ID   RNH2B_RAT               Reviewed;         307 AA.
AC   Q5XI96;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Ribonuclease H2 subunit B;
DE            Short=RNase H2 subunit B;
DE   AltName: Full=Ribonuclease HI subunit B;
GN   Name=Rnaseh2b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Non catalytic subunit of RNase H2, an endonuclease that
CC       specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA
CC       replication, possibly by mediating the removal of lagging-strand
CC       Okazaki fragment RNA primers during DNA replication. Mediates the
CC       excision of single ribonucleotides from DNA:RNA duplexes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The RNase H2 complex is a heterotrimer composed of the
CC       catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and
CC       RNASEH2C. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNase H2 subunit B family. {ECO:0000305}.
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DR   EMBL; BC083791; AAH83791.1; -; mRNA.
DR   RefSeq; NP_001007008.1; NM_001007007.1.
DR   AlphaFoldDB; Q5XI96; -.
DR   SMR; Q5XI96; -.
DR   STRING; 10116.ENSRNOP00000012231; -.
DR   PaxDb; Q5XI96; -.
DR   GeneID; 361056; -.
DR   KEGG; rno:361056; -.
DR   UCSC; RGD:1359710; rat.
DR   CTD; 79621; -.
DR   RGD; 1359710; Rnaseh2b.
DR   VEuPathDB; HostDB:ENSRNOG00000009192; -.
DR   eggNOG; KOG4705; Eukaryota.
DR   HOGENOM; CLU_059802_0_0_1; -.
DR   InParanoid; Q5XI96; -.
DR   OMA; MACDIVG; -.
DR   OrthoDB; 1092212at2759; -.
DR   PhylomeDB; Q5XI96; -.
DR   TreeFam; TF105250; -.
DR   PRO; PR:Q5XI96; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000009192; Expressed in thymus and 19 other tissues.
DR   Genevisible; Q5XI96; RN.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0032299; C:ribonuclease H2 complex; ISS:UniProtKB.
DR   GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR   GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
DR   GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISO:RGD.
DR   GO; GO:2000001; P:regulation of DNA damage checkpoint; ISO:RGD.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; ISO:RGD.
DR   GO; GO:0009259; P:ribonucleotide metabolic process; ISO:RGD.
DR   GO; GO:0006401; P:RNA catabolic process; ISS:UniProtKB.
DR   CDD; cd09270; RNase_H2-B; 1.
DR   InterPro; IPR040456; RNase_H2_suB.
DR   InterPro; IPR019024; RNase_H2_suB_wHTH.
DR   InterPro; IPR041195; Rnh202_N.
DR   PANTHER; PTHR13383; PTHR13383; 1.
DR   Pfam; PF09468; RNase_H2-Ydr279; 1.
DR   Pfam; PF17745; Ydr279_N; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nucleus; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TBB1"
FT   CHAIN           2..307
FT                   /note="Ribonuclease H2 subunit B"
FT                   /id="PRO_0000248380"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TBB1"
FT   MOD_RES         291
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TBB1"
FT   MOD_RES         292
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TBB1"
SQ   SEQUENCE   307 AA;  34573 MW;  B6FDD88D8939100B CRC64;
     MAGGRDRGDL AARQLVFLLP EYLKDASRKS KSGLLFVKLV NPHSGEGATY LIDACLQKLF
     EIKVFKEKHH SWFINQSVQS GGLLHFATPM DPLFLLLHYL IKAGKEGKYQ PLDQVVVDDK
     FPDCTLLLRF PELEKSLRHV TEEKEVNSKK YYKYSTEKTL KWLEKKVNQT VAALKANHVN
     VGARVQSSAY FSGVQVSRDK EEDYVRYAHG LISDYIPKEL SDDLSKLLKL PEPPASLPNP
     PAKKLKLADE PVEAKEDYTK FNTKDLKNGK KNSKMTAAQK ALAKVDKSGM KSIDAFFGAK
     NKKTGKI