ID   RNH2C_BOVIN             Reviewed;         165 AA.
AC   Q2M2U4;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Ribonuclease H2 subunit C;
DE            Short=RNase H2 subunit C;
DE   AltName: Full=Ribonuclease HI subunit C;
GN   Name=RNASEH2C;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non catalytic subunit of RNase H2, an endonuclease that
CC       specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA
CC       replication, possibly by mediating the removal of lagging-strand
CC       Okazaki fragment RNA primers during DNA replication. Mediates the
CC       excision of single ribonucleotides from DNA:RNA duplexes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The RNase H2 complex is a heterotrimer composed of the
CC       catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and
CC       RNASEH2C. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNase H2 subunit C family. {ECO:0000305}.
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DR   EMBL; BC111611; AAI11612.1; -; mRNA.
DR   RefSeq; NP_001039386.1; NM_001045921.1.
DR   AlphaFoldDB; Q2M2U4; -.
DR   SMR; Q2M2U4; -.
DR   STRING; 9913.ENSBTAP00000007327; -.
DR   PaxDb; Q2M2U4; -.
DR   PRIDE; Q2M2U4; -.
DR   Ensembl; ENSBTAT00000007327; ENSBTAP00000007327; ENSBTAG00000005577.
DR   GeneID; 505618; -.
DR   KEGG; bta:505618; -.
DR   CTD; 84153; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005577; -.
DR   VGNC; VGNC:34001; RNASEH2C.
DR   eggNOG; ENOG502SBKV; Eukaryota.
DR   GeneTree; ENSGT00390000001568; -.
DR   HOGENOM; CLU_097632_3_0_1; -.
DR   InParanoid; Q2M2U4; -.
DR   OMA; YFNNYTR; -.
DR   OrthoDB; 1542008at2759; -.
DR   TreeFam; TF324370; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000005577; Expressed in laryngeal cartilage and 107 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032299; C:ribonuclease H2 complex; ISS:UniProtKB.
DR   GO; GO:0006401; P:RNA catabolic process; ISS:UniProtKB.
DR   CDD; cd09271; RNase_H2-C; 1.
DR   InterPro; IPR013924; RNase_H2_suC.
DR   Pfam; PF08615; RNase_H2_suC; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nucleus; Reference proteome.
FT   CHAIN           1..165
FT                   /note="Ribonuclease H2 subunit C"
FT                   /id="PRO_0000248384"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDP1"
SQ   SEQUENCE   165 AA;  18349 MW;  0F8E0AA3B7284141 CRC64;
     MENSYEETID KRRVHLRPDT LRDPAPASLH LLPCEVPVNR PTPVGRFFTP AIRMGRDGLE
     ASFRGRSLRG EEVVVPPGFV GYVVTEEKAE VLMGKQDDHE RQEQELLEPP EALERDCDRF
     MGATASFSSF TVWGLESIPG PDAKLRGALS WPSLAAAIHA QVPED