ID   RNKA_XENLA              Reviewed;         101 AA.
AC   A2VDC7;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Ribonuclease kappa-A;
DE            Short=RNase K-A;
DE            Short=RNase kappa-A;
DE            EC=3.1.-.-;
GN   Name=rnasek-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endoribonuclease which preferentially cleaves ApU and ApG
CC       phosphodiester bonds. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RNase K family. {ECO:0000305}.
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DR   EMBL; BC129756; AAI29757.1; -; mRNA.
DR   RefSeq; NP_001091376.1; NM_001097907.1.
DR   AlphaFoldDB; A2VDC7; -.
DR   SMR; A2VDC7; -.
DR   DNASU; 100037220; -.
DR   GeneID; 100037220; -.
DR   KEGG; xla:100037220; -.
DR   CTD; 100037220; -.
DR   Xenbase; XB-GENE-6254981; rnasek.S.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 100037220; Expressed in internal ear and 20 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004521; F:endoribonuclease activity; ISS:UniProtKB.
DR   InterPro; IPR026770; RNase_K.
DR   PANTHER; PTHR31733; PTHR31733; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Membrane; Nuclease; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..101
FT                   /note="Ribonuclease kappa-A"
FT                   /id="PRO_0000344225"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   101 AA;  11400 MW;  9DD93A7399951DC3 CRC64;
     MVSLLCCGPK LAACGIVISV WGVIMLILLG VFFNVHSAVL IEDVPFTEED IFEDPNPPAK
     MYRLYEQVSY NCFIAAAIYI VLGGFSFCQV RLNKRKEYMV R