ID   RNL1_PIG                Reviewed;          34 AA.
AC   P15466;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Ribonuclease PL1;
DE            EC=4.6.1.18;
DE   Flags: Fragment;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RX   PubMed=2611266; DOI=10.1021/bi00451a040;
RA   Hofsteenge J., Matthies R., Stone S.R.;
RT   "Primary structure of a ribonuclease from porcine liver, a new member of
RT   the ribonuclease superfamily.";
RL   Biochemistry 28:9806-9813(1989).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-
CC         phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].; EC=4.6.1.18;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'-
CC         phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].; EC=4.6.1.18;
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000305}.
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DR   PIR; A33627; A33627.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004522; F:ribonuclease A activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.10.130.10; -; 1.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Endonuclease; Glycoprotein; Hydrolase; Lyase;
KW   Lysosome; Nuclease; Reference proteome.
FT   CHAIN           1..>34
FT                   /note="Ribonuclease PL1"
FT                   /id="PRO_0000057161"
FT   ACT_SITE        15
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine; partial"
FT   NON_TER         34
SQ   SEQUENCE   34 AA;  3933 MW;  F2176DE8A6F517B3 CRC64;
     IPKNLTRAQW FTIQHIQPSP LQXNKAMNGV NXYT