RNFT2_MOUSE
ID RNFT2_MOUSE Reviewed; 445 AA.
AC Q3UF64; Q8BXI9;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=RING finger and transmembrane domain-containing protein 2;
DE AltName: Full=Transmembrane protein 118;
GN Name=Rnft2; Synonyms=Tmem118;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata, and Sympathetic ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UF64-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UF64-2; Sequence=VSP_023467;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH57302.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC32896.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE28697.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK046850; BAC32896.1; ALT_INIT; mRNA.
DR EMBL; AK148930; BAE28697.1; ALT_FRAME; mRNA.
DR EMBL; BC057302; AAH57302.1; ALT_INIT; mRNA.
DR CCDS; CCDS19611.2; -. [Q3UF64-2]
DR CCDS; CCDS51632.1; -. [Q3UF64-1]
DR RefSeq; NP_001103372.1; NM_001109902.1. [Q3UF64-1]
DR RefSeq; NP_766586.2; NM_172998.3. [Q3UF64-2]
DR RefSeq; XP_006530407.1; XM_006530344.1. [Q3UF64-2]
DR RefSeq; XP_006530408.1; XM_006530345.2. [Q3UF64-2]
DR RefSeq; XP_006530409.1; XM_006530346.3. [Q3UF64-2]
DR RefSeq; XP_006530410.1; XM_006530347.2. [Q3UF64-2]
DR RefSeq; XP_006530411.1; XM_006530348.2. [Q3UF64-2]
DR RefSeq; XP_006530412.1; XM_006530349.2. [Q3UF64-1]
DR RefSeq; XP_017176390.1; XM_017320901.1. [Q3UF64-1]
DR AlphaFoldDB; Q3UF64; -.
DR STRING; 10090.ENSMUSP00000112903; -.
DR iPTMnet; Q3UF64; -.
DR PhosphoSitePlus; Q3UF64; -.
DR SwissPalm; Q3UF64; -.
DR PaxDb; Q3UF64; -.
DR PRIDE; Q3UF64; -.
DR ProteomicsDB; 300427; -. [Q3UF64-1]
DR ProteomicsDB; 300428; -. [Q3UF64-2]
DR Antibodypedia; 31315; 34 antibodies from 16 providers.
DR DNASU; 269695; -.
DR Ensembl; ENSMUST00000117177; ENSMUSP00000112903; ENSMUSG00000032850. [Q3UF64-2]
DR Ensembl; ENSMUST00000121369; ENSMUSP00000113749; ENSMUSG00000032850. [Q3UF64-1]
DR GeneID; 269695; -.
DR KEGG; mmu:269695; -.
DR UCSC; uc008zgh.2; mouse. [Q3UF64-2]
DR UCSC; uc012ecl.1; mouse. [Q3UF64-1]
DR CTD; 84900; -.
DR MGI; MGI:2442859; Rnft2.
DR VEuPathDB; HostDB:ENSMUSG00000032850; -.
DR eggNOG; KOG4638; Eukaryota.
DR GeneTree; ENSGT00940000158419; -.
DR HOGENOM; CLU_039460_2_0_1; -.
DR InParanoid; Q3UF64; -.
DR OMA; CQADFRE; -.
DR OrthoDB; 1321151at2759; -.
DR PhylomeDB; Q3UF64; -.
DR TreeFam; TF331930; -.
DR BioGRID-ORCS; 269695; 4 hits in 75 CRISPR screens.
DR ChiTaRS; Rnft2; mouse.
DR PRO; PR:Q3UF64; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q3UF64; protein.
DR Bgee; ENSMUSG00000032850; Expressed in embryonic brain and 128 other tissues.
DR ExpressionAtlas; Q3UF64; baseline and differential.
DR Genevisible; Q3UF64; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:1904294; P:positive regulation of ERAD pathway; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR044235; RNFT1/2.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR15860; PTHR15860; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Metal-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..445
FT /note="RING finger and transmembrane domain-containing
FT protein 2"
FT /id="PRO_0000279509"
FT TOPO_DOM 1..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..215
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..256
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 352..445
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT ZN_FING 385..423
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 12..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 27
FT /note="E -> ES (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_023467"
FT CONFLICT 147
FT /note="P -> H (in Ref. 1; BAE28697)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 445 AA; 48856 MW; 687984892639806F CRC64;
MWLLAAHQVL RKMQRRHSSN TDNIPPERSR SQALSPEASV DEGGVFESLK AETASPPALF
SGLAGGLPAS PFPAGLVLGS TAGGGDVFIP MPATRDEAGG RSAEGSTYHH RQAHHHFHHG
AHRGGSLLQH VGGDHRGHSE EGVDEQPGTP APALSELKAV ISWLQKGLPF ILILLAKLCF
QHKLGIAVCI GMASTFAYAN STLREQVSLK EKRSVLVILW ILAFLAGNTM YVLYTFSSQQ
LYSSLIFLKP NLETLDFFDL LWIVGIADFV LKYITIALKC LIVALPKIIL AVKSKGKFYL
VIEELSQLFR SLVPIQLWYK YIMGDDSSNS YFLGGVLIVL YSLCKSFDIC GRVGGLRKAL
KLLCTSQNYG VRATGQQCTE AGAVCAICQA EFRDPMILLC QHVFCEECLC LWLDRERTCP
LCRSVAVDTL RCWKDGATSA HLQVY
