ID   RNH2B_XENLA             Reviewed;         306 AA.
AC   Q5HZP1;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Ribonuclease H2 subunit B;
DE            Short=RNase H2 subunit B;
DE   AltName: Full=Ribonuclease HI subunit B;
GN   Name=rnaseh2b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non catalytic subunit of RNase H2, an endonuclease that
CC       specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA
CC       replication, possibly by mediating the removal of lagging-strand
CC       Okazaki fragment RNA primers during DNA replication. Mediates the
CC       excision of single ribonucleotides from DNA:RNA duplexes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The RNase H2 complex is a heterotrimer composed of the
CC       catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and
CC       RNASEH2C. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNase H2 subunit B family. {ECO:0000305}.
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DR   EMBL; BC088940; AAH88940.1; -; mRNA.
DR   RefSeq; NP_001088963.1; NM_001095494.1.
DR   AlphaFoldDB; Q5HZP1; -.
DR   SMR; Q5HZP1; -.
DR   DNASU; 496343; -.
DR   GeneID; 496343; -.
DR   KEGG; xla:496343; -.
DR   CTD; 496343; -.
DR   Xenbase; XB-GENE-1004449; rnaseh2b.L.
DR   OMA; MACDIVG; -.
DR   OrthoDB; 1092212at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 496343; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032299; C:ribonuclease H2 complex; ISS:UniProtKB.
DR   GO; GO:0006401; P:RNA catabolic process; ISS:UniProtKB.
DR   CDD; cd09270; RNase_H2-B; 1.
DR   InterPro; IPR040456; RNase_H2_suB.
DR   InterPro; IPR019024; RNase_H2_suB_wHTH.
DR   InterPro; IPR041195; Rnh202_N.
DR   PANTHER; PTHR13383; PTHR13383; 1.
DR   Pfam; PF09468; RNase_H2-Ydr279; 1.
DR   Pfam; PF17745; Ydr279_N; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..306
FT                   /note="Ribonuclease H2 subunit B"
FT                   /id="PRO_0000248381"
FT   REGION          232..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..269
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   306 AA;  34243 MW;  A1839D2B7A41D50B CRC64;
     MVSRRKAPRS GQSEQWVLLA PESLSGDAKN LSDETVFVKL RAPFADKGAM FLFINSGQQI
     CEVKAFHEEY RSWFIGQTVQ QDGRLLIATP IDPLFLVLPY LIKADKEQGK FQPVEQIVVD
     EEFPSCGMLL QCTPVAKSLH HVTEEKEIGS KKFHKYSKEK ALVWLKKKVD QTVKVLKSSK
     VCVGGGVQSA TFIRSTQGSD VKEEDYTRYA HGLISEYLTE DLREDLSKYL GLPDLSSPTP
     EPPVKKRRVS DAPVEADEDY TKYNSDNKSR KSNSKMTAAQ KSLAKVDKSG MKNISAFFSP
     KAKAAK