC_VIBC3 Reviewed; 773 AA.
AC A0A0H3AJC2;
DT 28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT 16-SEP-2015, sequence version 1.
DT 03-AUG-2022, entry version 39.
DE RecName: Full=Ion-translocating oxidoreductase complex subunit C {ECO:0000255|HAMAP-Rule:MF_00461, ECO:0000305};
DE EC=7.-.-.- {ECO:0000255|HAMAP-Rule:MF_00461, ECO:0000305};
DE AltName: Full=Rnf electron transport complex subunit C {ECO:0000255|HAMAP-Rule:MF_00461, ECO:0000305};
GN Name=rnfC {ECO:0000255|HAMAP-Rule:MF_00461};
GN OrderedLocusNames=VC0395_A0536 {ECO:0000312|EMBL:ABQ20645.1};
OS Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS O395).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=345073;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA Heidelberg J.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP SUBCELLULAR LOCATION.
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX PubMed=25831459; DOI=10.1021/acs.biochem.5b00020;
RA Hreha T.N., Mezic K.G., Herce H.D., Duffy E.B., Bourges A., Pryshchep S.,
RA Juarez O., Barquera B.;
RT "Complete topology of the RNF complex from Vibrio cholerae.";
RL Biochemistry 54:2443-2455(2015).
CC -!- FUNCTION: Part of a membrane-bound complex that couples electron
CC transfer with translocation of ions across the membrane.
CC {ECO:0000255|HAMAP-Rule:MF_00461}.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00461};
CC Note=Binds 2 [4Fe-4S] clusters per subunit. {ECO:0000255|HAMAP-
CC Rule:MF_00461};
CC -!- SUBUNIT: The complex is composed of six subunits: RnfA, RnfB, RnfC,
CC RnfD, RnfE and RnfG. {ECO:0000255|HAMAP-Rule:MF_00461}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00461, ECO:0000269|PubMed:25831459}; Peripheral membrane
CC protein {ECO:0000255|HAMAP-Rule:MF_00461, ECO:0000269|PubMed:25831459}.
CC -!- SIMILARITY: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00461}.
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DR EMBL; CP000627; ABQ20645.1; -; Genomic_DNA.
DR RefSeq; WP_000949718.1; NZ_JAACZH010000005.1.
DR AlphaFoldDB; A0A0H3AJC2; -.
DR STRING; 345073.VC395_1030; -.
DR EnsemblBacteria; ABQ20645; ABQ20645; VC0395_A0536.
DR KEGG; vco:VC0395_A0536; -.
DR eggNOG; COG4656; Bacteria.
DR OMA; QQLYWYS; -.
DR Proteomes; UP000000249; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.11540; -; 1.
DR HAMAP; MF_00461; RsxC_RnfC; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR010208; Ion_transpt_RnfC/RsxC.
DR InterPro; IPR011538; Nuo51_FMN-bd.
DR InterPro; IPR037225; Nuo51_FMN-bd_sf.
DR InterPro; IPR026902; RnfC_N.
DR InterPro; IPR019554; Soluble_ligand-bd.
DR PANTHER; PTHR43034; PTHR43034; 1.
DR Pfam; PF01512; Complex1_51K; 1.
DR Pfam; PF12838; Fer4_7; 1.
DR Pfam; PF13375; RnfC_N; 1.
DR Pfam; PF10531; SLBB; 1.
DR SUPFAM; SSF142019; SSF142019; 1.
DR TIGRFAMs; TIGR01945; rnfC; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 2.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 3: Inferred from homology;
KW 4Fe-4S; Cell inner membrane; Cell membrane; Electron transport; Iron;
KW Iron-sulfur; Membrane; Metal-binding; Repeat; Translocase; Transport.
FT CHAIN 1..773
FT /note="Ion-translocating oxidoreductase complex subunit C"
FT /id="PRO_0000443488"
FT DOMAIN 368..398
FT /note="4Fe-4S ferredoxin-type 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00461"
FT DOMAIN 408..437
FT /note="4Fe-4S ferredoxin-type 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00461"
FT REGION 460..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 378
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00461"
FT BINDING 381
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00461"
FT BINDING 384
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00461"
FT BINDING 388
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00461"
FT BINDING 417
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00461"
FT BINDING 420
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00461"
FT BINDING 423
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00461"
FT BINDING 427
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00461"
SQ SEQUENCE 773 AA; 83371 MW; 4BB7CB5D72F4A78F CRC64;
MLSLIEQIKS GKLWDFPGGI HPFENKHQSN RQPIINASIP NELVLPLKQH IGKAGDLLVK
VGDRVLKGQP LTQYTSTFML PIHAPTSGVI SAIEPRTVAH PSGLSELCIV LTPDQQEEWF
ELQPQPDFQQ LTPETLLELI RQAGISGMGG AGFPTAKKLQ SGLSRTEILI INAAECEPYI
TADDVLMRQY AHEIIQGIEI VEHILKPKLT IIGIEDNKPE AVAALQQAAQ DKPMVIRVIP
TKYPSGGEKQ LIKILTNLEV PKGGIPADIG LMVQNVGSLQ AIARAIVHGE PLIRRVVTLT
GDCFRKPRNV WALLGTPVQA LLNEFGYKAD KKLPRLIMGG PMMGFTLPHA QVPITKTANC
ILAPTRNELT SSDNEMACIR CGQCAEACPV SLLPQQLQWH AKAEEFDKCE ELDLKDCIEC
GACAYVCPSE IPLVQYYRQA KAEIRTRSLE AEAAERAKAR FEEKKARMER DKAERENRFK
QAAEDRRKEM QQQGGSDAIA AAIERVKAQK AQLEPTDNSV KPAIAAAIAR AKAKQAEAAQ
SGASEPDNSE MAKLREERKR QARERKAQKG EVTEASTSDG ADDKKSAVAA AIARAKARKA
EQQETESAAQ PAQATPSSDD ADPKKAAVAA AIARAKARKA EQGTESTAQP AQATPSSDEA
DPKKAAVAAA IARAKARKAE QQETESTAQP AQATPSSDDA DPKKAAVAAA IARAKARKAE
QQETKSTAQP EQATPSSDDA DPKKAAVAAA IARAKARKAA QQSSSNLNAE EKD
