RNGB_DICDI
ID RNGB_DICDI Reviewed; 943 AA.
AC Q7M3S9; Q55EJ8;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=RING finger protein B;
DE Short=Protein rngB;
GN Name=rngB; ORFNames=DDB_G0268860;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=8647262; DOI=10.1016/0014-5793(96)00411-5;
RA Kawata T., Steel J.B., Williams J.G.;
RT "RNGB: a Dictyostelium RING finger protein that is specifically located in
RT maturing spore cells.";
RL FEBS Lett. 386:103-109(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8647262}.
CC -!- DEVELOPMENTAL STAGE: Present in low amounts in growing cells and
CC increases steadily during development. Specifically localized in
CC maturing spore. {ECO:0000269|PubMed:8647262}.
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DR EMBL; AAFI02000004; EAL73019.1; -; Genomic_DNA.
DR PIR; S68824; S68824.
DR RefSeq; XP_647022.1; XM_641930.1.
DR AlphaFoldDB; Q7M3S9; -.
DR SMR; Q7M3S9; -.
DR STRING; 44689.DDB0220505; -.
DR PaxDb; Q7M3S9; -.
DR EnsemblProtists; EAL73019; EAL73019; DDB_G0268860.
DR GeneID; 8616716; -.
DR KEGG; ddi:DDB_G0268860; -.
DR dictyBase; DDB_G0268860; rngB.
DR eggNOG; KOG0379; Eukaryota.
DR eggNOG; KOG1100; Eukaryota.
DR HOGENOM; CLU_311564_0_0_1; -.
DR InParanoid; Q7M3S9; -.
DR OMA; WNRIKLQ; -.
DR PRO; PR:Q7M3S9; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; TAS:dictyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.80; -; 2.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01344; Kelch_1; 1.
DR SMART; SM00612; Kelch; 3.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF117281; SSF117281; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Kelch repeat; Metal-binding; Reference proteome;
KW Repeat; Zinc; Zinc-finger.
FT CHAIN 1..943
FT /note="RING finger protein B"
FT /id="PRO_0000056114"
FT REPEAT 30..78
FT /note="Kelch 1"
FT REPEAT 139..190
FT /note="Kelch 2"
FT REPEAT 192..241
FT /note="Kelch 3"
FT ZN_FING 897..932
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 354..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 593..653
FT /evidence="ECO:0000255"
FT COILED 743..845
FT /evidence="ECO:0000255"
FT COILED 872..896
FT /evidence="ECO:0000255"
FT CONFLICT 253
FT /note="D -> S (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 850
FT /note="L -> M (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 943 AA; 106113 MW; CEFB628449726559 CRC64;
MKIDCKRVSL IGSPEPRWGH TGTTLPNGSG FIVFGGNSNR AFNDIQYYNI FNNSWSKIEA
VGNAPSERYG HSAVLYQSQS RPYSDSYQII FFGGRATSKP FSDINILYVN SNRSFIWKQV
TTKSIEGRAG HTAVVYRQNL VVFGGHNNHK SKYYNSVLLF SLESNEWRQQ VCGGVIPSAR
ATHSTFQVNN NKMFIFGGYD GKKYYNDIYY LDLETWIWKK VEAKGTPPKP RSGHSATMIQ
NNKLMIFGGC GSDSNFLNDI HILHIEGANE YRWEQPSYLG LEIPQARFRH TTNFIGGRVY
IYAGTGSGNL MGDLHTLEFL DDNNTPLIPI TISIPITNSN SIVGSPNTSI SCGVSNSGAS
SSSGGGISGH PSILSSSSSS SYLSTSPLST SSLASSYQSS QSLQFNQNQN QNNNNNNNNN
NNNNIQTTTT TTTNNNNNNN NNNNNNNNNN NVESNQQQQQ IQHQTSPMSV LSRSNSNISL
NSLNSSSSSI LSTPSTLSTT TTTTTTSHAS HTSHTSNRSN GSRGGIPSIP PFNGRSSNHN
NNNNSNSNNY NNHQQTKTNS AEELILEELK SLNIYDQAAC NKDFQTNLKR VEELFNQKIK
HEQKYRQSLE EKLGKANHQV SLLTNQIQSI IQKDELTSLK KEYSELKKKH SLLYSEDIDD
LPTETCLKLE EIHVKSLEKL RVKKLPSSNQ LSTLQQQIPQ QPTTIICNNS QIIQQQPLPP
LQQQQQQQQQ QQQQQQQQQQ PLEIQEQLTM LQLQLSQLSQ QQQNQIDKQQ KQEKLQQEQQ
QQQLKNINRL SISSNSSTLS SKDSFYFESK IQELSNQLKE KQQAITDRDN KIKDFENQLN
KYKLIGLDSL DHYQLLELES SFHNGLKQIG SIKDQRYLNR LVSLEKEKDQ LKDQNSCVIC
ASNPPNIVLL PCRHSSLCSD CCSKLTKCPI CRSHIENKIS IYQ
