ID   AB1IP_CHICK             Reviewed;         485 AA.
AC   Q5ZL23;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Amyloid beta A4 precursor protein-binding family B member 1-interacting protein;
DE   AltName: Full=APBB1-interacting protein 1;
GN   Name=APBB1IP; ORFNames=RCJMB04_8c12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Appears to function in the signal transduction from Ras
CC       activation to actin cytoskeletal remodeling.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm,
CC       cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MRL family. {ECO:0000305}.
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DR   EMBL; AJ719911; CAG31570.1; -; mRNA.
DR   AlphaFoldDB; Q5ZL23; -.
DR   SMR; Q5ZL23; -.
DR   STRING; 9031.ENSGALP00000012240; -.
DR   PaxDb; Q5ZL23; -.
DR   VEuPathDB; HostDB:geneid_420492; -.
DR   eggNOG; KOG3751; Eukaryota.
DR   InParanoid; Q5ZL23; -.
DR   PhylomeDB; Q5ZL23; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01259; PH_APBB1IP; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR039664; GRB/APBB1IP.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR039665; PH_APBB1IP.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR11243; PTHR11243; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50200; RA; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Cytoskeleton; Membrane; Reference proteome.
FT   CHAIN           1..485
FT                   /note="Amyloid beta A4 precursor protein-binding family B
FT                   member 1-interacting protein"
FT                   /id="PRO_0000181349"
FT   DOMAIN          175..262
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT   DOMAIN          305..414
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          84..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..119
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..149
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   485 AA;  54748 MW;  C4EE1C5B1283EE34 CRC64;
     MEQTCDDIDE MFSNLLGEMD MLTQSLGVET VQTPSPKVTN EEFSFTVGFK DLNESLNALE
     DKDLDALMAD LVADINEVEQ RTLQAQKTSG NQQSVVTQPS TGTNNDFCSK LSPCATITGQ
     FKNDLPPPPP APDLDLPPPP PPPPPEPLSQ EEQEARAKAD KIKLALEKLK EAKIKKLVVK
     VHMYDNSTKS LMVDERQVTR DVLDNLFEKT HCDCSVDWCL YEVYPELQIE RFFEDHENVV
     EVLSDWTRDS ENKVLFLEKK EKYALFKNPQ NFYLANKGKN ESKEMNDKSK EALLEESFCG
     ASVIVPELEG ALYLKEDGKK SWKRRYFLLR ASGIYYVPKG KTKTSRDLMC FIQFENMNVY
     YGSQHKVKYK APTDHCFVLK HPQIQKESQY IKYLCCDDRA TLHQWVTGIR IAKYGKTLYD
     NYKCAVKKAG LSSQWANQGT LEPAAPTGSL SAGAVQANGQ IPRVVLPSSA EVAETQKKVD
     PAIRA