ID   AB1IP_XENLA             Reviewed;         653 AA.
AC   Q6DCV1;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 2.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Amyloid beta A4 precursor protein-binding family B member 1-interacting protein;
DE   AltName: Full=APBB1-interacting protein 1;
GN   Name=apbb1ip;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Appears to function in the signal transduction from Ras
CC       activation to actin cytoskeletal remodeling.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm,
CC       cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MRL family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH77889.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC077889; AAH77889.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001087106.2; NM_001093637.1.
DR   AlphaFoldDB; Q6DCV1; -.
DR   SMR; Q6DCV1; -.
DR   GeneID; 446995; -.
DR   KEGG; xla:446995; -.
DR   CTD; 446995; -.
DR   Xenbase; XB-GENE-950414; apbb1ip.S.
DR   OrthoDB; 786893at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 446995; Expressed in spleen and 16 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01259; PH_APBB1IP; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR039664; GRB/APBB1IP.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR039665; PH_APBB1IP.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR11243; PTHR11243; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50200; RA; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Cytoskeleton; Membrane; Reference proteome.
FT   CHAIN           1..653
FT                   /note="Amyloid beta A4 precursor protein-binding family B
FT                   member 1-interacting protein"
FT                   /id="PRO_0000181351"
FT   DOMAIN          165..253
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT   DOMAIN          295..404
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          82..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          462..653
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..136
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        463..478
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..502
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        525..607
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   653 AA;  72681 MW;  CB6633CE6D496DDE CRC64;
     MDEIDEMFSN LLGEMDLLTQ SLEIETLPPP TRSASTTEIN FSVGFKDLNE SLNALEDNDL
     DALMAELVAD ITDAEQNVAT YNNKSTAPFP PADASNSYHF HPPPMPSIIT EDLSLLPPPP
     EFDPHYPPPP PDPLTEPKTQ EELESKAKAN KINLALSKMK EAKVKKRIVK VHMIDSSTKT
     LMVEEHQTVR DVLDNLFEKT HCDCSIEWCL FEVTPELQIE RFFEDHENIV EILANWTRDS
     VNTIHFLEKN EKYAVFKKPQ NFYMATKGSA DLKDMNEKNK VSLLEQSFCG ASVTVPELEA
     ALYLKEDGKK SWKKRYFLLR ASGIYYVPKG KTKTSRDLAC FVQFDNVNVY YGTQYRMKYK
     APTDHCFVLK HPQIQKESQY IKYLCCEDPW LLHQWVTGIR IAKYGKILYD NYKTAVQRGG
     LASHWSTLGS SSVSTAAGSS QGNGQICQNV TTISSSFSDA WKHGEANKQE KKSSEVNKPE
     TKSATPTVTK RPPPTPRRAS SISRVTDHPA FPPKPKAINT DIMSGPPQFP PPEPLQPADD
     FLPPPPPDFF DAPPDFLPPS PPSFMSNAEN PPPPPVTQLQ MSNAPAPPPP PPPPAPAANV
     PPLPVKKHPP KPPKRQSIVG PMPGTNAHGG AGGQPDFMSD LMKALQKKRE PPT